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Protein Page:
GATA6 (human)

Overview
GATA6 Transcriptional activator that regulates SEMA3C and PLXNA2. Thought to be important for regulating terminal differentiation and/or proliferation. Interacts with LMCD1. Expressed in heart, gut and gut-derived tissues. 2 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Transcription factor
Cellular Component: nucleoplasm; transcription factor complex; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; zinc ion binding; chromatin binding; protein kinase binding; transcription factor binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; cardiac muscle hypertrophy; response to drug; endodermal cell fate determination; organ formation; in utero embryonic development; male gonad development; negative regulation of transcription from RNA polymerase II promoter; liver development; cardiac muscle cell differentiation; negative regulation of transforming growth factor-beta1 production; negative regulation of transforming growth factor-beta2 production; positive regulation of angiogenesis; response to estrogen stimulus; phospholipid metabolic process; positive regulation of cardioblast differentiation; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; tube morphogenesis; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis; positive regulation of cardiac muscle cell proliferation
Reference #:  Q92908 (UniProtKB)
Alt. Names/Synonyms: GATA binding protein 6; GATA-binding factor 6; GATA-binding protein 6; GATA6; Transcription factor GATA-6
Gene Symbols: GATA6
Molecular weight: 60,033 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GATA6

Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: S266‑p
transcription, induced: S266‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 T34-p FPAREPStPPsPISS
0 6 S37-p REPStPPsPISSSSS
0 1 Y188-p AAASSPVyVPTTRVG
1 5 S266-p VSARFPYsPsPPMAN
0 3 S268-p ARFPYsPsPPMANGA
1 1 Y282-p AAREPGGyAAAGSGG
0 1 S377-p LPVPRGPsADLLEDL
0 2 S436-p KPQKRVPssRRLGLS
0 2 S437-p PQKRVPssRRLGLSC
0 1 T515 SNNSIPMTPTSTSSN
0 1 S523-p PTSTSSNsDDCSKNT
0 1 T530 sDDCSKNTSPTtQPT
0 1 S531 DDCSKNTSPTtQPTA
0 2 T534-p SKNTSPTtQPTASGA
0 1 S558 ESTNPENSELKYSGQ
  mouse

 
S34-p FPAREPSsPLsPISS
S37-p REPSsPLsPISSSSS
Y188 AAASSPVYVPTTRVG
S264 ASARFPYSPSPPMAN
S266 ARFPYSPSPPMANGA
Y280 AARDPGGYVAAGGTG
S371 LPVPRGPSTDLLEDL
S430 KPQKRVPSSRRLGLS
S431 PQKRVPSSRRLGLSC
T509-p SSGSVPMtPTSSSSN
S517 PTSSSSNSDDCTKNt
T524-p SDDCTKNtsPSTQAT
S525-p DDCTKNtsPSTQATT
T528 TKNtsPSTQATTSGV
S552-p ENANPENsDLKYSGQ
  rat

 
S34 FPAREPSSPLSPISS
S37 REPSSPLSPISSSSS
Y188 AAASSPVYVPTTRVG
S264 ASARFPYSPsPPMAN
S266-p ARFPYSPsPPMANGA
Y280 AARDPGGYVAAGGAG
S371 LPVPRGPSADLLEDL
S430 KPQKRVPSSRRLGLS
S431 PQKRVPSSRRLGLSC
T507 GNSSVPMTPTSSSSN
S515 PTSSSSNSDDCTKNT
T522 SDDCTKNTSPPTQST
S523 DDCTKNTSPPTQSTA
T526 TKNTSPPTQSTASGV
S550 ESANPENSDLKYSGQ
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