Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. Belongs to the DCK/DGK family. Note: This description may include information from UniProtKB.
Protein type: Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; EC 18.104.22.168; Kinase, other
Cellular Component: nucleus; cytosol
Molecular Function: transferase activity; protein homodimerization activity; nucleoside kinase activity; deoxycytidine kinase activity; nucleotide binding; magnesium ion binding; drug binding; pyrimidine deoxyribonucleoside binding; kinase activity; ATP binding
Biological Process: deoxycytidine metabolic process; pyrimidine nucleotide metabolic process; nucleotide biosynthetic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; drug metabolic process; phosphorylation; deoxyribonucleoside monophosphate biosynthetic process
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.