Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
NAA10 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NAA10 In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Interacts with HIF1A (via its ODD domain); the interaction increases HIF1A protein stability during normoxia, and down-regulates it when induced by hypoxia. Interacts with NAA15, NAA50 and with the ribosome. Binds to MYLK. Ubiquitous. Belongs to the acetyltransferase family. ARD1 subfamily. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - phenylalanine; EC 2.3.1.-; EC 2.3.1.88; Acetyltransferase; Secondary Metabolites Metabolism - limonene and pinene degradation; Lipid Metabolism - glycerophospholipid; Amino Acid Metabolism - tyrosine
Cellular Component: membrane; cytoplasm; nucleolus; intracellular; nucleus
Molecular Function: peptide alpha-N-acetyltransferase activity; protein binding; N-acetyltransferase activity; acetyltransferase activity; ribosome binding
Biological Process: N-terminal protein amino acid acetylation; internal protein amino acid acetylation; DNA packaging
Reference #:  P41227 (UniProtKB)
Alt. Names/Synonyms: ARD1; ARD1 homolog A, N-acetyltransferase; ARD1 homolog, N-acetyltransferase; ARD1A; DXS707; MGC71248; N(alpha)-acetyltransferase 10, NatA catalytic subunit; N-acetyltransferase ARD1, human homolog of; N-alpha-acetyltransferase 10, NatA catalytic subunit; N-terminal acetyltransferase complex ARD1 subunit homolog A; NAA10; OTTHUMP00000026001; OTTHUMP00000026002; OTTHUMP00000064808; OTTHUMP00000064809; OTTHUMP00000180622; OTTHUMP00000180623; TE2
Gene Symbols: NAA10
Molecular weight: 26,459 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NAA10

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y26-p LLCLPENyQMKYYFY
0 1 T73-p DVPHGHItsLAVkRS
0 1 S74-p VPHGHItsLAVkRSH
0 2 K78-ub HItsLAVkRSHRRLG
0 9 K89-ub RRLGLAQkLMDQASR
1 12 K136-ac QISEVEPkyyADGED
0 11 Y137-p ISEVEPkyyADGEDA
0 8 Y138-p SEVEPkyyADGEDAy
0 99 Y145-p yADGEDAyAMkRDLT
0 5 K148-ac GEDAyAMkRDLTQMA
0 11 K148-ub GEDAyAMkRDLTQMA
0 2 K165-ub LRRHLELkEKGRHVV
0 1 K165-sc LRRHLELkEKGRHVV
0 1 K179-ub VLGAIENkVEsKGNs
0 15 S182-p AIENkVEsKGNsPPs
0 12 S186-p kVEsKGNsPPssGEA
0 3 S189-p sKGNsPPssGEACRE
0 2 S190-p KGNsPPssGEACREE
0 13 S205-p KGLAAEDsGGDsKDL
0 2 S209-p AEDsGGDsKDLsEVs
0 9 S213-p GGDsKDLsEVsETTE
0 5 S216-p sKDLsEVsETTEStD
0 1 T222-p VsETTEStDVKDssE
0 3 S227-p EStDVKDssEAsDSA
0 7 S228-p StDVKDssEAsDSAS
0 3 S231-p VKDssEAsDSAS___
0 1 S235 sEAsDSAS_______
  mouse

 
Y26 LLCLPENYQMKYYFY
T73 DVPHGHITSLAVKRS
S74 VPHGHITSLAVKRSH
K78 HITSLAVKRSHRRLG
K89-ub RRLGLAQkLMDQASR
K136-ac QISEVEPkyyADGED
Y137-p ISEVEPkyyADGEDA
Y138-p SEVEPkyyADGEDAy
Y145-p yADGEDAyAMkRDLT
K148 GEDAyAMKRDLTQMA
K148-ub GEDAyAMkRDLTQMA
K165 LRRHLELKEKGKHMV
K165 LRRHLELKEKGKHMV
K179 VLAALENKAENKGNV
N182 ALENKAENKGNVLLS
V186 KAENKGNVLLSSGEA
S189 NKGNVLLSSGEACRE
S190 KGNVLLSSGEACREE
S205-p KGLAAEDsGGDSKDL
S209 AEDsGGDSKDLSEVS
S213 GGDSKDLSEVSETTE
S216 SKDLSEVSETTESTD
T222 VSETTESTDVKDssE
S227-p ESTDVKDssEAsDSA
S228-p STDVKDssEAsDSAs
S231-p VKDssEAsDSAs___
S235-p sEAsDSAs_______
  rat

 
Y26 LLCLPENYQMKYYFY
T73 DVPHGHITSLAVKRS
S74 VPHGHITSLAVKRSH
K78 HITSLAVKRSHRRLG
K89 RRLGLAQKLMDQASR
K136 QISEVEPKYYADGED
Y137 ISEVEPKYYADGEDA
Y138 SEVEPKYYADGEDAY
Y145 YADGEDAYAMKRDLT
K148 GEDAYAMKRDLTQMA
K148 GEDAYAMKRDLTQMA
K165 LRRHLELKEKGRHMV
K165 LRRHLELKEKGRHMV
K179 VLSAMENKAENKGNV
N182 AMENKAENKGNVLLS
V186 KAENKGNVLLSSGEA
S189 NKGNVLLSSGEACRE
S190 KGNVLLSSGEACREE
S205 KGLTAEDSGGDSKDL
S209 AEDSGGDSKDLSEVS
S213 GGDSKDLSEVSETTE
S216 SKDLSEVSETTESTD
T222 VSETTESTDVKDSSE
S227 ESTDVKDSSEASDSA
S228 STDVKDSSEASDSAS
S231 VKDSSEASDSAS___
S235 SEASDSAS_______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.