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Protein Page:
UGT1A9 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
UGT1A9 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - ascorbate and aldarate; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 2.4.1.17; Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Membrane protein, integral; Cofactor and Vitamin Metabolism - retinol; Endoplasmic reticulum; Lipid Metabolism - androgen and estrogen; Transferase; Xenobiotic Metabolism - drug metabolism - other enzymes; Carbohydrate Metabolism - pentose and glucuronate interconversions
Chromosomal Location of Human Ortholog: 2q37
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane
Molecular Function: enzyme inhibitor activity; protein homodimerization activity; retinoic acid binding; enzyme binding; glucuronosyltransferase activity; protein heterodimerization activity
Biological Process: negative regulation of transferase activity; flavonoid biosynthetic process; metabolic process; xenobiotic metabolic process; flavone metabolic process; retinoic acid metabolic process; negative regulation of fatty acid metabolic process; cellular lipid metabolic process; drug metabolic process; cellular response to hormone stimulus
Reference #:  O60656 (UniProtKB)
Alt. Names/Synonyms: GNT1; HLUGP4; lugP4; UD19; UDP glucuronosyltransferase 1 family, polypeptide A9; UDP glycosyltransferase 1 family, polypeptide A9; UDP-glucuronosyltransferase 1-9; UDP-glucuronosyltransferase 1-I; UDP-glucuronosyltransferase 1A9; UDPGT; UDPGT 1-9; UGT-1I; UGT1; UGT1*9; UGT1-09; UGT1-9; UGT1.9; UGT1A9; UGT1AI; UGT1I
Gene Symbols: UGT1A9
Molecular weight: 59,941 Da
Basal Isoelectric point: 8.08  Predict pI for various phosphorylation states
Select Structure to View Below

UGT1A9

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K434-ac VINDKSYkENIMRLS
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