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Protein Page:
eIF3-theta (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
eIF3-theta Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Interacts with EIF4G1. Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3L and EIF3K. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with KRT7 and PIWIL2. Belongs to the eIF-3 subunit A family. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Cellular Component: eukaryotic translation initiation factor 3 complex; cytoplasm; nucleolus; cytosol; nucleus
Molecular Function: protein binding; translation initiation factor activity; structural molecule activity
Biological Process: cellular protein metabolic process; translation; translational initiation; formation of translation initiation complex; gene expression; formation of translation preinitiation complex; regulation of translational initiation
Reference #:  Q14152 (UniProtKB)
Alt. Names/Synonyms: centrosomin homolog; cytoplasmic protein p167; eIF-3-theta; EIF3; eIF3 p167; eIF3 p180; eIF3 p185; EIF3, p180 subunit; eIF3-p170; eIF3-theta; EIF3A; EIF3S10; Eukaryotic translation initiation factor 3 subunit 10; Eukaryotic translation initiation factor 3 subunit A; eukaryotic translation initiation factor 3, subunit 10 (theta, 150/170kD); eukaryotic translation initiation factor 3, subunit 10 (theta, 170kD); eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa; eukaryotic translation initiation factor 3, subunit 10, 170kD; eukaryotic translation initiation factor 3, subunit A; KIAA0139; P167; p180; p185; TIF32
Gene Symbols: EIF3A
Molecular weight: 166,569 Da
Basal Isoelectric point: 6.38  Predict pI for various phosphorylation states
CST Pathways:  Translational Control
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

eIF3-theta

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 19 Y4-p ____MPAyFQRPENA
0 1 K13 QRPENALKRANEFLE
0 1 K13-ub QRPENALkRANEFLE
0 2 K23-ub NEFLEVGkkQPALDV
0 3 K24-ub EFLEVGkkQPALDVL
0 21 Y32-p QPALDVLyDVMKSKK
0 2 K45-ub KKHRTWQkIHEPIML
0 2 K68-ac LRKSHLAkEGLyQYk
0 1 K68 LRKSHLAKEGLyQYk
0 11 Y72-p HLAkEGLyQYkNICQ
0 9 K75-ub kEGLyQYkNICQQVN
0 1 K183 DIAQQAFKFCLQYTR
0 1 S261-p EDIHGLFsLSKKPPK
0 1 Y275 KPQLMANYYNKVSTV
0 1 Y276 PQLMANYYNKVSTVF
0 2 K285-ub KVSTVFWkSGNALFH
0 1 K308 HLSREMRKNLtQDEM
0 1 T311-p REMRKNLtQDEMQRM
0 1 T326-p STRVLLAtLsIPItP
0 1 S328-p RVLLAtLsIPItPER
0 3 T332-p AtLsIPItPERTDIA
0 1 T336 IPItPERTDIARLLD
0 25 K351-ub MDGIIVEkQRRLATL
0 14 Y382-p VRFNVLQyVVPEVKD
0 19 K402-ub EVEFNPLkLCERVTk
0 2 K409-ub kLCERVTkVLNWVRE
0 84 K420-ub WVREQPEkEPELQQY
0 2 S492-p DHTSRTLsFGSDLNY
