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Protein Page:
CK2A1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CK2A1 an ubiquitous protein kinase of the CK2 family. Exists as a tetramer composed of two catalytic subunits, alpha and alpha-prime, and two regulatory beta subunits. The beta subunits undergo autophosphorylation. The isoforms are rarely specified in publications. Two splice variant isoforms have been found. Participates in Wnt signaling. Phosphorylates E2 ubiquitin conjugating enzyme UBC3B inducing its interaction with beta-TRCp and enhancing beta-catenin degradation. May control IkB-alpha and p27Kip1 degradation. component of a CK2-SPT16-SSRP1 complex composed of SSRP1, PT16 CK2-A1, CK2-A2 and CK2-B the complex associating following UV irradiation. Interacts with RNPS1. Mouse transgene causes mammary gland hyperplasia and lymphoma, and activation by bovine parasites leads to fatal lymphoproliferation. Expression and activity are elevated in lung tumors and breast tumors. Antisense drives apoptosis of tumor cell lines and xenografts. Involved in DNA break repair by phosphorylation of scaffold protein XRCC1, phosphorylation of BRCA1, and phosphorylation of p53 in response to UV irradiation. Drosophila CK2 (Timekeeper) is involved in circadian regulation. Phosphorylates and binds to a major component of the inclusion bodies seen in Parkinson?s patients. Inhibitors: 4,5,6,7-tetrabromobenzotriazole (TBB). Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Protein kinase, Other; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Other group; CK2 family
Cellular Component: Sin3 complex; plasma membrane; PcG protein complex; NuRD complex; nucleus; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; protein N-terminus binding; Hsp90 protein binding; ATP binding
Biological Process: axon guidance; Wnt receptor signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of protein catabolic process; negative regulation of caspase activity; mitotic cell cycle; signal transduction; positive regulation of cell growth; positive regulation of Wnt receptor signaling pathway; protein amino acid phosphorylation
Reference #:  P68400 (UniProtKB)
Alt. Names/Synonyms: casein kinase 2, alpha 1 polypeptide; casein kinase II alpha 1 subunit; Casein kinase II subunit alpha; CK II alpha; CK2 catalytic subunit alpha; CK2A1; CKII; CSK21; CSNK2A1; protein kinase CK2
Gene Symbols: CSNK2A1
Molecular weight: 45,144 Da
Basal Isoelectric point: 7.29  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  NF-kB Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CK2A1

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
enzymatic activity, induced: T360‑p, S362‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S2-p ______MsGPVPsRA
0 2 S7-p _MsGPVPsRARVYtD
1 0 T13-p PsRARVYtDVNTHRP
0 1 K49-u VRKLGRGkySEVFEA
0 3 Y50-p RKLGRGkySEVFEAI
1 1 K102-a ITLADIVkDPVSRTP
0 3 K102-u ITLADIVkDPVSRTP
0 2 K122-a HVNNTDFkQLYQtLT
0 2 K122-u HVNNTDFkQLYQtLT
0 1 T127-p DFkQLYQtLTDYDIR
1 0 Y182-p DWGLAEFyHPGQEYN
0 1 K229-u LASMIFRkEPFFHGH
0 2 K247-u DQLVRIAkVLGTEDL
2 14 Y255-p VLGTEDLyDYIDkYN
0 4 K260-u DLyDYIDkYNIELDP
0 1 S277-p NDILGRHsRKRWERF
0 1 S287-p RWERFVHsENQHLVS
0 1 S294 sENQHLVSPEALDFL
0 3 K329-u PYFYTVVkDQARMGS
1 0 T344-p SSMPGGStPVSSANM
2 0 T360-p SGISSVPtPsPLGPL
2 1 S362-p ISSVPtPsPLGPLAG
1 1 S370-p PLGPLAGsPVIAAAN
  mouse

