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GATA6 (human)

Overview GATA6 Transcriptional activator that regulates SEMA3C and PLXNA2. Thought to be important for regulating terminal differentiation and/or proliferation. Interacts with LMCD1. Expressed in heart, gut and gut-derived tissues. 2 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB. Protein type: Transcription factor; Motility/polarity/chemotaxis Cellular Component: nucleoplasm; transcription factor complex; nucleus Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; zinc ion binding; double-stranded DNA binding; chromatin binding; transcription factor binding; protein kinase binding; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; endodermal cell fate determination; response to cAMP; apoptosis; positive regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; cardiac muscle cell differentiation; phospholipid metabolic process; positive regulation of BMP signaling pathway; positive regulation of cardiac muscle cell proliferation; response to drug; organ formation; in utero embryonic development; male gonad development; liver development; odontogenesis of dentine-containing teeth; negative regulation of transforming growth factor-beta1 production; negative regulation of transforming growth factor-beta2 production; positive regulation of angiogenesis; response to estrogen stimulus; positive regulation of cardioblast differentiation; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; blood coagulation; negative regulation of transcription, DNA-dependent; tube morphogenesis; negative regulation of apoptosis Reference #:  Q92908 (UniProtKB) Alt. Names/Synonyms: GATA binding protein 6; GATA-binding factor 6; GATA-binding protein 6; GATA6; Transcription factor GATA-6 Gene Symbols: GATA6 Molecular weight: 60,033 Da Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below GATA6

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	Sites Implicated In
cell growth, altered: S266‑p transcription, altered: S266‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	5		T34-p	FPAREPStPPsPISS
0	6		S37-p	REPStPPsPISSSSS
0	1		Y188-p	AAASSPVyVPTTRVG
1	4		S266-p	VSARFPYsPsPPMAN
0	2		S268-p	ARFPYsPsPPMANGA
1	1		Y282-p	AAREPGGyAAAGSGG
0	1		S377-p	LPVPRGPsADLLEDL
0	1		S436-p	KPQKRVPssRRLGLS
0	1		S437-p	PQKRVPssRRLGLSC
0	1		T515	SNNSIPMTPTSTSSN
0	1		S523-p	PTSTSSNsDDCSKNT
0	1		T530	sDDCSKNTSPTTQPT
0	1		S531	DDCSKNTSPTTQPTA
0	1		S558	ESTNPENSELKYSGQ

	mouse
S34-p	FPAREPSsPLsPISS
S37-p	REPSsPLsPISSSSS
Y188	AAASSPVYVPTTRVG
S264	ASARFPYSPSPPMAN
S266	ARFPYSPSPPMANGA
Y280	AARDPGGYVAAGGTG
S371	LPVPRGPSTDLLEDL
S430	KPQKRVPSSRRLGLS
S431	PQKRVPSSRRLGLSC
T509-p	SSGSVPMtPTSSSSN
S517	PTSSSSNSDDCTKNt
T524-p	SDDCTKNtsPSTQAT
S525-p	DDCTKNtsPSTQATT
S552-p	ENANPENsDLKYSGQ

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