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eIF4A1 (human)

Overview eIF4A1 ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with PAIP1, EIF4E and UPF2. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. May interact with NOM1. Interacts with PDCD4; this interferes with the interaction between EIF4A and EIF4G. Interacts with RBM4. Interacts with human cytomegalovirus/HHV-5 protein UL69. Helicase activity and function in translation are inhibited by interaction with PDCD4. Belongs to the DEAD box helicase family. eIF4A subfamily. Note: This description may include information from UniProtKB. Protein type: Translation initiation; RNA binding protein; Helicase; Translation; EC 3.6.1.-; EC 3.6.4.13 Cellular Component: eukaryotic translation initiation factor 4F complex; cytosol Molecular Function: mRNA binding; protein binding; translation factor activity, nucleic acid binding; translation initiation factor activity; ATP-dependent helicase activity; helicase activity; RNA cap binding; ATP binding Biological Process: poly(A) tail shortening; organ regeneration; cellular protein metabolic process; translation; RNA metabolic process; cytokine and chemokine mediated signaling pathway; virus-host interaction; translational initiation; gene expression; mRNA catabolic process, deadenylation-dependent decay; mRNA metabolic process Reference #:  P60842 (UniProtKB) Alt. Names/Synonyms: ATP-dependent RNA helicase eIF4A-1; DDX2A; EIF-4A; eIF-4A-I; EIF4A; eIF4A-I; EIF4A1; Eukaryotic initiation factor 4A-I; eukaryotic initiation factor 4AI; eukaryotic translation initiation factor 4A, isoform 1; eukaryotic translation initiation factor 4A1; IF4A1 Gene Symbols: EIF4A1 Molecular weight: 46,154 Da Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states CST Pathways:  Translation: eIF4E and p70S6K Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below eIF4A1 2G9N - A/B=20-236 (human) 2ZU6 - F/A/D/C=20-406 (human) 3EIQ - A/D=1-406 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2G9N 2ZU6 3EIQ  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S4-p	____MSAsQDSRSRD
0	83		Y48-p	ESLLRGIyAyGFEkP
0	7		Y50-p	LLRGIyAyGFEkPSA
0	116		K54-u	IyAyGFEkPSAIQQR
0	2		K68-u	RAILPCIkGyDVIAQ
0	12		Y70-p	ILPCIkGyDVIAQAQ
0	2		S78-p	DVIAQAQsGtGKTAT
0	2		T80-p	IAQAQsGtGKTATFA
0	1		T83	AQsGtGKTATFAISI
0	1		T101	IELDLKATQALVLAP
0	1		K118-a	ELAQQIQkVVMALGD
0	9		K118-u	ELAQQIQkVVMALGD
0	1		Y126	VVMALGDYMGASCHA
0	86		K146-u	NVRAEVQkLQMEAPH
0	2		T158-p	APHIIVGtPGRVFDM
0	2		K174-a	NRRYLSPkYIkMFVL
0	39		K174-u	NRRYLSPkYIkMFVL
0	15		K177-u	YLSPkYIkMFVLDEA
0	1		K193-a	EMLSRGFkDQIyDIF
0	46		K193-u	EMLSRGFkDQIyDIF
0	41		Y197-p	RGFkDQIyDIFQkLN
0	2		K202-u	QIyDIFQkLNSNTQV
0	83		K225-u	SDVLEVTkkFMRDPI
0	29		K226-u	DVLEVTkkFMRDPIR
0	5		K237-u	DPIRILVkkEELTLE
0	4		K238-a	PIRILVkkEELTLEG
0	13		K238-u	PIRILVkkEELTLEG
0	28		K284-u	IFINTRRkVDWLTEk
0	24		K291-u	kVDWLTEkMHARDFT
0	4		K309-a	MHGDMDQkERDVIMR
0	93		K309-u	MHGDMDQkERDVIMR
0	86		K369-u	RGGRFGRkGVAINMV
0	61		K381-u	NMVTEEDkRTLRDIE

	mouse
S4	____MSASQDSRSRD
Y48-p	ESLLRGIyAyGFEkP
Y50-p	LLRGIyAyGFEkPSA
K54-u	IyAyGFEkPSAIQQR
K68-u	RAILPCIkGyDVIAQ
Y70-p	ILPCIkGyDVIAQAQ
S78	DVIAQAQSGTGKTAT
T80	IAQAQSGTGKTATFA
T83	AQSGTGKTATFAISI
T101-p	IELDLKAtQALVLAP
K118	ELAQQIQKVVMALGD
K118-u	ELAQQIQkVVMALGD
Y126-p	VVMALGDyMGASCHA
K146-u	NVRAEVQkLQMEAPH
T158	APHIIVGTPGRVFDM
K174	NRRYLSPKYIKMFVL
K174-u	NRRYLSPkYIKMFVL
K177	YLSPkYIKMFVLDEA
K193	EMLSRGFKDQIyDIF
K193-u	EMLSRGFkDQIyDIF
Y197-p	RGFkDQIyDIFQkLN
K202-u	QIyDIFQkLNSNTQV
K225-u	SDVLEVTkkFMRDPI
K226-u	DVLEVTkkFMRDPIR
K237	DPIRILVKkEELTLE
K238	PIRILVKKEELTLEG
K238-u	PIRILVKkEELTLEG
K284-u	IFINTRRkVDWLTEk
K291-u	kVDWLTEkMHARDFT
K309	MHGDMDQKERDVIMR
K309-u	MHGDMDQkERDVIMR
K369-u	RGGRFGRkGVAINMV
K381-u	NMVTEEDkRTLRDIE

	rat
S4	____MSASQDSRSRD
Y48-p	ESLLRGIyAYGFEkP
Y50	LLRGIyAYGFEkPSA
K54-u	IyAYGFEkPSAIQQR
K68	RAILPCIKGYDVIAQ
Y70	ILPCIKGYDVIAQAQ
S78-p	DVIAQAQsGtGKtAT
T80-p	IAQAQsGtGKtATFA
T83-p	AQsGtGKtATFAISI
T101	IELDLKATQALVLAP
K118	ELAQQIQKVVMALGD
K118	ELAQQIQKVVMALGD
Y126	VVMALGDYMGASCHA
K146-u	NVRAEVQkLQMEAPH
T158	APHIIVGTPGRVFDM
K174	NRRYLSPKYIKMFVL
K174	NRRYLSPKYIKMFVL
K177	YLSPKYIKMFVLDEA
K193	EMLSRGFKDQIyDIF
K193	EMLSRGFKDQIyDIF
Y197-p	RGFKDQIyDIFQKLN
K202	QIyDIFQKLNSNTQV
K225	SDVLEVTKKFMRDPI
K226	DVLEVTKKFMRDPIR
K237	DPIRILVKKEELTLE
K238	PIRILVKKEELTLEG
K238	PIRILVKKEELTLEG
K284	IFINTRRKVDWLTEK
K291	KVDWLTEKMHARDFT
K309	MHGDMDQKERDVIMR
K309	MHGDMDQKERDVIMR
K369	RGGRFGRKGVAINMV
K381	NMVTEEDKRTLRDIE

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