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IRAK2 (human)

Overview IRAK2 Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. Note: This description may include information from UniProtKB. Protein type: Protein kinase, TKL; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); TKL group; IRAK family Cellular Component: cell surface; plasma membrane; endosome membrane; cytosol Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; ATP binding; protein kinase activity Biological Process: I-kappaB kinase/NF-kappaB cascade; activation of MAPK activity; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; protein amino acid phosphorylation; Toll signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; activation of NF-kappaB transcription factor; MyD88-dependent toll-like receptor signaling pathway; inhibition of NF-kappaB transcription factor; lipopolysaccharide-mediated signaling pathway; toll-like receptor signaling pathway; regulation of cytokine and chemokine mediated signaling pathway; JNK cascade; innate immune response; inflammatory response; toll-like receptor 4 signaling pathway Reference #:  O43187 (UniProtKB) Alt. Names/Synonyms: interleukin-1 receptor associated kinase-2; interleukin-1 receptor-associated kinase 2; Interleukin-1 receptor-associated kinase-like 2; IRAK-2; IRAK2; MGC150550 Gene Symbols: IRAK2 Molecular weight: 69,433 Da Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states CST Pathways:  Toll-like Receptors Pathway Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IRAK2 3MOP - M/N/K/L=2-112 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y4-p	____MACyIyQLPSW
0	1		Y6-p	__MACyIyQLPSWVL
0	1		R50	RKIKSMERVQGVSIT
0	1		T137	GQPVRMATFPGPGSS
0	1		P141	RMATFPGPGSSPARA
0	1		S430-p	YLKDLLLsDIPsSTA
0	1		S434-p	LLLsDIPsSTAsLCS
0	1		S438-p	DIPsSTAsLCSRKTG
0	1		K443	TAsLCSRKTGVENVM
0	1		K461-a	ICQKYLEkGAGRLPE

	mouse
Y4	____MACYIYQLPSW
Y6	__MACYIYQLPSWVL
R50-m1	RKIKSMErVQGVSIT
S136-p	VRPVKPRsLLDtGPI
T140-p	KPRsLLDtGPIMAGA
S428	YLKDLLLSEIPNSTS
N432	LLLSEIPNSTSSVCS
S436	EIPNSTSSVCSRKTS
K441	TSSVCSRKTSMGKAV
K459	ICQRHVEKRAGLLPE

	rat
Y4	____MACYIYQLPSW
Y6	__MACYIYQLPSWVL
R50	RKIKSMERVQGVSIT
S136	GQPVKPCSFLSSGTT
S140	KPCSFLSSGTTMAGA
S430	YLKDLLLSEIPSNTS
S434	LLLSEIPSNTSSVHS
S438	EIPSNTSSVHSRkTS
K443-u	TSSVHSRkTSMGKVV
R461	ICQKHLERKAGLLPE

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