Home

ITGA4 (human)

Overview ITGA4 Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. Belongs to the integrin alpha chain family. Note: This description may include information from UniProtKB. Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Cellular Component: cell surface; plasma membrane; integrin complex; external side of plasma membrane Molecular Function: protein binding; metal ion binding; fibronectin binding Biological Process: heterophilic cell adhesion; integrin-mediated signaling pathway; leukocyte adhesion; regulation of immune response; heart development; B cell differentiation; blood vessel remodeling; blood coagulation; leukocyte migration Reference #:  P13612 (UniProtKB) Alt. Names/Synonyms: 269C wild type; antigen CD49D, alpha-4 subunit of VLA-4 receptor; CD49 antigen-like family member D; CD49D; IA4; integrin alpha 4; Integrin alpha-4; integrin alpha-4 subunit; Integrin alpha-IV; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); ITA4; ITGA4; MGC90518; very late activation protein 4 receptor, alpha 4 subunit; VLA-4 subunit alpha Gene Symbols: ITGA4 Molecular weight: 114,900 Da Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states CST Pathways:  GPCRs Signaling to MAPK/Erk  |  MAPK/Erk in Growth and Differentiation  |  PI3K/Akt Signaling  |  Regulation of Actin Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ITGA4 3V4P - A/C=34-620 (human) 3V4V - A/C=34-620 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3V4P 3V4V  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell motility, altered: S1021‑p cytoskeletal reorganization: S1021‑p activation: S1021‑p molecular association, regulation: S1011‑p, S1021‑p, Y1024‑p phosphorylation: S1021‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K95-u	IYRCRIGkNPGQTCE
0	1		K149-u	VTCGHRWkNIFYIKN
0	1		S634-p	CSADLQVsAKIGFLK
0	1		K771-u	VTVAIPLkYEVKLTV
0	2		K867-u	VCALEQQkSAMQTLK
0	1		T872	QQkSAMQTLKGIVRF
0	1		K874	kSAMQTLKGIVRFLS
0	1		S924-p	IQLEGRPsILEMDET
0	1		K1010	GFFKRQYKsILQEEN
1	1		S1011-p	FFKRQYKsILQEENR
6	108		S1021-p	QEENRRDsWsyINSk
0	8		S1023-p	ENRRDsWsyINSksN
2	3		Y1024-p	NRRDsWsyINSksND
0	8		K1028-u	sWsyINSksNDD___
0	2		S1029-p	WsyINSksNDD____

	mouse
K102	IYRCGIRKNPNQTCE
K156	VTCGHRWKNIFYMKS
S641	CSADLQVSAKVGFLK
R778	VTLTIPLRYEVMLTV
K874	ECTFAQQKGIAGtLt
T879-p	QQKGIAGtLtDIVKF
T881-p	KGIAGtLtDIVKFLS
S931	IQLEGRPSILEMDET
K1017-u	GFFKRQYkSILQEEN
S1018	FFKRQYkSILQEENR
S1028-p	QEENRRDsWsYVNSK
S1030-p	ENRRDsWsYVNSKSN
Y1031	NRRDsWsYVNSKSND
K1035	sWsYVNSKSNDD___
S1036	WsYVNSKSNDD____

	rat
K99	IYRCRIGKNPNQICE
K153	VTCGHRWKNIFYMKN
S638	CSADLQVSAKVGFLK
R775	VTLVIPLRYEVMLAV
K871	ECALAQQKGIAGTLT
T876	QQKGIAGTLTDLVKF
T878	KGIAGTLTDLVKFLS
S928	IQLEGRPSVLEMDET
K1014	GFFKRQYKSILQEEN
S1015	FFKRQYKSILQEENR
S1025	QEENRRDSWSYVNSK
S1027	ENRRDSWSYVNSKSN
Y1028	NRRDSWSYVNSKSND
K1032	SWSYVNSKSNDD___
S1033	WSYVNSKSNDD____

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.