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Protein Page:
GATA6 (human)

Overview
GATA6 Transcriptional activator that regulates SEMA3C and PLXNA2. Thought to be important for regulating terminal differentiation and/or proliferation. Interacts with LMCD1. Expressed in heart, gut and gut-derived tissues. 2 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 18q11.1-q11.2
Cellular Component: nucleoplasm; transcription factor complex; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; zinc ion binding; chromatin binding; transcription factor activity; transcription factor binding; protein kinase binding
Biological Process: response to drug; transcription from RNA polymerase II promoter; cardiac muscle hypertrophy; endodermal cell fate determination; organ formation; in utero embryonic development; male gonad development; negative regulation of transcription from RNA polymerase II promoter; liver development; cardiac muscle cell differentiation; negative regulation of transforming growth factor-beta1 production; negative regulation of transforming growth factor-beta2 production; positive regulation of angiogenesis; response to estrogen stimulus; phospholipid metabolic process; positive regulation of cardioblast differentiation; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; tube morphogenesis; negative regulation of transcription, DNA-dependent; blood coagulation; negative regulation of apoptosis; positive regulation of cardiac muscle cell proliferation
Disease: Atrial Septal Defect 9; Conotruncal Heart Malformations; Heart Defects, Congenital, And Other Congenital Anomalies; Atrioventricular Septal Defect 5; Tetralogy Of Fallot
Reference #:  Q92908 (UniProtKB)
Alt. Names/Synonyms: GATA binding protein 6; GATA-binding factor 6; GATA-binding protein 6; GATA6; Transcription factor GATA-6
Gene Symbols: GATA6
Molecular weight: 60,033 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GATA6

Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: S266‑p
transcription, induced: S266‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 5 T34-p FPAREPStPPsPIsS
0 6 S37-p REPStPPsPIsSSSS
0 1 S40-p StPPsPIsSSSSSCS
0 1 Y188-p AAASSPVyVPTTRVG
1 6 S266-p VSARFPYsPsPPMAN
0 4 S268-p ARFPYsPsPPMANGA
1 1 Y282-p AAREPGGyAAAGSGG
0 1 S377-p LPVPRGPsADLLEDL
1 2 S436-p KPQKRVPssRRLGLS
0 2 S437-p PQKRVPssRRLGLSC
0 1 T515 SNNSIPMTPTSTSSN
0 1 S523-p PTSTSSNsDDCSKNT
0 1 T530 sDDCSKNTSPTtQPT
0 1 S531 DDCSKNTSPTtQPTA
0 2 T534-p SKNTSPTtQPTASGA
0 1 S558 ESTNPENSELKYSGQ
  GATA6 iso2  
- gap
- gap
- gap
Y42 AAASSPVYVPTTRVG
S120 VSARFPYSPSPPMAN
S122 ARFPYSPSPPMANGA
Y136 AAREPGGYAAAGSGG
S231 LPVPRGPSADLLEDL
S290-p KPQKRVPsSRRLGLS
S291 PQKRVPsSRRLGLSC
T369 SNNSIPMTPTSTSSN
S377 PTSTSSNSDDCSKNT
T384 SDDCSKNTSPTTQPT
S385 DDCSKNTSPTTQPTA
T388 SKNTSPTTQPTASGA
S412 ESTNPENSELKYSGQ
  mouse

 
S34-p FPAREPSsPLsPISS
S37-p REPSsPLsPISSSSS
S40 SsPLsPISSSSSSCS
Y188 AAASSPVYVPTTRVG
S264 ASARFPYSPSPPMAN
S266 ARFPYSPSPPMANGA
Y280 AARDPGGYVAAGGTG
S371 LPVPRGPSTDLLEDL
S430 KPQKRVPSSRRLGLS
S431 PQKRVPSSRRLGLSC
T509-p SSGSVPMtPTSSSSN
S517 PTSSSSNSDDCTKNt
T524-p SDDCTKNtsPSTQAT
S525-p DDCTKNtsPSTQATT
T528 TKNtsPSTQATTSGV
S552-p ENANPENsDLKYSGQ
  rat

 
S34 FPAREPSSPLSPISS
S37 REPSSPLSPISSSSS
S40 SSPLSPISSSSSSCS
Y188 AAASSPVYVPTTRVG
S264 ASARFPYSPsPPMAN
S266-p ARFPYSPsPPMANGA
Y280 AARDPGGYVAAGGAG
S371 LPVPRGPSADLLEDL
S430 KPQKRVPSSRRLGLS
S431 PQKRVPSSRRLGLSC
T507 GNSSVPMTPTSSSSN
S515 PTSSSSNSDDCTKNT
T522 SDDCTKNTSPPTQST
S523 DDCTKNTSPPTQSTA
T526 TKNTSPPTQSTASGV
S550 ESANPENSDLKYSGQ
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