0 1 S528-p NQLTAMSsVLAKALE
0 1 K532 AMSsVLAKALEVIKP
0 1 K559 LAVTAYLKNSRKEHQ
0 264 T574-p RILARRQtIEERKER
0 1 K579 RQtIEERKERLEsLN
0 32 S584-p ERKERLEsLNIQREK
0 1 K591 sLNIQREKEELEQRE
0 1 K603 QREAELQKVRKAEEE
0 10 K632-ub LQEHEQIkkktVRER
0 1 K632-m1 LQEHEQIkkktVRER
0 1 K633-ub QEHEQIkkktVRERL
0 1 K633-m1 QEHEQIkkktVRERL
0 1 K634-m1 EHEQIkkktVRERLE
0 3 T635-p HEQIkkktVRERLEQ
0 1 T646-p RLEQIKKtELGAkAF
0 4 K651-ub KKtELGAkAFkDIDI
0 7 K654-ub ELGAkAFkDIDIEDL
0 11 K672-ub DPDFIMAkQVEQLEK
0 1 K682-ub EQLEKEKkELQERLK
0 1 K693-ac ERLKNQEkkIDYFER
0 1 K694-ac RLKNQEkkIDYFERA
0 2 K694-ub RLKNQEkkIDYFERA
0 6 K711-ub LEEIPLIkSAYEEQR
0 1 K720-ub AYEEQRIkDMDLWEQ
0 1 K775 RQSVYEEKLkQFEER
0 74 K775-ub RQSVYEEkLkQFEER
0 4 K777-ub SVYEEkLkQFEERLA
0 5 K824-ub RAEEQMLkEREERER
0 8 Y844-p REEELREyQERVKKL
0 6 S881-p EERRLGDssLsRKDs
0 11 S882-p ERRLGDssLsRKDsR
0 3 S884-p RLGDssLsRKDsRWG
0 6 S888-p ssLsRKDsRWGDRDs
0 2 S895-p sRWGDRDsEGtWRKG
0 9 T898-p GDRDsEGtWRKGPEA
0 1 S949-p DDEDREPsLRPDDDR
0 2 A982 DRFSRRGADDDRPSW
0 2 S1028-p GLDEDRGsWRTADED
0 1 S1059 GADDERSSWRNADDD
0 2 K1174-ac GPWRPLVkPGGWREK
0 20 S1188-p KEKAREEsWGPPRES
0 2 S1198-p PPRESRPsEEREWDR
0 1 S1256-p RRGPAEEssSWRDsS
0 1 S1257-p RGPAEEssSWRDsSR
0 1 S1262-p EssSWRDsSRRDDRD
0 1 S1309-p SEREEVSsWRRADDR
0 1 V1321 DDRKDDRVEERDPPR
0 9 S1336-p RVPPPALsRDRERDR
0 1 K1351-ac DREREGEkEKAsWRA
0 1 S1355-p EGEkEKAsWRAEKDR
0 39 S1364-p RAEKDREsLRRtKNE
0 1 T1368-p DREsLRRtKNEtDED
0 8 T1372-p LRRtKNEtDEDGWtt
0 1 T1378-p EtDEDGWttVRR___
0 7 T1379-p tDEDGWttVRR____
  mouse

 
Y4 ____MPAYFQRPENA
K13-ac QRPENALkRANEFLE
K13 QRPENALKRANEFLE
K23-ub NEFLEVGkkQPALDV
K24-ub EFLEVGkkQPALDVL
Y32-p QPALDVLyDVMKSKK
K45-ub KKHRTWQkIHEPIML
K68-ac LRKSHLAkEGLYQYk
K68-ub LRKSHLAkEGLYQYk
Y72 HLAkEGLYQYkNICQ
K75-ub kEGLYQYkNICQQVN
K183-ac DIAQQAFkFCLQYTR
S261 EDIHGLFSLSKKPPK
Y275-p KPQLMANyyNKVSTV
Y276-p PQLMANyyNKVSTVF
K285 KVSTVFWKSGNALFH
K308-ub HLSREMRkNLTQEEM
T311 REMRkNLTQEEMQRM
T326 STRVLLATLSIPItP
S328 RVLLATLSIPItPER
T332-p ATLSIPItPERtDIA
T336-p IPItPERtDIARLLD
K351-ub MDGIIVEkQRRLATL
Y382-p VRFSVLQyVVPEVKD
K402-ub EVEFNPLkLCERVTk
K409-ub kLCERVTkVLNWVRE
K420-ub WVREQPEkEPELQQY
S492 DHTSRTLSFGSDLNY
S528 NQLTAMSSVLAkALE
K532-ub AMSSVLAkALEVIRP
K559-ub LAVNAYLkNSRKEHQ
T574-p RILARRQtIEERkER
K579-ub RQtIEERkERLEsLN
S584-p ERkERLEsLNIQREk
K591-ub sLNIQREkEELEQRE
K603-ub QREAELQkVRKAEEE
K632 LQEHEQIKKKTVRER
K632 LQEHEQIKKKTVRER
K633 QEHEQIKKKTVRERL
K633 QEHEQIKKKTVRERL
K634 EHEQIKKKTVRERLE
T635 HEQIKKKTVRERLEQ
T646 RLEQIKKTELGAkAF
K651-ub KKTELGAkAFkDIDI
K654-ub ELGAkAFkDIDIEDL
K672-ub DPDFIMAkQVEQLEK
K682 EQLEKEKKELQERLK
K693 ERLKNQEKkIDYFER