 
S2 ______MSGPVPSRA
S7 _MSGPVPSRARVYTD
T13 PSRARVYTDVNTHRP
K49 VRKLGRGKYSEVFEA
Y50 RKLGRGKYSEVFEAI
K102 ITLADIVKDPVSRTP
K102-u ITLADIVkDPVSRTP
K122 HVNNTDFKQLYQTLT
K122 HVNNTDFKQLYQTLT
T127 DFKQLYQTLTDYDIR
Y182 DWGLAEFYHPGQEYN
K229 LASMIFRKEPFFHGH
K247-u DQLVRIAkVLGTEDL
Y255-p VLGTEDLyDYIDKYN
K260 DLyDYIDKYNIELDP
S277 NDILGRHSRKRWERF
S287-p RWERFVHsENQHLVs
S294-p sENQHLVsPEALDFL
K329-u PYFYTVVkDQARMSS
T344 TSMAGGSTPVSSANM
T360 SGISSVPTPSPLGPL
S362 ISSVPTPSPLGPLAG
S370 PLGPLAGSPVIAAAN
  rat

 
S2 ______MSGPVPSRA
S7 _MSGPVPSRARVYTD
T13 PSRARVYTDVNTHRP
K49 VRKLGRGKYSEVFEA
Y50 RKLGRGKYSEVFEAI
K102 ITLADIVKDPVSRTP
K102 ITLADIVKDPVSRTP
K122 HVNNTDFKQLYQTLT
K122 HVNNTDFKQLYQTLT
T127 DFKQLYQTLTDYDIR
Y182 DWGLAEFYHPGQEYN
K229 LASMIFRKEPFFHGH
K247 DQLVRIAKVLGTEDL
Y255 VLGTEDLYDYIDKYN
K260 DLYDYIDKYNIELDP
S277 NDILGRHSRKRWERF
S287 RWERFVHSENQHLVS
S294 SENQHLVSPEALDFL
K329 PYFYTVVKDQARMSS
T344 AGMAGGSTPVSSANM
T360 SGISSVPTPSPLGPL
S362 ISSVPTPSPLGPLAG
S370 PLGPLAGSPVIAAAN
  rabbit

 
S2 ______MSGPVPSRV
S7 _MSGPVPSRVRVYTD
T13 PSRVRVYTDVNTHRP
K49 VRKLGRGKYSEVFEA
Y50 RKLGRGKYSEVFEAI
K102 ITLADIVKDPASRTP
K102 ITLADIVKDPASRTP
K122 HVNNTDFKQLYQTLT
K122 HVNNTDFKQLYQTLT
T127 DFKQLYQTLTDYDIR
Y182 DWGLAEFYHPGQEYN
K229 LASMIFRKEPFFHGH
K247 DQLVRIAKVLGTEDL
Y255 VLGTEDLYDYIDKYN
K260 DLYDYIDKYNIELDP
S277 NDILGRHSRKRWERF
S287 RWERFVHSENQHLVS
S294 SENQHLVSPEALDFL
K329 PYFYTVVKDQARMGS
T344 SSMPGGSTPVSSANM
T360 SGISSVPTPSPLGPL
S362 ISSVPTPSPLGPLAG
S370 PLGPLAGSPVIAAAN
  cow

 
S2 ______MSGPVPSRA
S7 _MSGPVPSRARVYTD
T13 PSRARVYTDVNTHRP
K49 VRKLGRGKYSEVFEA
Y50 RKLGRGKYSEVFEAI
K102 ITLADIVKDPVSRTP
K102 ITLADIVKDPVSRTP
K122 HVNNTDFKQLYQTLT
K122 HVNNTDFKQLYQTLT
T127 DFKQLYQTLTDYDIR
Y182 DWGLAEFYHPGQEYN
K229 LASMIFRKEPFFHGH
K247 DQLVRIAKVLGTEDL
Y255 VLGTEDLYDYIDKYN
K260 DLYDYIDKYNIELDP
S277 NDILGRHSRKRWERF
S287 RWERFVHSENQHLVS
S294 SENQHLVSPEALDFL
K329 PYFYTVVKDQARMGS
T344 SSMPGGSTPVSSANM
T360 SGISSVPTPSPLGPL
S362 ISSVPTPSPLGPLAG
S370 PLGPLAGSPVIAAAN
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