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Protein Page:
NuaK1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NuaK1 a protein kinase of the CAMKL family. Phosphorylated and activated by AKT1 during glucose starvation. May activate ATM kinase under conditions of nutrient starvation. Suppresses apoptosis induced by nutrient starvation and death receptors via inhibition of caspase 8 activation. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMKL family; NuaK subfamily
Cellular Component: microtubule cytoskeleton; cytoplasm; nucleolus; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; p53 binding; metal ion binding; ATP binding
Biological Process: regulation of cell adhesion; cell adhesion; protein amino acid phosphorylation; response to DNA damage stimulus; regulation of cell proliferation
Reference #:  O60285 (UniProtKB)
Alt. Names/Synonyms: AMP-activated protein kinase family member 5; AMPK-related protein kinase 5; ARK5; KIAA0537; NUAK family SNF1-like kinase 1; NUAK family, SNF1-like kinase, 1; NUAK1
Gene Symbols: NUAK1
Molecular weight: 74,305 Da
Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NuaK1

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: T211‑p
cell growth, altered: T211‑p
cell growth, inhibited: T211‑p
cell motility, altered: S600‑p
activity, induced: S600‑p
enzymatic activity, induced: T211‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S22-p LGLGAPGsPREAVAG
0 1 S85 GRVVAIKSIRKDKIK
0 2 Y141-p YASKGELyDYIsERR
0 2 S145-p GELyDYIsERRRLSE
5 1 T211-p QKDKFLQtFCGSPLY
0 1 R284-m1 SDARGLIrWMLMVNP
0 1 T356-p MKGLAKPtTSEVMLE
0 5 S367 VMLERQRSLKKSKKE
0 1 S388-p GQDAVPEsPSKLSSK
0 1 S444-p RTGVLLPssPEAEVP
1 2 S445-p TGVLLPssPEAEVPG
0 6 S455-p AEVPGKLsPKQsATM
0 1 S459-p GKLsPKQsATMPKKG
1 0 S476-p KKTQQREsGYYsSPE
1 0 S480-p QREsGYYsSPERSES
0 1 S499-p DSNDVMGsSIPSPSP
0 1 S516-p PARVTSHsLsCRRKG
0 1 S518-p RVTSHsLsCRRKGIL
0 2 S562-p GVPAEGLsRsYSRPS
0 2 S564-p PAEGLsRsYSRPSSV
4 0 S600-p PARQRIRsCVSAENF
0 1 T641 DSSFSLLTDMDDVTQ
  mouse

 
S22 VETGLPGSPLEAVAG
S86-p GRVVAIKsIRKDKIK
Y142-p YASKGELyDYIsERR
S146-p GELyDYIsERRRLSE
T212 QKDKFLQTFCGSPLY
R285 SDARGLIRWMLMVNP
G357 MKGLAKPGASEVVLE
S368-p VVLERQRsLKKSKKE
S389 GQDSVPESPSKLSSK
S445 RTAIPLPSSPEADMS
S446 TAIPLPSSPEADMSG
S456 ADMSGKLSLKQSATM
S460 GKLSLKQSATMPKKG
S477 KKTQQRESGYYSSPE
S481 QRESGYYSSPERSES
S500 DSNDVVISGGLSSPP
S517 PARGTSHSLSCRRKG
S519 RGTSHSLSCRRKGIL
S563-p GVPSDGIsRsYSRPS
S565-p PSDGIsRsYSRPSSI
S601 PARQRIRSCVSAENF
T638-p DSSFSLLtDMDDVTQ
  rat

 
S22 VETGLPGSPREVVAG
S86 GRVVAIKSIRKDKIK
Y142 YASKGELYDYISERR
S146 GELYDYISERRRLSE
T212 QKDKFLQTFCGSPLY
R285 SDARGLIRWMLMVNP
G355 AKMKAKPGASEVVLE
S366 VVLERQRSLKKSKKE
S387 GQDSLPESPSKLSSK
- gap
S444 TAIPLPGSPEAQGSS
S455 QGSSGKLSLKQSATM
S459 GKLSLKQSATMPKKG
S476 KKTQQRESGYYSSPE
S480 QRESGYYSSPERSES
S499 DSNNVIISSGLSSPP
S516 PARGTSHSLSCRRKG
S518 RGTSHSLSCRRKGIL
S562 GVPSDGISRSYSRPS
S564 PSDGISRSYSRPSSI
S600 PARQRIRSCVSAENF
A641 DSSFSLLADMDDVTQ
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