K694 RLKNQEKKIDYFERA
K694-ub RLKNQEKkIDYFERA
K711-ub LEEIPLIkSAYEEQR
K720 AYEEQRVKDMDLWEQ
K775-ac RQSVYEEkLkQFEER
K775-ub RQSVYEEkLkQFEER
K777-ub SVYEEkLkQFEERLA
K824-ub RAEEQMLkEREERER
Y844 REEELREYQERVKKL
D881 EERRLGDDPLSRKDS
P882 ERRLGDDPLSRKDSR
S884 RLGDDPLSRKDSRWG
S888 DPLSRKDSRWGDRDS
S895 SRWGDRDSEGTWRKG
T898 GDRDSEGTWRKGPEA
S949 DDEERESSLRPDDDR
T982-p DRFSRRGtDDDRPSW
S1028 GLDDERGSWRTADED
S1059-p GADDERSsWRNADDD
K1135 GPWRPFVKPGGWREK
S1149-p KEKAREEsWGPPRES
S1159 PPRESRPSEEREWDR
S1217 RRGPAEESSSWRDSS
S1218 RGPAEESSSWRDSSR
S1223 ESSSWRDSSRRDDRD
S1273 SEREEASSWRRTDDR
T1285-p DDRKDDRtEERDPPR
S1300-p RVPPPALsRDRERER
K1313 EREREGEKEKASWRA
S1317 EGEKEKASWRAEKDR
S1326-p RAEKDREsLRRTKNE
T1330 DREsLRRTKNETDED
T1334 LRRTKNETDEDGWTT
T1340 ETDEDGWTTVRR___
T1341 TDEDGWTTVRR____
  rat

 
Y4 ____MPAYFQRPENA
K13 QRPENALKRANEFLE
K13 QRPENALKRANEFLE
K23 NEFLEVGKKQPALDV
K24 EFLEVGKKQPALDVL
Y32 QPALDVLYDVMKSKK
K45 KKHRTWQKIHEPIML
K68 LRKSHLAKEGLYQYK
K68 LRKSHLAKEGLYQYK
Y72 HLAKEGLYQYKNICQ
K75 KEGLYQYKNICQQVN
K183 DIAQQAFKFCLQYTR
S261 EDIHGLFSLSKKPPK
Y275 KPQLMANYYNKVSTV
Y276 PQLMANYYNKVSTVF
K285 KVSTVFWKSGNALFH
K308 HLSREMRKNLTQDEM
T311 REMRKNLTQDEMQRM
T326 STRVLLATLSIPITP
S328 RVLLATLSIPITPER
T332 ATLSIPITPERTDIA
T336 IPITPERTDIARLLD
K351 MDGIIVEKQRRLATL
Y382-p VRFNVLQyVVPEVKD
K402 EVEFNPLKLCERVTK
K409 KLCERVTKVLNWVRE
K420-ub WVREQPEkEPELQQY
S492 DHTSRTLSFGSDLNY
S528 NQLTAMSSVLAKALE
K532 AMSSVLAKALEVIKP
K559 LAVTAYIKNSRKEHQ
T574-p RILARRQtIEERKER
K579 RQtIEERKERLEsLN
S584-p ERKERLEsLNIQREK
K591 sLNIQREKEELEQRE
K603 QREAELQKVRKAEEE
K632 LQEHEQIKKKTVRER
K632 LQEHEQIKKKTVRER
K633 QEHEQIKKKTVRERL
K633 QEHEQIKKKTVRERL
K634 EHEQIKKKTVRERLE
T635 HEQIKKKTVRERLEQ
T646 RLEQIKKTELGAKAF
K651 KKTELGAKAFKDIDI
K654 ELGAKAFKDIDIEDL
K672 DPDFIMAKQVEQLEK
K682 EQLEKEKKELQERLK
K693 ERLKNQEKKIDYFER
K694 RLKNQEKKIDYFERA
K694 RLKNQEKKIDYFERA
K711 LEEIPLIKSAYEEQR
K720 AYEEQRVKDMDLWEQ
K775 RQSVYEEKLKQFEER
K775 RQSVYEEKLKQFEER
K777 SVYEEKLKQFEERLA
K824 RAEEQMLKEREERER
Y844 REEELREYQERVKKL
D881 EERRLGEDPLSRKDS
P882 ERRLGEDPLSRKDSR
S884 RLGEDPLSRKDSRWG
S888 DPLSRKDSRWGDRDS
S895 SRWGDRDSEGTWRKG
T898 GDRDSEGTWRKGPEA
S949 DDEERESSLRPDDDR
T982 DRFSRRGTDDDRPSW
S1038 GLDDERGSWRTAEED
S1069 GADDERSSWRNADDD
K1145 GPWRPFVKPGGWREK
S1159 KEKAREESWGPPRES
P1169 PPRESRPPEEREWDR
S1227 RRGPAEESSSWRDSS
S1228 RGPAEESSSWRDSSR
S1233 ESSSWRDSSRRDDRD
S1283 SEREEASSWRRTDDR
T1295 DDRKDDRTEERDPPR
S1310 RVPPPTLSRERERER
K1323 ERDREGEKEKASWRA
S1327 EGEKEKASWRAEKDR
S1336 RAEKDRESLRRTKNE
T1340 DRESLRRTKNETDED
T1344 LRRTKNETDEDGWTT
T1350 ETDEDGWTTVRR___
T1351 TDEDGWTTVRR____
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