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Protein Page:
NAA10 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NAA10 In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Interacts with HIF1A (via its ODD domain); the interaction increases HIF1A protein stability during normoxia, and down-regulates it when induced by hypoxia. Interacts with NAA15, NAA50 and with the ribosome. Binds to MYLK. Ubiquitous. Belongs to the acetyltransferase family. ARD1 subfamily. Note: This description may include information from UniProtKB.
Protein type: Lipid Metabolism - glycerophospholipid; EC 2.3.1.88; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine; Secondary Metabolites Metabolism - limonene and pinene degradation; Acetyltransferase
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: membrane; cytoplasm; nucleolus; intracellular; nucleus
Molecular Function: peptide alpha-N-acetyltransferase activity; N-acetyltransferase activity; protein binding; acetyltransferase activity; ribosome binding
Biological Process: N-terminal protein amino acid acetylation; N-terminal peptidyl-glutamic acid acetylation; internal protein amino acid acetylation; N-terminal peptidyl-serine acetylation; DNA packaging
Disease: Ogden Syndrome; Microphthalmia, Syndromic 1
Reference #:  P41227 (UniProtKB)
Alt. Names/Synonyms: ARD1; ARD1 homolog A, N-acetyltransferase; ARD1 homolog, N-acetyltransferase; ARD1A; DXS707; MGC71248; N(alpha)-acetyltransferase 10, NatA catalytic subunit; N-acetyltransferase ARD1, human homolog of; N-alpha-acetyltransferase 10, NatA catalytic subunit; N-terminal acetyltransferase complex ARD1 subunit homolog A; NAA10; OTTHUMP00000026001; OTTHUMP00000026002; OTTHUMP00000064808; OTTHUMP00000064809; OTTHUMP00000180622; OTTHUMP00000180623; TE2
Gene Symbols: NAA10
Molecular weight: 26,459 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NAA10

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 Y26-p LLCLPENyQMKYYFY
0 1 T73-p DVPHGHItsLAVkRS
0 1 S74-p VPHGHItsLAVkRSH
0 2 K78-ub HItsLAVkRSHRRLG
0 9 K89-ub RRLGLAQkLMDQASR
0 1 K105-ub MIENFNAkYVSLHVR
0 1 S131 NTLNFQISEVEPkyy
1 12 K136-ac QISEVEPkyyADGED
0 12 Y137-p ISEVEPkyyADGEDA
0 8 Y138-p SEVEPkyyADGEDAy
0 100 Y145-p yADGEDAyAMkRDLT
0 5 K148-ac GEDAyAMkRDLTQMA
0 11 K148-ub GEDAyAMkRDLTQMA
0 2 K165-ub LRRHLELkEKGRHVV
0 1 K165-sc LRRHLELkEKGRHVV
0 1 K179-ub VLGAIENkVEsKGNs
0 17 S182-p AIENkVEsKGNsPPs
0 15 S186-p kVEsKGNsPPssGEA
0 4 S189-p sKGNsPPssGEACRE
0 3 S190-p KGNsPPssGEACREE
0 18 S205-p KGLAAEDsGGDsKDL
0 3 S209-p AEDsGGDsKDLsEVs
0 11 S213-p GGDsKDLsEVsETTE
0 7 S216-p sKDLsEVsETTEStD
0 1 T222-p VsETTEStDVKDssE
0 3 S227-p EStDVKDssEAsDSA
0 8 S228-p StDVKDssEAsDSAS
0 3 S231-p VKDssEAsDSAS___
0 1 S235 sEAsDSAS_______
  NAA10 iso2  
Y26 LLCLPENYQMKYYFY
T73 DVPHGHITSLAVKRS
S74 VPHGHITSLAVKRSH
K78 HITSLAVKRSHRRLG
K89 RRLGLAQKLMDQASR
K105 MIENFNAKYVSLHVR
S116 LHVRKRISEVEPKYY
K121 RISEVEPKYYADGED
Y122 ISEVEPKYYADGEDA
Y123 SEVEPKYYADGEDAY
Y130 YADGEDAYAMKRDLT
K133 GEDAYAMKRDLTQMA
K133 GEDAYAMKRDLTQMA
K150 LRRHLELKEKGRHVV
K150 LRRHLELKEKGRHVV
K164 VLGAIENKVESKGNS
S167 AIENKVESKGNSPPS
S171 KVESKGNSPPSSGEA
S174 SKGNSPPSSGEACRE
S175 KGNSPPSSGEACREE
S190 KGLAAEDSGGDSKDL
S194 AEDSGGDSKDLSEVS
S198 GGDSKDLSEVSETTE
S201 SKDLSEVSETTESTD
T207 VSETTESTDVKDSSE
S212 ESTDVKDSSEASDSA
S213 STDVKDSSEASDSAS
S216 VKDSSEASDSAS___
S220 SEASDSAS_______
  mouse

 
Y26 LLCLPENYQMKYYFY
T73 DVPHGHITSLAVKRS
S74 VPHGHITSLAVKRSH
K78 HITSLAVKRSHRRLG
K89-ub RRLGLAQkLMDQASR
K105 MIENFNAKYVSLHVR
S131-p NTLNFQIsEVEPkyy
K136-ac QIsEVEPkyyADGED
Y137-p IsEVEPkyyADGEDA
Y138-p sEVEPkyyADGEDAy
Y145-p yADGEDAyAMkRDLT
K148 GEDAyAMKRDLTQMA
K148-ub GEDAyAMkRDLTQMA
K165 LRRHLELKEKGKHMV
K165 LRRHLELKEKGKHMV
K179 VLAALENKAENKGNV
N182 ALENKAENKGNVLLs
V186 KAENKGNVLLssGEA
S189-p NKGNVLLssGEACRE
S190-p KGNVLLssGEACREE
S205-p KGLAAEDsGGDsKDL
S209-p AEDsGGDsKDLSEVS
S213 GGDsKDLSEVSETTE
S216 sKDLSEVSETTESTD
T222 VSETTESTDVKDssE
S227-p ESTDVKDssEAsDSA
S228-p STDVKDssEAsDSAs
S231-p VKDssEAsDSAs___
S235-p sEAsDSAs_______
  rat

 
Y26 LLCLPENYQMKYYFY
T73 DVPHGHITSLAVKRS
S74 VPHGHITSLAVKRSH
K78 HITSLAVKRSHRRLG
K89 RRLGLAQKLMDQASR
K105 MIENFNAKYVSLHVR
S131 NTLNFQISEVEPKYY
K136 QISEVEPKYYADGED
Y137 ISEVEPKYYADGEDA
Y138 SEVEPKYYADGEDAY
Y145 YADGEDAYAMKRDLT
K148 GEDAYAMKRDLTQMA
K148 GEDAYAMKRDLTQMA
K165 LRRHLELKEKGRHMV
K165 LRRHLELKEKGRHMV
K179 VLSAMENKAENKGNV
N182 AMENKAENKGNVLLS
V186 KAENKGNVLLSSGEA
S189 NKGNVLLSSGEACRE
S190 KGNVLLSSGEACREE
S205 KGLTAEDSGGDSKDL
S209 AEDSGGDSKDLSEVS
S213 GGDSKDLSEVSETTE
S216 SKDLSEVSETTESTD
T222 VSETTESTDVKDSSE
S227 ESTDVKDSSEASDSA
S228 STDVKDSSEASDSAS
S231 VKDSSEASDSAS___
S235 SEASDSAS_______
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