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TAB1 (human)

Overview TAB1 May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Activator protein; Motility/polarity/chemotaxis Cellular Component: protein complex; endosome membrane; cytosol Molecular Function: protein binding; enzyme activator activity; kinase activator activity; catalytic activity Biological Process: heart morphogenesis; I-kappaB kinase/NF-kappaB cascade; activation of MAPK activity; in utero embryonic development; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; Toll signaling pathway; toll-like receptor 1 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; transforming growth factor beta receptor signaling pathway; activation of MAPKKK activity; toll-like receptor signaling pathway; innate immune response; JNK cascade; toll-like receptor 4 signaling pathway; lung development Reference #:  Q15750 (UniProtKB) Alt. Names/Synonyms: 3'-Tab1; MAP3K7IP1; MGC57664; mitogen-activated protein kinase kinase kinase 7 interacting protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TAB1; TAK1-binding protein 1; TGF-beta activated kinase 1/MAP3K7 binding protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; TGF-beta-activated kinase 1-binding protein 1; transforming growth factor beta-activated kinase-binding protein 1 Gene Symbols: TAB1 Molecular weight: 54,644 Da Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states CST Pathways:  Inhibition of Apoptosis  |  NF-kB Signaling  |  Signaling Pathways Activating p38 MAPK  |  Toll-like Receptors Pathway  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TAB1 2J4O - A=1-401 (human) 2POM - A=1-370 (human) 2POP - A/C=1-370 (human) 2YDS - T=392-398 (human) 2YIY - A=468-497 (human) 4AY6 - H/F/G/E=389-401 (human) 4GS6 - A=468-504 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2J4O 2POM 2POP 2YDS 2YIY 4AY6 4GS6  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
inhibition: S423‑p, T431‑p phosphorylation: S423‑p, T431‑p, S438‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	10		S7-p	_MAAQRRsLLQsEQQ
0	3		S11-p	QRRsLLQsEQQPsWT
0	4		S16-p	LQsEQQPsWTDDLPL
0	2		K150-u	QLPPQYQkILERLKT
0	1		Y179-p	VLLNNKLyVANVGtN
0	1		T185-p	LyVANVGtNRALLCK
0	1		S219	EDELFRLSQLGLDAG
0	7		K227-u	QLGLDAGkIKQVGII
0	1		K264-u	LLSAAKSkPIIAEPE
0	1		S378-p	EMSQPTPsPAPAAGG
1	1		S395-g	YPVSVPYsSAQSTSK
0	1		S396	PVSVPYsSAQSTSKT
7	0		S423-p	QMVNGAHsASTLDEA
5	1		T431-p	ASTLDEAtPTLTNQs
6	0		S438-p	tPTLTNQsPTLTLQS
1	0		S452-p	STNTHTQssSSssDG
1	0		S453-p	TNTHTQssSSssDGG
1	0		S456-p	HTQssSSssDGGLFR
1	0		S457-p	TQssSSssDGGLFRS
0	17		Y481-p	EDGRVEPyVDFAEFy
0	1		Y488-p	yVDFAEFyRLWSVDH

	mouse
S7-p	_MAAQRRsLLQsEQQ
S11-p	QRRsLLQsEQQPsWT
S16-p	LQsEQQPsWTDDLPL
K150	QLPPQYQKILERLKA
Y179	VLLNSKLYVANVGTN
T185	LYVANVGTNRALLCK
S219	EDELFRLSQLGLDAG
K227	QLGLDAGKIKQMGVI
K264	LLSAAKSKPIIAEPE
T378	EMSQPTPTPAPGGRV
S393-g	YPVSVPYssAQSTSK
S394-g	PVSVPYssAQSTSKT
S421	QMVNGSHSASTLDEA
T429	ASTLDEATPTLTNQS
S436	TPTLTNQSPTLTLQS
S450	STNTHTQSSSSSSDG
S451	TNTHTQSSSSSSDGG
S454	HTQSSSSSSDGGLFR
S455	TQSSSSSSDGGLFRS
Y479	EDGRVEPYVDFAEFY
Y486	YVDFAEFYRLWSVDH

	rat
S7	_MAAQRRSLLQSEQQ
S11	QRRSLLQSEQQPSWT
S16	LQSEQQPSWTDDLPL
K150	QLLPQYQKILERLKA
Y179	VLLNNKLYVANVGTN
T185	LYVANVGTNRALLCR
S219-p	EDELFRLsQLGLDAG
K227	QLGLDAGKIKQVGVI
K264	LLSTAKSKPIIAEPE
T378	EMSQPTPTPAPGGRV
S393	YPVSVPYSSAQSTSK
S394	PVSVPYSSAQSTSKT
S421	QMVNGSHSASTLDEA
T429	ASTLDEATPTLTNQS
S436	TPTLTNQSPTLTLQS
S450	STNTHTQSSSSSSDG
S451	TNTHTQSSSSSSDGG
S454	HTQSSSSSSDGGLFR
S455	TQSSSSSSDGGLFRS
Y479	EDGRVEPYVDFAEFY
Y486	YVDFAEFYRLWSVDH

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