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CDX2 (human)

Overview CDX2 Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Belongs to the Caudal homeobox family. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor Cellular Component: condensed nuclear chromosome; transcriptional repressor complex Molecular Function: transcription corepressor activity; transcription factor activity Biological Process: anterior/posterior pattern formation; establishment and/or maintenance of epithelial cell polarity; transcription from RNA polymerase II promoter; blood vessel development; organ morphogenesis; somatic stem cell maintenance; endosome to lysosome transport; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell differentiation; trophectodermal cell differentiation Reference #:  Q99626 (UniProtKB) Alt. Names/Synonyms: caudal type homeo box transcription factor 2; caudal type homeobox 2; caudal type homeobox transcription factor 2; Caudal-type homeobox protein 2; CDX-3; CDX2; CDX3; Homeobox protein CDX-2 Gene Symbols: CDX2 Molecular weight: 33,520 Da Basal Isoelectric point: 9.65  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CDX2

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	Sites Implicated In
protein degradation: S283‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
3	0		S60	ANLDSAQSPGPSWPA
0	1		S226-p	LAATLGLsERQVKIW
0	2		S277-p	PQPGPLRsVPEPLsP
1	1		S283-p	RsVPEPLsPVSSLQA
0	1		S286	PEPLsPVSSLQASVP
0	1		S287	EPLsPVSSLQASVPG
0	1		P309	PTGGVLNPtVtQ___
0	2		T310-p	TGGVLNPtVtQ____
0	1		T312-p	GVLNPtVtQ______

	mouse
S60-p	ANLDSAQsPGPSWPT
S225	LAATLGLSERQVKIW
S275	PQPGALRSVPEPLSP
S281	RSVPEPLSPVTSLQG
T284	PEPLSPVTSLQGSVP
S285	EPLSPVTSLQGSVPG
S307	PAGGVLNSTVTQ___
T308	AGGVLNSTVTQ____
T310	GVLNSTVTQ______

	rat
S60	ANLDSAQSPGPSWPT
S225	LAATLGLSERQVKIW
S274-p	PQSGALRsVPEPLsP
S280-p	RsVPEPLsPVtsLQG
T283-p	PEPLsPVtsLQGSVP
S284-p	EPLsPVtsLQGSVPG
S306-p	PAGGVLNstVTQ___
T307-p	AGGVLNstVTQ____
T309	GVLNstVTQ______

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