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Protein Page:
CDX2 (human)

Overview
CDX2 Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Belongs to the Caudal homeobox family. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Chromosomal Location of Human Ortholog: 13q12.3
Cellular Component: condensed nuclear chromosome; transcriptional repressor complex; nucleolus; nucleus
Molecular Function: double-stranded DNA binding; transcription corepressor activity; transcription factor activity
Biological Process: anterior/posterior pattern formation; transcription from RNA polymerase II promoter; establishment and/or maintenance of epithelial cell polarity; blood vessel development; organ morphogenesis; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; positive regulation of cell proliferation; endosome to lysosome transport; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell differentiation; trophectodermal cell differentiation
Reference #:  Q99626 (UniProtKB)
Alt. Names/Synonyms: caudal type homeo box transcription factor 2; caudal type homeobox 2; caudal type homeobox transcription factor 2; Caudal-type homeobox protein 2; CDX-3; CDX2; CDX3; Homeobox protein CDX-2
Gene Symbols: CDX2
Molecular weight: 33,520 Da
Basal Isoelectric point: 9.65  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CDX2

Protein Structure Not Found.


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Sites Implicated In
protein degradation: S283‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S4-p ____MYVsYLLDKDV
3 0 S60 ANLDSAQSPGPSWPA
0 1 S226-p LAATLGLsERQVKIW
0 2 S277-p PQPGPLRsVPEPLsP
1 1 S283-p RsVPEPLsPVSSLQA
0 1 S286 PEPLsPVSSLQAsVP
0 1 S287 EPLsPVSSLQAsVPG
0 1 S291-p PVSSLQAsVPGsVPG
0 1 S295-p LQAsVPGsVPGVLGP
0 1 P309 PTGGVLNPtVtQ___
0 2 T310-p TGGVLNPtVtQ____
0 1 T312-p GVLNPtVtQ______
  mouse

 
S4 ____MYVSYLLDKDV
S60-p ANLDSAQsPGPSWPT
S225 LAATLGLSERQVKIW
S275 PQPGALRSVPEPLSP
S281 RSVPEPLSPVTSLQG
T284 PEPLSPVTSLQGSVP
S285 EPLSPVTSLQGSVPG
S289 PVTSLQGSVPGSVPG
S293 LQGSVPGSVPGVLGP
S307 PAGGVLNSTVTQ___
T308 AGGVLNSTVTQ____
T310 GVLNSTVTQ______
  rat

 
S4 ____MYVSYLLDKDV
S60 ANLDSAQSPGPSWPT
S225 LAATLGLSERQVKIW
S274-p PQSGALRsVPEPLsP
S280-p RsVPEPLsPVtsLQG
T283-p PEPLsPVtsLQGSVP
S284-p EPLsPVtsLQGSVPG
S288 PVtsLQGSVPGSVPG
S292 LQGSVPGSVPGVLGP
S306-p PAGGVLNstVTQ___
T307-p AGGVLNstVTQ____
T309 GVLNstVTQ______
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