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Protein Page:
dCK (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
dCK Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. Belongs to the DCK/DGK family. Note: This description may include information from UniProtKB.
Protein type: Nucleotide Metabolism - purine; Kinase, other; Nucleotide Metabolism - pyrimidine; EC 2.7.1.74
Cellular Component: cytosol; nucleus
Molecular Function: transferase activity; protein homodimerization activity; nucleoside kinase activity; deoxycytidine kinase activity; nucleotide binding; magnesium ion binding; pyrimidine deoxyribonucleoside binding; kinase activity; drug binding; phosphotransferase activity, alcohol group as acceptor; ATP binding
Biological Process: deoxycytidine metabolic process; nucleotide biosynthetic process; pyrimidine nucleotide metabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; drug metabolic process; phosphorylation; deoxyribonucleoside monophosphate biosynthetic process
Reference #:  P43346 (UniProtKB)
Alt. Names/Synonyms: Dck; Deoxycytidine kinase; OTTMUSP00000030586
Gene Symbols: Dck
Molecular weight: 30,367 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
Select Structure to View Below

dCK

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
3 3 T3 _____MATPPKRFCP
0 2 F8 MATPPKRFCPsPsts
4 18 S11-p PPKRFCPsPstssEG
0 13 S13-p KRFCPsPstssEGTR
0 3 T14-p RFCPsPstssEGTRI
4 11 S15-p FCPsPstssEGTRIK
0 4 S16-p CPsPstssEGTRIKK
0 2 T19 PstssEGTRIKKISI
0 1 K23 sEGTRIKKISIEGNI
0 2 K34 EGNIAAGKSTFVNIL
0 1 S35 GNIAAGKSTFVNILK
0 7 S63 ARWCNVQSTQEEFEE
0 6 T64 RWCNVQSTQEEFEEL
1 11 T72 QEEFEELTtsQKSGG
0 1 T73-p EEFEELTtsQKSGGN
10 100 S74-p EFEELTtsQKSGGNV
0 1 K88 VLQMMYEKPERWSFT
0 3 K115 QLASLNGKLkDAEkP
0 51 K117-ub ASLNGKLkDAEkPVL
0 5 K121-ub GKLkDAEkPVLFFER
0 1 Y190 EKCLNRIYLRGRNEE
0 1 Y204 EQGIPLEYLEKLHYK
0 1 K222 WLLHRTLKTSFDYLQ
0 17 K243-ub LDVNEDFkDkHESLV
0 1 K245-ub VNEDFkDkHESLVEK
0 1 K252 kHESLVEKVKEFLST
0 3 K252 kHESLVEKVKEFLST
  human

 
T3-p _____MAtPPKRsCP
S8-p MAtPPKRsCPsFsAs
S11-p PPKRsCPsFsAssEG
S13-p KRsCPsFsAssEGtR
A14 RsCPsFsAssEGtRI
S15-p sCPsFsAssEGtRIK
S16-p CPsFsAssEGtRIKk
T19-p FsAssEGtRIKkISI
K23-ub sEGtRIKkISIEGNI
K34-ub EGNIAAGksTFVNIL
S35-p GNIAAGksTFVNILK
S63-p ARWCNVQstQDEFEE
T64-p RWCNVQstQDEFEEL
T72-p QDEFEELtMsQKNGG
M73 DEFEELtMsQKNGGN
S74-p EFEELtMsQKNGGNV
K88-ac VLQMMYEkPERWSFT
K115-ub QLASLNGkLkDAEkP
K117-ub ASLNGkLkDAEkPVL
K121-ub GkLkDAEkPVLFFER
Y190-p ETCLHRIyLRGRNEE
Y204-p EQGIPLEyLEKLHYK
K222-ub WLLHRTLkTNFDYLQ
K243-ub LDVNEDFkDKYESLV
K245 VNEDFkDKYESLVEk
K252-ac KYESLVEkVKEFLST
K252-ub KYESLVEkVKEFLST
  rat

 
T3 _____MATPPKRFCS
F8 MATPPKRFCSsPSTS
S11-p PPKRFCSsPSTSSEG
S13 KRFCSsPSTSSEGTR
T14 RFCSsPSTSSEGTRI
S15 FCSsPSTSSEGTRIK
S16 CSsPSTSSEGTRIKK
T19 PSTSSEGTRIKKISI
K23 SEGTRIKKISIEGNI
K34 EGNIAAGKSTFVNIL
S35 GNIAAGKSTFVNILK
S63 ARWCNVQSTQDEFEE
T64 RWCNVQSTQDEFEEL
T72 QDEFEELTTSQKSGG
T73 DEFEELTTSQKSGGN
S74 EFEELTTSQKSGGNV
K88 VLQMMYEKPERWSFI
S115 QLASLNGSLRDAEKP
R117 ASLNGSLRDAEKPVL
K121 GSLRDAEKPVLFFER
Y190 EKCLNRIYIRGRDEE
Y204 EQGIPLEYLEKLHYK
K222 WLLHRTLKTNFEYLQ
K243 LDVNLDFKDKEESLV
K245 VNLDFKDKEESLVEK
K252 KEESLVEKVKEFLST
K252 KEESLVEKVKEFLST
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