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IRAK1
a TKL kinase of the IRAK family. Involved in Toll/IL-1 signaling. One of two putative serine/threonine kinases that become associated with the interleukin-1 receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Extensively phosphorylated after its association with IL1-R-1. Polyubiquitinated; after cell stimulation with IL-1-beta. Polyubiquitination occurs with polyubiquitin chains linked through 'Lys-63'. Partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Three isoforms of the human protein and produced by alternative splicing. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1. Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2. Note: This description may include information from UniProtKB.
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| Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; EC 2.7.11.1; Kinase, protein; TKL group; IRAK family |
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Cellular Component: interleukin-1 receptor complex; plasma membrane; lipid particle; endosome membrane; nucleus; cytosol
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Molecular Function: NF-kappaB-inducing kinase activity; protein serine/threonine kinase activity; protein binding; interleukin-1 receptor binding; protein homodimerization activity; protein heterodimerization activity; ubiquitin-protein ligase activity; kinase activity; ATP binding; protein kinase activity
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Biological Process: nerve growth factor receptor signaling pathway; activation of MAPK activity; protein amino acid autophosphorylation; positive regulation of transcription, DNA-dependent; stress-activated MAPK cascade; protein ubiquitination; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; signal transduction; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; response to peptidoglycan; transmembrane receptor protein serine/threonine kinase signaling pathway; lipopolysaccharide-mediated signaling pathway; JNK cascade; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; activation of NF-kappaB-inducing kinase; Toll signaling pathway; protein oligomerization; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; inhibition of NF-kappaB transcription factor; toll-like receptor signaling pathway; regulation of cytokine and chemokine mediated signaling pathway; innate immune response
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Reference #:
P51617 (UniProtKB)
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| Alt. Names/Synonyms: Interleukin-1 receptor-associated kinase 1; IRAK; IRAK-1; IRAK1; pelle; Pelle homolog |
| Gene Symbols: IRAK1 |
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Molecular weight: 76,537 Da
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Basal Isoelectric point: 6.18
Predict pI for various phosphorylation states
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CST Pathways:
NF-kB Signaling
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Toll-like Receptors Pathway
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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