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dCK (mouse)

Overview dCK Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. Belongs to the DCK/DGK family. Note: This description may include information from UniProtKB. Protein type: EC 2.7.1.74; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine Cellular Component: cytosol; nucleus Molecular Function: transferase activity; protein homodimerization activity; deoxycytidine kinase activity; magnesium ion binding; nucleotide binding; pyrimidine deoxyribonucleoside binding; drug binding; kinase activity; phosphotransferase activity, alcohol group as acceptor; ATP binding Biological Process: deoxycytidine metabolic process; nucleotide biosynthetic process; pyrimidine nucleotide metabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; drug metabolic process; phosphorylation Reference #:  P43346 (UniProtKB) Alt. Names/Synonyms: Dck; Deoxycytidine kinase; OTTMUSP00000030586 Gene Symbols: Dck Molecular weight: 30,367 Da Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states

Select Structure to View Below dCK 1P5Z - B=1-260 (human) 1P60 - A/B=1-260 (human) 1P61 - B=1-260 (human) 1P62 - B=1-260 (human) 2A2Z - A/B/C/D=1-260 (human) 2A30 - A/B/C/D=1-260 (human) 2A7Q - A=1-260 (human) 2NO0 - A/B=1-260 (human) 2NO1 - A/B=1-260 (human) 2NO6 - A/B=1-260 (human) 2NO7 - A/B=1-260 (human) 2NO9 - A/B=1-260 (human) 2NOA - A/B=1-260 (human) 2QRN - A/D/C/B=1-260 (human) 2QRO - A/D/C/B=1-260 (human) 2ZI3 - A/B=1-260 (human) 2ZI4 - A=1-260 (human) 2ZI5 - A/D/C/B=1-260 (human) 2ZI6 - A/D/C/B=1-260 (human) 2ZI7 - A/B=1-260 (human) 2ZI9 - A/B=1-260 (human) 2ZIA - A/B=1-260 (human) 3HP1 - A=1-260 (human) 3IPX - A=20-260 (human) 3IPY - A/B=20-260 (human) 3KFX - A/B=1-260 (human) 3MJR - A/D/C/B=1-260 (human) 3QEJ - A/B=1-260 (human) 3QEN - A/B=1-260 (human) 3QEO - A/B=1-260 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
3	3		T3	_____MATPPKRFCP
0	2		F8	MATPPKRFCPsPsts
4	16		S11-p	PPKRFCPsPstssEG
0	13		S13-p	KRFCPsPstssEGTR
0	2		T14-p	RFCPsPstssEGTRI
4	11		S15-p	FCPsPstssEGTRIK
0	4		S16-p	CPsPstssEGTRIKK
0	1		K23	sEGTRIKKISIEGNI
0	2		K34	EGNIAAGKSTFVNIL
0	1		S35	GNIAAGKSTFVNILK
0	7		S63	ARWCNVQSTQEEFEE
0	6		T64	RWCNVQSTQEEFEEL
1	12		T72	QEEFEELTtsQKSGG
0	1		T73-p	EEFEELTtsQKSGGN
9	101		S74-p	EFEELTtsQKSGGNV
0	1		K88	VLQMMYEKPERWSFT
0	3		K115	QLASLNGKLkDAEkP
0	51		K117-u	ASLNGKLkDAEkPVL
0	5		K121-u	GKLkDAEkPVLFFER
0	1		Y190	EKCLNRIYLRGRNEE
0	1		Y204	EQGIPLEYLEKLHYK
0	1		K222	WLLHRTLKTSFDYLQ
0	17		K243-u	LDVNEDFkDkHESLV
0	1		K245-u	VNEDFkDkHESLVEK
0	1		K252	kHESLVEKVKEFLST
0	3		K252	kHESLVEKVKEFLST

	human
T3-p	_____MAtPPKRsCP
S8-p	MAtPPKRsCPsFsAs
S11-p	PPKRsCPsFsAssEG
S13-p	KRsCPsFsAssEGTR
A14	RsCPsFsAssEGTRI
S15-p	sCPsFsAssEGTRIK
S16-p	CPsFsAssEGTRIKk
K23-u	sEGTRIKkISIEGNI
K34-u	EGNIAAGksTFVNIL
S35-p	GNIAAGksTFVNILK
S63-p	ARWCNVQstQDEFEE
T64-p	RWCNVQstQDEFEEL
T72-p	QDEFEELtMsQKNGG
M73	DEFEELtMsQKNGGN
S74-p	EFEELtMsQKNGGNV
K88-a	VLQMMYEkPERWSFT
K115-u	QLASLNGkLkDAEkP
K117-u	ASLNGkLkDAEkPVL
K121-u	GkLkDAEkPVLFFER
Y190-p	ETCLHRIyLRGRNEE
Y204-p	EQGIPLEyLEKLHYK
K222-u	WLLHRTLkTNFDYLQ
K243-u	LDVNEDFkDKYESLV
K245	VNEDFkDKYESLVEk
K252-a	KYESLVEkVKEFLST
K252-u	KYESLVEkVKEFLST

	rat
T3	_____MATPPKRFCS
F8	MATPPKRFCSsPSTS
S11-p	PPKRFCSsPSTSSEG
S13	KRFCSsPSTSSEGTR
T14	RFCSsPSTSSEGTRI
S15	FCSsPSTSSEGTRIK
S16	CSsPSTSSEGTRIKK
K23	SEGTRIKKISIEGNI
K34	EGNIAAGKSTFVNIL
S35	GNIAAGKSTFVNILK
S63	ARWCNVQSTQDEFEE
T64	RWCNVQSTQDEFEEL
T72	QDEFEELTTSQKSGG
T73	DEFEELTTSQKSGGN
S74	EFEELTTSQKSGGNV
K88	VLQMMYEKPERWSFI
S115	QLASLNGSLRDAEKP
R117	ASLNGSLRDAEKPVL
K121	GSLRDAEKPVLFFER
Y190	EKCLNRIYIRGRDEE
Y204	EQGIPLEYLEKLHYK
K222	WLLHRTLKTNFEYLQ
K243	LDVNLDFKDKEESLV
K245	VNLDFKDKEESLVEK
K252	KEESLVEKVKEFLST
K252	KEESLVEKVKEFLST

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