Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
CASP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CASP1 Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Interacts with CARD17/INCA and CARD18. Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. Specifically inhibited by the cowpox virus Crma protein. Belongs to the peptidase C14A family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC 3.4.22.36; Protease
Cellular Component: cytoplasm; extracellular region; cytosol
Molecular Function: protein binding; cysteine-type endopeptidase activity; endopeptidase activity; caspase activator activity
Biological Process: caspase activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; apoptosis; membrane hyperpolarization; interleukin-1 beta production; response to lipopolysaccharide; positive regulation of interleukin-1 beta secretion; mitochondrial depolarization; signal transduction; proteolysis; response to ATP; positive regulation of interleukin-1 alpha secretion; regulation of inflammatory response; response to hypoxia; innate immune response
Reference #:  P29466 (UniProtKB)
Alt. Names/Synonyms: CASP-1; CASP1; CASP1 nirs variant 1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase); Caspase-1; Caspase-1 subunit p10; Caspase-1 subunit p20; ICE; IL-1 beta-converting enzyme; IL-1BC; IL1B-convertase; IL1BC; IL1BCE; interleukin 1-B converting enzyme; interleukin 1-beta convertase; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45
Gene Symbols: CASP1
Molecular weight: 45,159 Da
Basal Isoelectric point: 5.63  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CASP1

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
enzymatic activity, induced: S376‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S16-p KRKLFIRsMGEGtIN
0 1 T21-p IRsMGEGtINGLLDE
0 1 T32-p LLDELLQtRVLNkEE
0 3 K37-ub LQtRVLNkEEMEKVk
0 1 K44-ub kEEMEKVkRENATVM
0 13 K53-ub ENATVMDkTRALIDS
0 1 P121 PQAVQDNPAMPTSSG
0 1 K134-ub SGSEGNVkLCSLEEA
0 1 K148-ub AQRIWKQkSAEIYPI
0 9 K158-ub EIYPIMDkSSRTRLA
0 1 K204-ub GYSVDVKkNLTASDM
0 1 T226-p AHRPEHKtsDSTFLV
0 1 S227-p HRPEHKtsDSTFLVF
0 6 K268-ub IFNMLNTkNCPSLkD
0 7 K274-ub TkNCPSLkDKPkVII
0 6 K278-ub PSLkDKPkVIIIQAC
0 2 S302 FKDSVGVSGNLSLPT
0 12 K319-ub EFEDDAIkkAHIEkD
0 5 K320-ub FEDDAIkkAHIEkDF
0 8 K325-ub IkkAHIEkDFIAFCS
0 1 S339 SSTPDNVSWRHPTMG
0 1 T344 NVSWRHPTMGSVFIG
0 1 M345 VSWRHPTMGSVFIGR
1 0 S376-p IFRKVRFsFEQPDGR
  CASP1 iso4  
S16 KRKLFIRSMGEAPQA
- gap
- gap
- gap
- gap
- gap
P28 PQAVQDNPAMPTSSG
K41 SGSEGNVKLCSLEEA
K55 AQRIWKQKSAEIYPI
K65 EIYPIMDKSSRTRLA
K111 GYSVDVKKNLTASDM
T133 AHRPEHKTSDSTFLV
S134 HRPEHKTSDSTFLVF
K175 IFNMLNTKNCPSLKD
K181 TKNCPSLKDKPKVII
K185 PSLKDKPKVIIIQAC
- gap
- gap
- gap
- gap
S198-p ACRGDNVsWRHPtMG
T203-p NVsWRHPtMGSVFIG
M204 VsWRHPtMGSVFIGR
S235 IFRKVRFSFEQPDGR
  mouse

 
S16 KRKQFINSVSIGTIN
T21 INSVSIGTINGLLDE
K32 LLDELLEKRVLNQEE
Q37 LEKRVLNQEEMDKIK
K44 QEEMDKIKLANITAM
K53 ANITAMDKARDLCDH
K120-ac ETKEEQNkEDGTFPG
K133 PGLTGTLKFCPLEKA
N147 AQKLWKENPSEIYPI
T157 EIYPIMNTTTRTRLA
E203 GYTVKVKENLTALEM
T225 AACPEHKTSDSTFLV
S226 ACPEHKTSDSTFLVF
L267 IFQMMNTLKCPSLKD
K273 TLKCPSLKDKPKVII
K277 PSLKDKPKVIIIQAC
S301-p LKDSVRDsEEDFLTD
K317 IFEDDGIKKAHIEKD
K318 FEDDGIKKAHIEKDF
K323 IKKAHIEKDFIAFCS
S337 SSTPDNVSWRHPVrG
V342 NVSWRHPVrGSLFIE
R343-m1 VSWRHPVrGSLFIES
S374 IFRKVRFSFEQPEFR
  rat

 
S16 KRKQFINSVSVGTIN
T21 INSVSVGTINGLLDE
K32 LLDELLEKRVLNQEE
Q37 LEKRVLNQEEMDTIK
K44 QEEMDTIKLANITVM
K53 ANITVMEKARDLCDH
K120 ETKEKLNKEGGAFPG
K133 PGPSGSLKFCPLEIA
N147 AQKLWKENHSEIYPI
T157 EIYPIMKTPTRTRLA
E203 GYTVKVKENLTALEM
T225 AACPEHKTSDSTFLV
S226 ACPEHKTSDSTFLVF
L267 IFQMMNTLKCPSLKD
K273 TLKCPSLKDKPKVII
K277 PSLKDKPKVIIIQAC
S301 LKDSVGNSEEGFLTD
K317 IFEDDGIKKAHIEKD
K318 FEDDGIKKAHIEKDF
K323 IKKAHIEKDFIAFCS
S337 SSTPDNVSWRHPVRG
V342 NVSWRHPVRGSLFIE
R343 VSWRHPVRGSLFIES
S374 IFRKVRFSFEQPDSR
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.