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Protein Page:
IRAK2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IRAK2 Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TKL; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); TKL group; IRAK family
Cellular Component: plasma membrane; endosome membrane; cytosol
Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; ATP binding; protein kinase activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; activation of MAPK activity; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; protein amino acid phosphorylation; toll-like receptor 2 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 10 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; inhibition of NF-kappaB transcription factor; lipopolysaccharide-mediated signaling pathway; toll-like receptor signaling pathway; innate immune response; regulation of cytokine and chemokine mediated signaling pathway; JNK cascade; toll-like receptor 9 signaling pathway; inflammatory response; toll-like receptor 4 signaling pathway
Reference #:  O43187 (UniProtKB)
Alt. Names/Synonyms: interleukin-1 receptor associated kinase-2; interleukin-1 receptor-associated kinase 2; Interleukin-1 receptor-associated kinase-like 2; IRAK-2; IRAK2; MGC150550
Gene Symbols: IRAK2
Molecular weight: 69,433 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IRAK2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y4-p ____MACyIyQLPSW
0 1 Y6-p __MACyIyQLPSWVL
0 1 R50 RKIKSMERVQGVSIT
0 2 T137 GQPVRMATFPGPGSs
0 2 P141 RMATFPGPGSsPARA
0 1 S144-p TFPGPGSsPARAHQP
0 1 S430-p YLKDLLLsDIPsSTA
0 1 S434-p LLLsDIPsSTAsLCS
0 1 S438-p DIPsSTAsLCSRKTG
0 1 K443 TAsLCSRKTGVENVM
0 1 K461-ac ICQKYLEkGAGRLPE
0 1 T508 ERLRGRETLLPWSGL
  mouse

 
Y4 ____MACYIYQLPSW
Y6 __MACYIYQLPSWVL
R50-m1 RKIKSMErVQGVSIT
S136-p VRPVKPRsLLDtGPI
T140-p KPRsLLDtGPIMAGA
- gap
S428 YLKDLLLSEIPNSTS
N432 LLLSEIPNSTSSVCS
S436 EIPNSTSSVCSRKTS
K441 TSSVCSRKTSMGKAV
K459 ICQRHVEKRAGLLPE
S506-p EQLRGQLsLPWSRVS
  rat

 
Y4 ____MACYIYQLPSW
Y6 __MACYIYQLPSWVL
R50 RKIKSMERVQGVSIT
S136 GQPVKPCSFLSSGTT
S140 KPCSFLSSGTTMAGA
T143 SFLSSGTTMAGAQQQ
S430 YLKDLLLSEIPSNTS
S434 LLLSEIPSNTSSVHS
S438 EIPSNTSSVHSRkTS
K443-ub TSSVHSRkTSMGKVV
R461 ICQKHLERKAGLLPE
S508 EQLRGQLSLPWSRVS
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