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Protein Page:
UGT1A9 (human)

Overview
UGT1A9 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Carbohydrate Metabolism - pentose and glucuronate interconversions; EC 2.4.1.17; Carbohydrate Metabolism - starch and sucrose; Xenobiotic Metabolism - metabolism by cytochrome P450; Transferase; Xenobiotic Metabolism - drug metabolism - other enzymes; Carbohydrate Metabolism - ascorbate and aldarate; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Lipid Metabolism - androgen and estrogen; Endoplasmic reticulum; Cofactor and Vitamin Metabolism - retinol; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: enzyme inhibitor activity; protein homodimerization activity; retinoic acid binding; enzyme binding; protein heterodimerization activity; glucuronosyltransferase activity
Biological Process: metabolic process; xenobiotic metabolic process; negative regulation of catalytic activity; flavone metabolic process; retinoic acid metabolic process; cellular lipid metabolic process; negative regulation of fatty acid metabolic process; drug metabolic process
Reference #:  O60656 (UniProtKB)
Alt. Names/Synonyms: GNT1; HLUGP4; lugP4; UD19; UDP glucuronosyltransferase 1 family, polypeptide A9; UDP glycosyltransferase 1 family, polypeptide A9; UDP-glucuronosyltransferase 1-9; UDP-glucuronosyltransferase 1-I; UDP-glucuronosyltransferase 1A9; UDPGT; UDPGT 1-9; UGT-1I; UGT1; UGT1*9; UGT1-09; UGT1-9; UGT1.9; UGT1A9; UGT1AI; UGT1I
Gene Symbols: UGT1A9
Molecular weight: 59,941 Da
Basal Isoelectric point: 8.08  Predict pI for various phosphorylation states
Select Structure to View Below

UGT1A9

Protein Structure Not Found.


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