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NuaK1 (human)

Overview NuaK1 a protein kinase of the CAMKL family. Phosphorylated and activated by AKT1 during glucose starvation. May activate ATM kinase under conditions of nutrient starvation. Suppresses apoptosis induced by nutrient starvation and death receptors via inhibition of caspase 8 activation. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; EC 2.7.11.1; CAMK group; CAMKL family; NuaK subfamily Cellular Component: cytoplasm; nucleus Molecular Function: protein serine/threonine kinase activity; protein binding; p53 binding; metal ion binding; ATP binding Biological Process: regulation of cell adhesion; cell adhesion; response to DNA damage stimulus; regulation of cell proliferation Reference #:  O60285 (UniProtKB) Alt. Names/Synonyms: AMP-activated protein kinase family member 5; AMPK-related protein kinase 5; ARK5; KIAA0537; NUAK family SNF1-like kinase 1; NUAK family, SNF1-like kinase, 1; NUAK1 Gene Symbols: NUAK1 Molecular weight: 74,305 Da Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NuaK1

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	Sites Implicated In
cell cycle regulation: T211‑p cell growth, altered: T211‑p cell growth, inhibited: T211‑p cell motility, altered: S600‑p activation: S600‑p enzymatic activity, induced: T211‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S22-p	LGLGAPGsPREAVAG
0	1		S85	GRVVAIKSIRKDKIK
0	2		Y141-p	YASKGELyDYIsERR
0	2		S145-p	GELyDYIsERRRLSE
5	1		T211-p	QKDKFLQtFCGSPLY
0	1		R284-m1	SDARGLIrWMLMVNP
0	1		T356-p	MKGLAKPtTSEVMLE
0	5		S367-p	VMLERQRsLKKSKKE
0	2		S388-p	GQDAVPEsPSKLSSK
0	1		S445-p	TGVLLPSsPEAEVPG
0	5		S455-p	AEVPGKLsPKQSATM
0	1		S499-p	DSNDVMGsSIPSPSP
0	1		S516-p	PARVTSHsLsCRRKG
0	1		S518-p	RVTSHsLsCRRKGIL
0	2		S562-p	GVPAEGLsRsYSRPS
0	2		S564-p	PAEGLsRsYSRPSSV
4	0		S600-p	PARQRIRsCVSAENF
0	1		T641	DSSFSLLTDMDDVTQ

	mouse
S22	VETGLPGSPLEAVAG
S86-p	GRVVAIKsIRKDKIK
Y142-p	YASKGELyDYIsERR
S146-p	GELyDYIsERRRLSE
T212	QKDKFLQTFCGSPLY
R285	SDARGLIRWMLMVNP
G357	MKGLAKPGASEVVLE
S368-p	VVLERQRsLKKSKKE
S389	GQDSVPESPSKLSSK
S446	TAIPLPSSPEADMSG
S456	ADMSGKLSLKQSATM
S500	DSNDVVISGGLSSPP
S517	PARGTSHSLSCRRKG
S519	RGTSHSLSCRRKGIL
S563-p	GVPSDGIsRsYSRPS
S565-p	PSDGIsRsYSRPSSI
S601	PARQRIRSCVSAENF
T638-p	DSSFSLLtDMDDVTQ

	rat
S22	VETGLPGSPREVVAG
S86	GRVVAIKSIRKDKIK
Y142	YASKGELYDYISERR
S146	GELYDYISERRRLSE
T212	QKDKFLQTFCGSPLY
R285	SDARGLIRWMLMVNP
G355	AKMKAKPGASEVVLE
S366	VVLERQRSLKKSKKE
S387-p	GQDSLPEsPSKLSSK
S444	TAIPLPGSPEAQGSS
S455	QGSSGKLSLKQSATM
S499	DSNNVIISSGLSSPP
S516	PARGTSHSLSCRRKG
S518	RGTSHSLSCRRKGIL
S562	GVPSDGISRSYSRPS
S564	PSDGISRSYSRPSSI
S600	PARQRIRSCVSAENF
A641	DSSFSLLADMDDVTQ

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