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Protein Page:
XBP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
XBP1 a transcription factor essential for hepatocyte growth, the differentiation of plasma cells, immunoglobulin secretion, and the unfolded protein response (UPR). XBP1 mRNA is spliced by IRE1 during the UPR to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. Only the spliced form of XBP1 can activate the UPR efficiently. Activates UPR target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I. Up-regulated by ATF6 via direct binding to the ERSE in response to endoplasmic reticulum stress. Genetic variations in XBP1 could be associated with susceptibility to major affective disorder type 7 (MAFD7). Major affective disorders represent a class of mental disorders characterized by a disturbance in mood as their predominant feature. Two human isoforms are produced by alternative splicing. Isoform 1 is also known as XBP-1U. Isoform 2, also known as XBP-1S, is produced by IRE1 in response to endoplasmic reticulum stress. IRE1 cleaves a 26-bp fragment causing a frameshift of the mRNA transcript. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Chromosomal Location of Human Ortholog: 22q12.1|22q12
Cellular Component: nucleoplasm; endoplasmic reticulum; cytoplasm; integral to endoplasmic reticulum membrane; nucleus; cytosol
Molecular Function: protein binding; DNA binding; protease binding; chromatin DNA binding; protein heterodimerization activity; ubiquitin protein ligase binding; protein kinase binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; ubiquitin-dependent protein catabolic process; phosphoinositide 3-kinase cascade; exocrine pancreas development; positive regulation of transcription of target genes involved in unfolded protein response; regulation of protein stability; negative regulation of transcription from RNA polymerase II promoter; cellular response to glucose starvation; serotonin secretion, neurotransmission; positive regulation of MHC class II biosynthetic process; positive regulation of transcription factor import into nucleus; angiogenesis; response to electrical stimulus; cell growth; positive regulation of autophagy; positive regulation of TOR signaling pathway; response to drug; positive regulation of histone methylation; protein destabilization; unfolded protein response; cellular response to nutrient; positive regulation of immunoglobulin secretion; liver development; positive regulation of immunoglobulin production; cholesterol homeostasis; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; cellular response to insulin stimulus; positive regulation of T cell differentiation; fatty acid homeostasis; endothelial cell proliferation; positive regulation of fat cell differentiation; neuron development; positive regulation of B cell differentiation; immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; sterol homeostasis; vascular endothelial growth factor receptor signaling pathway; negative regulation of apoptosis
Reference #:  P17861 (UniProtKB)
Alt. Names/Synonyms: Tax-responsive element-binding protein 5; TREB5; X-box binding protein 1; X-box-binding protein 1; XBP-1; XBP1; XBP2
Gene Symbols: XBP1
Molecular weight: 28,695 Da
Basal Isoelectric point: 9.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

XBP1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 S47-p VPAQRGAsPEAASGG
1 0 L55 PEAASGGLPQARKRQ
2 2 S68-p RQRLTHLsPEEKALR
0 1 S96-p DRKKARMsELEQQVV
0 1 K111-ub DLEEENQkLLLENQL
0 6 K151-ub AEEEAEAkGNEVRPV
1 0 S181-p QQVQAQLsPLQNISP
0 1 K236-ub SSQRSTQkDPVPYQP
0 1 S255-p QWGRHQPsWKPLMN_
0 1 - gap
1 0 - gap
0 1 - under review  
1 0 - gap
  XBP1 iso2  
S47 VPAQRGASPEAASGG
L55 PEAASGGLPQARKRQ
S68 RQRLTHLSPEEKALR
S96 DRKKARMSELEQQVV
K111 DLEEENQKLLLENQL
K151 AEEEAEAKGNEVRPV
- gap
- gap
- gap
K262-ub RFDHIYTkPLVLEIP
K281 SQANVVVKIEEAPLs
S288-p KIEEAPLsPSENDHP
K302 PEFIVSVKEEPVEDD
  mouse

► Hide Isoforms
 
G42 VPGPRAAGSEASGtP
T48-p AGSEASGtPQARKRQ
S61-p RQRLTHLsPEEKALR
S89 DRKKARMSELEQQVV
K104 DLEEENHKLQLENQL
K146 EVPEVEAKGSGVRLV
S176 QQVQAQLSPPQNIFP
K231 NSQRSTQKDLVPYQP
S250 QWGPHQPSWKPLMNS
- gap
- gap
- under review  
- gap
  XBP1 iso2  
G42 VPGPRAAGSEASGTP
T48 AGSEASGTPQARKRQ
S61 RQRLTHLSPEEKALR
S89 DRKKARMSELEQQVV
K104 DLEEENHKLQLENQL
K146 EVPEVEAKGSGVRLV
- gap
- gap
- gap
K257 RFDHVYTKPLVLEIP
K276-sm SQTNVVVkIEEAPLS
S283 kIEEAPLSSSEEDHP
K297-sm PEFIVSVkKEPLEDD
  rat

 
G42 VPGPRAAGSEASGTP
T48 AGSEASGTPQARKRQ
S61 RQRLTHLSPEEKALR
S89 DRKKARMSELEQQVV
K104 DLEEENQKLQLENQL
K146 EVSEAESKGNGVRLV
S176 QQVQAQLSPPQNIFP
K231 NSQRSTQKDLVPYQP
S250 QWGPHQPSWKPLMNS
- gap
- gap
- under review  
- gap
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