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Protein Page:
GATA3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GATA3 a transcriptional regulator central in Th2 cell differentiation. Inhibits breast cancer growth and pulmonary breast cancer metastasis. Represses INK4C transcription, constrains luminal progenitor cell expansion, and suppresses luminal tumorigenesis in the mammary gland. High GATA3 and low INK4C expression predicts a favorable patient outcome in luminal A type breast tumors. IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human T cells. GATA3 haploinsufficiency leads to HDR (hypoparathyroidism, deafness, and renal dysplasia) syndrome. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 10p15
Cellular Component: nucleoplasm; nuclear chromatin; nucleolus; nucleus
Molecular Function: protein dimerization activity; protein binding; DNA binding; zinc ion binding; interleukin-2 receptor binding; transcription coactivator activity; transcription factor binding; transcription factor activity
Biological Process: developmental growth; positive regulation of transcription, DNA-dependent; cell maturation; ear development; cell fate determination; uterus development; T cell receptor signaling pathway; post-embryonic development; negative regulation of interleukin-2 production; norepinephrine biosynthetic process; regulation of neuron apoptosis; erythrocyte differentiation; anatomical structure formation; mesonephros development; kidney development; regulation of cytokine biosynthetic process; response to drug; thymic T cell selection; anatomical structure morphogenesis; inner ear morphogenesis; positive regulation of signal transduction; embryonic hemopoiesis; response to virus; negative regulation of fat cell differentiation; parathyroid gland development; negative regulation of mammary gland epithelial cell proliferation; response to ethanol; positive regulation of T cell differentiation; response to estrogen stimulus; positive regulation of transcription from RNA polymerase II promoter; pro-T cell differentiation; negative regulation of transcription, DNA-dependent; regulation of CD4-positive, alpha beta T cell differentiation; lens development in camera-type eye; transcription from RNA polymerase II promoter; axon guidance; phosphoinositide 3-kinase cascade; TOR signaling pathway; neuron migration; defense response; negative regulation of transcription from RNA polymerase II promoter; signal transduction; negative regulation of cell cycle; positive regulation of interleukin-4 production; negative regulation of cell proliferation; sympathetic nervous system development; negative regulation of interferon-gamma production; response to gamma radiation; type IV hypersensitivity; positive regulation of interleukin-13 production; positive regulation of interleukin-5 production; pharyngeal system development; thymus development; in utero embryonic development; male gonad development; humoral immune response; positive regulation of protein kinase B signaling cascade; negative regulation of inflammatory response; innate immune response; regulation of histone H3-K4 methylation; T-helper 2 cell differentiation; blood coagulation
Reference #:  P23771 (UniProtKB)
Alt. Names/Synonyms: GATA binding protein 3; GATA-binding factor 3; GATA3; HDR; MGC2346; MGC5199; MGC5445; Trans-acting T-cell-specific transcription factor GATA-3
Gene Symbols: GATA3
Molecular weight: 47,916 Da
Basal Isoelectric point: 9.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GATA3

Protein Structure Not Found.


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Sites Implicated In
transcription, induced: S308‑p
activity, induced: S308‑p
protein degradation: T156‑p
ubiquitination: T156‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 S110-p LGSHHTAsPWNLsPF
0 20 S115-p TAsPWNLsPFSKTSI
1 0 T156-p HLFTFPPtPPKDVsP
1 2 S162-p PtPPKDVsPDPSLST
0 1 Y186-p DEKECLKyQVPLPDS
0 1 T271-p VNCGATStPLWRRDG
0 2 Y282-p RRDGTGHyLCNACGL
0 3 Y290-p LCNACGLyHkMNGQN
1 0 K292-ac NACGLyHkMNGQNRP
1 0 K304-ac NRPLIKPkRRLsAAR
1 0 S308-p IKPkRRLsAARRAGT
1 0 K346-ac NACGLYYkLHNINRP
0 1 K358 NRPLTMKKEGIQTRN
0 28 S369-p QTRNRKMsSkSkkCk
0 1 K371-ac RNRKMsSkSkkCkKV
0 1 K373-ac RKMsSkSkkCkKVHD
0 1 K374-ac KMsSkSkkCkKVHDs
0 1 K376-ac sSkSkkCkKVHDsLE
0 2 S381-p kCkKVHDsLEDFPKN
0 1 S407 MSSLSHISPFSHSSH
  mouse

 
S109 LSSHHTASPWNLsPF
S114-p TASPWNLsPFSKTSI
T155-p HLFTFPPtPPKDVsP
S161-p PtPPKDVsPDPSLST
Y185 DEKECLKYQVQLPDS
T271 VNCGATSTPLWRRDG
Y282 RRDGTGHYLCNACGL
Y290 LCNACGLYHKMNGQN
K292 NACGLYHKMNGQNRP
K304 NRPLIKPKRRLSAAR
S308 IKPKRRLSAARRAGT
K346 NACGLYYKLHNINRP
K358-ac NRPLTMKkEGIQTRN
S369 QTRNRKMSSKSKKCK
K371 RNRKMSSKSKKCKKV
K373 RKMSSKSKKCKKVHD
K374 KMSSKSKKCKKVHDA
K376 SSKSKKCKKVHDALE
A381 KCKKVHDALEDFPKS
S407-p MSSLSHIsPFSHSSH
  rat

 
S110 LSSHHTASPWNLSPF
S115 TASPWNLSPFSKTSI
T156 HLFTFPPTPPKDVsP
S162-p PTPPKDVsPDPSLST
Y186 DEKECLKYQVQLPDS
T272 VNCGATSTPLWRRDG
Y283 RRDGTGHYLCNACGL
Y291 LCNACGLYHKMNGQN
K293 NACGLYHKMNGQNRP
K305 NRPLIKPKRRLSAAR
S309 IKPKRRLSAARRAGT
K347 NACGLYYKLHNINRP
K359 NRPLTMKKEGIQTRN
S370 QTRNRKMSSKSKKCK
K372 RNRKMSSKSKKCKKV
K374 RKMSSKSKKCKKVHD
K375 KMSSKSKKCKKVHDA
K377 SSKSKKCKKVHDALE
A382 KCKKVHDALEDFPKS
S408 MSSLSHISPFSHSSH
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