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Protein Page:
IRAK2 (human)

Overview
IRAK2 Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); TKL group; IRAK family
Cellular Component: plasma membrane; endosome membrane; cytosol
Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; ATP binding; protein kinase activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; activation of MAPK activity; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; activation of NF-kappaB transcription factor; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; inhibition of NF-kappaB transcription factor; toll-like receptor signaling pathway; lipopolysaccharide-mediated signaling pathway; innate immune response; JNK cascade; regulation of cytokine and chemokine mediated signaling pathway; toll-like receptor 9 signaling pathway; inflammatory response; toll-like receptor 4 signaling pathway
Reference #:  O43187 (UniProtKB)
Alt. Names/Synonyms: interleukin-1 receptor associated kinase-2; interleukin-1 receptor-associated kinase 2; Interleukin-1 receptor-associated kinase-like 2; IRAK-2; IRAK2; MGC150550
Gene Symbols: IRAK2
Molecular weight: 69,433 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
CST Pathways:  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IRAK2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T137 GQPVRMATFPGPGSs
0 1 P141 RMATFPGPGSsPARA
0 1 S144-p TFPGPGSsPARAHQP
  mouse

 
S136-p VRPVKPRsLLDtGPI
T140-p KPRsLLDtGPIMAGA
- gap
  rat

 
S136 GQPVKPCSFLSSGTT
S140 KPCSFLSSGTTMAGA
T143 SFLSSGTTMAGAQQQ
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