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Protein Page:
TAB1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TAB1 May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Activator protein
Cellular Component: protein complex; cytoplasm; nucleolus; endosome membrane; cytosol; nucleus
Molecular Function: protein binding; mitogen-activated protein kinase p38 binding; enzyme activator activity; kinase activator activity; protein complex binding; catalytic activity
Biological Process: heart morphogenesis; I-kappaB kinase/NF-kappaB cascade; activation of MAPK activity; in utero embryonic development; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; transforming growth factor beta receptor signaling pathway; activation of MAPKKK activity; toll-like receptor signaling pathway; innate immune response; JNK cascade; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway; lung development
Reference #:  Q15750 (UniProtKB)
Alt. Names/Synonyms: 3'-Tab1; MAP3K7IP1; MGC57664; mitogen-activated protein kinase kinase kinase 7 interacting protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TAB1; TAK1-binding protein 1; TGF-beta activated kinase 1/MAP3K7 binding protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; TGF-beta-activated kinase 1-binding protein 1; transforming growth factor beta-activated kinase-binding protein 1
Gene Symbols: TAB1
Molecular weight: 54,644 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
CST Pathways:  Inhibition of Apoptosis  |  NF-kB Signaling  |  Regulation of P38 MAPKs  |  Toll-Like Receptor Signaling  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TAB1

Protein Structure Not Found.


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Sites Implicated In
activity, inhibited: S423‑p, T431‑p
phosphorylation: S423‑p, T431‑p, S438‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 10 S7-p _MAAQRRsLLQsEQQ
0 3 S11-p QRRsLLQsEQQPsWT
0 4 S16-p LQsEQQPsWTDDLPL
0 2 K150-u QLPPQYQkILERLKT
0 1 Y179-p VLLNNKLyVANVGtN
0 1 T185-p LyVANVGtNRALLCK
0 7 K227-u QLGLDAGkIKQVGII
0 2 S378-p EMSQPTPsPAPAAGG
1 1 S395-gl YPVSVPYsSAQSTSK
0 1 S396 PVSVPYsSAQSTSKT
7 0 S423-p QMVNGAHsASTLDEA
6 1 T431-p ASTLDEAtPTLTNQs
7 0 S438-p tPTLTNQsPTLTLQS
1 0 S452-p STNTHTQssSSssDG
1 0 S453-p TNTHTQssSSssDGG
1 0 S456-p HTQssSSssDGGLFR
1 0 S457-p TQssSSssDGGLFRS
0 17 Y481-p EDGRVEPyVDFAEFY
  mouse

 
S7-p _MAAQRRsLLQsEQQ
S11-p QRRsLLQsEQQPsWT
S16-p LQsEQQPsWTDDLPL
K150 QLPPQYQKILERLKA
Y179 VLLNSKLYVANVGTN
T185 LYVANVGTNRALLCK
K227 QLGLDAGKIKQMGVI
T378 EMSQPTPTPAPGGRV
S393-gl YPVSVPYssAQSTSK
S394-gl PVSVPYssAQSTSKT
S421 QMVNGSHSASTLDEA
T429 ASTLDEATPTLTNQS
S436 TPTLTNQSPTLTLQS
S450 STNTHTQSSSSSSDG
S451 TNTHTQSSSSSSDGG
S454 HTQSSSSSSDGGLFR
S455 TQSSSSSSDGGLFRS
Y479 EDGRVEPYVDFAEFY
  rat

 
S7 _MAAQRRSLLQSEQQ
S11 QRRSLLQSEQQPSWT
S16 LQSEQQPSWTDDLPL
K150 QLLPQYQKILERLKA
Y179 VLLNNKLYVANVGTN
T185 LYVANVGTNRALLCR
K227 QLGLDAGKIKQVGVI
T378 EMSQPTPTPAPGGRV
S393 YPVSVPYSSAQSTSK
S394 PVSVPYSSAQSTSKT
S421 QMVNGSHSASTLDEA
T429 ASTLDEATPTLTNQS
S436 TPTLTNQSPTLTLQS
S450 STNTHTQSSSSSSDG
S451 TNTHTQSSSSSSDGG
S454 HTQSSSSSSDGGLFR
S455 TQSSSSSSDGGLFRS
Y479 EDGRVEPYVDFAEFY
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