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Protein Page:
TNFRSF25 (human)

Overview
TNFRSF25 Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis. Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4. Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate. 12 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Apoptosis; Receptor, misc.
Chromosomal Location of Human Ortholog: 1p36.2
Cellular Component: integral to plasma membrane; plasma membrane; extracellular region; cytosol
Molecular Function: tumor necrosis factor receptor activity; receptor activity
Biological Process: regulation of apoptosis; cell surface receptor linked signal transduction; tumor necrosis factor-mediated signaling pathway; apoptosis; signal transduction
Reference #:  Q93038 (UniProtKB)
Alt. Names/Synonyms: Apo-3; APO3; apoptosis inducing receptor; Apoptosis-inducing receptor AIR; Apoptosis-mediating receptor DR3; Apoptosis-mediating receptor TRAMP; DDR3; death domain receptor 3 soluble form; Death receptor 3; death receptor beta; DR3; LARD; lymphocyte associated receptor of death; Lymphocyte-associated receptor of death; Protein WSL; Protein WSL-1; TNFRSF12; TNFRSF25; TNR25; TR3; TRAMP; translocating chain-association membrane protein; Tumor necrosis factor receptor superfamily member 25; tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein); tumor necrosis factor receptor superfamily, member 25; WSL; WSL-1; WSL-LR; WSL1
Gene Symbols: TNFRSF25
Molecular weight: 45,385 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TNFRSF25

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T221 LLLGATLTYTYRHCW
0 1 - under review  
  TNFRSF25 iso11  
T230-p LLLGATLtYtYRHCW
T232-p LGATLtYtYRHCWPH
  mouse

 
I190 FLFGAILICAYCRWQ
A192 FGAILICAYCRWQPC
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