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Protein Page:
ITGA4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ITGA4 Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. Belongs to the integrin alpha chain family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell adhesion; Receptor, misc.; Motility/polarity/chemotaxis
Cellular Component: cell surface; membrane; plasma membrane; integrin complex; external side of plasma membrane
Molecular Function: protein binding; metal ion binding; fibronectin binding; cell adhesion molecule binding
Biological Process: integrin-mediated signaling pathway; heterophilic cell adhesion; regulation of immune response; extracellular matrix organization and biogenesis; leukocyte adhesion; heart development; B cell differentiation; blood vessel remodeling; blood coagulation; leukocyte migration
Reference #:  P13612 (UniProtKB)
Alt. Names/Synonyms: 269C wild type; antigen CD49D, alpha-4 subunit of VLA-4 receptor; CD49 antigen-like family member D; CD49D; IA4; integrin alpha 4; Integrin alpha-4; integrin alpha-4 subunit; Integrin alpha-IV; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); ITA4; ITGA4; MGC90518; very late activation protein 4 receptor, alpha 4 subunit; VLA-4 subunit alpha
Gene Symbols: ITGA4
Molecular weight: 114,900 Da
Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ITGA4

Protein Structure Not Found.


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Sites Implicated In
cell motility, altered: S1021‑p
cytoskeletal reorganization: S1021‑p
activity, induced: S1021‑p
molecular association, regulation: S1011‑p, S1021‑p, Y1024‑p
phosphorylation: S1021‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K95-ub IYRCRIGkNPGQTCE
0 1 K149-ub VTCGHRWkNIFYIKN
0 1 S412-p GRADGISsTFSQRIE
0 1 S634-p CSADLQVsAKIGFLK
0 1 S734-p SFLLDVSsLSRAEED
0 1 K771-ub VTVAIPLkYEVKLTV
0 2 K867-ub VCALEQQkSAMQTLK
0 1 T872 QQkSAMQTLKGIVRF
0 1 K874 kSAMQTLKGIVRFLS
0 1 S924-p IQLEGRPsILEMDET
0 1 K1010 GFFKRQYKsILQEEN
1 1 S1011-p FFKRQYKsILQEENR
7 120 S1021-p QEENRRDsWsyINSk
0 11 S1023-p ENRRDsWsyINSksN
3 5 Y1024-p NRRDsWsyINSksND
0 8 K1028-ub sWsyINSksNDD___
0 2 S1029-p WsyINSksNDD____
  mouse

 
K102 IYRCGIRKNPNQTCE
K156 VTCGHRWKNIFYMKS
S419 GRVDGISSTYSQRIE
S641 CSADLQVSAKVGFLK
S741 SFLLDVSSLSRAHED
R778 VTLTIPLRYEVMLTV
K874 ECTFAQQKGIAGtLt
T879-p QQKGIAGtLtDIVKF
T881-p KGIAGtLtDIVKFLS
S931 IQLEGRPSILEMDET
K1017-ub GFFKRQYkSILQEEN
S1018 FFKRQYkSILQEENR
S1028-p QEENRRDsWsYVNSK
S1030-p ENRRDsWsYVNSKSN
Y1031 NRRDsWsYVNSKSND
K1035 sWsYVNSKSNDD___
S1036 WsYVNSKSNDD____
  rat

 
K99 IYRCRIGKNPNQICE
K153 VTCGHRWKNIFYMKN
S416 GRVDGISSTYSQRIE
S638 CSADLQVSAKVGFLK
S738 SFLLDVSSLSRAHED
R775 VTLVIPLRYEVMLAV
K871 ECALAQQKGIAGTLT
T876 QQKGIAGTLTDLVKF
T878 KGIAGTLTDLVKFLS
S928 IQLEGRPSVLEMDET
K1014 GFFKRQYKSILQEEN
S1015 FFKRQYKSILQEENR
S1025-p QEENRRDsWSYVNSK
S1027 ENRRDsWSYVNSKSN
Y1028 NRRDsWSYVNSKSND
K1032 sWSYVNSKSNDD___
S1033 WSYVNSKSNDD____
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