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STAT6
transcription factor of the STAT family. Plays a central role in IL4-mediated biological responses. Induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. May function in the differentiation of T helper 2 cells and class switch of immunoglobulins. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Note: This description may include information from UniProtKB.
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| Protein type: DNA binding protein; Transcription factor |
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Cellular Component: nuclear chromatin; cytoplasm; nucleolus; nucleus
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Molecular Function: identical protein binding; signal transducer activity; DNA binding; sequence-specific DNA binding; calcium ion binding; transcription factor activity
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Biological Process: T-helper 1 cell lineage commitment; negative regulation of T-helper 2 type immune response; response to cytokine stimulus; cytokine and chemokine mediated signaling pathway; mammary gland epithelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; signal transduction; positive regulation of isotype switching to IgE isotypes; regulation of cell proliferation
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Reference #:
NP_001037715 (RefSeq)
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| Alt. Names/Synonyms: signal transducer and activator of transcription 6; STAT6 |
| Gene Symbols: Stat6 |
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Molecular weight: 93,870 Da
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Basal Isoelectric point: 6.01
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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