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Protein Page:
Casp1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Casp1 Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Interacts with CARD17/INCA and CARD18. Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. Specifically inhibited by the cowpox virus Crma protein. Belongs to the peptidase C14A family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protease; EC 3.4.22.36; Apoptosis
Cellular Component: cytoplasm; extracellular region; cytosol
Molecular Function: protein binding; cysteine-type endopeptidase activity; caspase activator activity
Biological Process: caspase activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; apoptosis; membrane hyperpolarization; interleukin-1 beta production; response to lipopolysaccharide; positive regulation of interleukin-1 beta secretion; mitochondrial depolarization; proteolysis; signal transduction; response to ATP; positive regulation of interleukin-1 alpha secretion; regulation of inflammatory response; response to hypoxia; innate immune response
Reference #:  P29466 (UniProtKB)
Alt. Names/Synonyms: CASP-1; CASP1; CASP1 nirs variant 1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase); Caspase-1; Caspase-1 subunit p10; Caspase-1 subunit p20; ICE; IL-1 beta-converting enzyme; IL-1BC; IL1B-convertase; IL1BC; IL1BCE; interleukin 1-B converting enzyme; interleukin 1-beta convertase; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45
Gene Symbols: CASP1
Molecular weight: 45,159 Da
Basal Isoelectric point: 5.63  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Casp1

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S376‑p

Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 K37-u LQTRVLNkEEMEKVK
0 13 K53-u ENATVMDkTRALIDS
0 9 K158-u EIYPIMDkSSRTRLA
0 6 K268-u IFNMLNTkNCPSLkD
0 7 K274-u TkNCPSLkDKPkVII
0 6 K278-u PSLkDKPkVIIIQAC
0 2 S302 FKDSVGVSGNLSLPT
0 12 K319-u EFEDDAIkkAHIEkD
0 5 K320-u FEDDAIkkAHIEkDF
0 8 K325-u IkkAHIEkDFIAFCS
0 1 M345 VSWRHPTMGSVFIGR
1 0 S376-p IFRKVRFsFEQPDGR
  mouse

 
Q37 LEKRVLNQEEMDKIK
K53 ANITAMDKARDLCDH
T157 EIYPIMNTTTRTRLA
L267 IFQMMNTLKCPSLKD
K273 TLKCPSLKDKPKVII
K277 PSLKDKPKVIIIQAC
S301-p LKDSVRDsEEDFLTD
K317 IFEDDGIKKAHIEKD
K318 FEDDGIKKAHIEKDF
K323 IKKAHIEKDFIAFCS
R343-m1 VSWRHPVrGSLFIES
S374 IFRKVRFSFEQPEFR
  rat

 
Q37 LEKRVLNQEEMDTIK
K53 ANITVMEKARDLCDH
T157 EIYPIMKTPTRTRLA
L267 IFQMMNTLKCPSLKD
K273 TLKCPSLKDKPKVII
K277 PSLKDKPKVIIIQAC
S301 LKDSVGNSEEGFLTD
K317 IFEDDGIKKAHIEKD
K318 FEDDGIKKAHIEKDF
K323 IKKAHIEKDFIAFCS
R343 VSWRHPVRGSLFIES
S374 IFRKVRFSFEQPDSR
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