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Protein Page:
RARG (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RARG Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function. Homodimer. Heterodimer with a RXR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Forms a complex with PUS1 and the SRA1 RNA in the nucleus. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor; DNA binding protein
Cellular Component: nucleoplasm; transcription factor complex; integral to membrane; nucleolus; nucleus
Molecular Function: retinoid X receptor binding; protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; retinoic acid receptor activity; transcription factor activity
Biological Process: retinoic acid receptor signaling pathway; transcription initiation from RNA polymerase II promoter; response to retinoic acid; regulation of myelination; positive regulation of apoptosis; embryonic eye morphogenesis; multicellular organism growth; negative regulation of chondrocyte differentiation; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription from RNA polymerase II promoter; embryonic hindlimb morphogenesis; anterior/posterior pattern formation; negative regulation of cell proliferation; positive regulation of programmed cell death; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; gene expression; regulation of cell size
Reference #:  P13631 (UniProtKB)
Alt. Names/Synonyms: NR1B3; Nuclear receptor subfamily 1 group B member 3; RAR-gamma; RARC; RARG; Retinoic acid receptor gamma; retinoic acid receptor, gamma
Gene Symbols: RARG
Molecular weight: 50,342 Da
Basal Isoelectric point: 7.44  Predict pI for various phosphorylation states
CST Pathways:  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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RARG

Protein Structure Not Found.


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Sites Implicated In
transcription, induced: S77‑p, S79‑p
activity, induced: S77‑p, S79‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 R34 FAFPGALRGSPPFEM
2 0 S77-p SEEMVPSsPsPPPPP
2 0 S79-p EMVPSsPsPPPPPRV
0 1 T391 TDLRGISTKGAERAI
0 22 K447 EVPGGQGKGGLKSPA
0 1 S452 QGKGGLKSPA_____
  RARG iso2  
- gap
S66-p SEEMVPSsPsPPPPP
S68-p EMVPSsPsPPPPPRV
T380 TDLRGISTKGAERAI
K436 EVPGGQGKGGLKSPA
S441 QGKGGLKSPA_____
  mouse

► Hide Isoforms
 
R34-m1 FAFPGALrGSPPFEM
S77-p SEEMVPSsPsPPPPP
S79-p EMVPSsPsPPPPPRV
T391-p TDLRGIStKGAERAI
K447-ac EAPGGQGkRGQsPQP
S451-p GQGkRGQsPQPDQGP
  RARG iso2  
- gap
S66-p SEEMVPSsPsPPPPP
S68-p EMVPSsPsPPPPPRV
T380 TDLRGISTKGAERAI
K436-ac EAPGGQGkRGQSPQP
S440 GQGkRGQSPQPDQGP
  rat

 
R34 FAFPGALRGSPPFEM
S77 SEEMVPSSPSPPPPP
S79 EMVPSSPSPPPPPRV
T391 TDLRGISTKGAERAI
K447 EAPGSQGKRGQSPQP
S451 SQGKRGQSPQPDQGP
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