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Protein Page:
NuaK1 (human)

Overview
NuaK1 a protein kinase of the CAMKL family. Phosphorylated and activated by AKT1 during glucose starvation. May activate ATM kinase under conditions of nutrient starvation. Suppresses apoptosis induced by nutrient starvation and death receptors via inhibition of caspase 8 activation. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Protein kinase, CAMK; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMKL family; NuaK subfamily
Cellular Component: microtubule cytoskeleton; cytoplasm; nucleolus; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; p53 binding; metal ion binding; ATP binding
Biological Process: regulation of cell adhesion; cell adhesion; response to DNA damage stimulus; regulation of cell proliferation
Reference #:  O60285 (UniProtKB)
Alt. Names/Synonyms: AMP-activated protein kinase family member 5; AMPK-related protein kinase 5; ARK5; KIAA0537; NUAK family SNF1-like kinase 1; NUAK family, SNF1-like kinase, 1; NUAK1
Gene Symbols: NUAK1
Molecular weight: 74,305 Da
Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NuaK1

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: T211‑p
cell growth, altered: T211‑p
cell growth, inhibited: T211‑p
cell motility, altered: S600‑p
activity, induced: S600‑p
enzymatic activity, induced: T211‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S22-p LGLGAPGsPREAVAG
0 2 Y141-p YASKGELyDYIsERR
0 2 S145-p GELyDYIsERRRLSE
5 1 T211-p QKDKFLQtFCGSPLY
0 5 S367 VMLERQRSLKKSKKE
0 2 S388-p GQDAVPEsPSKLSSK
0 1 S445-p TGVLLPSsPEAEVPG
0 5 S455-p AEVPGKLsPKQSATM
0 2 S562-p GVPAEGLsRsYSRPS
0 2 S564-p PAEGLsRsYSRPSSV
4 0 S600-p PARQRIRsCVSAENF
0 1 T641 DSSFSLLTDMDDVTQ
  mouse

 
S22 VETGLPGSPLEAVAG
Y142-p YASKGELyDYIsERR
S146-p GELyDYIsERRRLSE
T212 QKDKFLQTFCGSPLY
S368-p VVLERQRsLKKSKKE
S389 GQDSVPESPSKLSSK
S446 TAIPLPSSPEADMSG
S456 ADMSGKLSLKQSATM
S563-p GVPSDGIsRsYSRPS
S565-p PSDGIsRsYSRPSSI
S601 PARQRIRSCVSAENF
T638-p DSSFSLLtDMDDVTQ
  rat

 
S22 VETGLPGSPREVVAG
Y142 YASKGELYDYISERR
S146 GELYDYISERRRLSE
T212 QKDKFLQTFCGSPLY
S366 VVLERQRSLKKSKKE
S387-p GQDSLPEsPSKLSSK
S444 TAIPLPGSPEAQGSS
S455 QGSSGKLSLKQSATM
S562 GVPSDGISRSYSRPS
S564 PSDGISRSYSRPSSI
S600 PARQRIRSCVSAENF
A641 DSSFSLLADMDDVTQ
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