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Protein Page:
GATA6 (human)

Overview
GATA6 Transcriptional activator that regulates SEMA3C and PLXNA2. Thought to be important for regulating terminal differentiation and/or proliferation. Interacts with LMCD1. Expressed in heart, gut and gut-derived tissues. 2 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Transcription factor
Cellular Component: nucleoplasm; transcription factor complex; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; zinc ion binding; chromatin binding; transcription factor binding; transcription factor activity; protein kinase binding
Biological Process: transcription from RNA polymerase II promoter; response to drug; cardiac muscle hypertrophy; organ formation; endodermal cell fate determination; in utero embryonic development; male gonad development; negative regulation of transcription from RNA polymerase II promoter; liver development; cardiac muscle cell differentiation; negative regulation of transforming growth factor-beta1 production; negative regulation of transforming growth factor-beta2 production; positive regulation of angiogenesis; response to estrogen stimulus; phospholipid metabolic process; positive regulation of cardioblast differentiation; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; blood coagulation; negative regulation of transcription, DNA-dependent; tube morphogenesis; positive regulation of cardiac muscle cell proliferation; negative regulation of apoptosis
Reference #:  Q92908 (UniProtKB)
Alt. Names/Synonyms: GATA binding protein 6; GATA-binding factor 6; GATA-binding protein 6; GATA6; Transcription factor GATA-6
Gene Symbols: GATA6
Molecular weight: 60,033 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GATA6

Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: S266‑p
transcription, induced: S266‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 T34-p FPAREPStPPsPISS
0 6 S37-p REPStPPsPISSSSS
0 1 Y188-p AAASSPVyVPTTRVG
1 5 S266-p VSARFPYsPsPPMAN
0 3 S268-p ARFPYsPsPPMANGA
1 1 Y282-p AAREPGGyAAAGSGG
0 1 S377-p LPVPRGPsADLLEDL
0 2 S436-p KPQKRVPssRRLGLS
0 2 S437-p PQKRVPssRRLGLSC
0 1 T515 SNNSIPMTPTSTSSN
0 1 S523-p PTSTSSNsDDCSKNT
0 1 T530 sDDCSKNTSPTtQPT
0 1 S531 DDCSKNTSPTtQPTA
0 1 T534-p SKNTSPTtQPTASGA
0 1 S558 ESTNPENSELKYSGQ
  mouse

 
S34-p FPAREPSsPLsPISS
S37-p REPSsPLsPISSSSS
Y188 AAASSPVYVPTTRVG
S264 ASARFPYSPSPPMAN
S266 ARFPYSPSPPMANGA
Y280 AARDPGGYVAAGGTG
S371 LPVPRGPSTDLLEDL
S430 KPQKRVPSSRRLGLS
S431 PQKRVPSSRRLGLSC
T509-p SSGSVPMtPTSSSSN
S517 PTSSSSNSDDCTKNt
T524-p SDDCTKNtsPSTQAT
S525-p DDCTKNtsPSTQATT
T528 TKNtsPSTQATTSGV
S552-p ENANPENsDLKYSGQ
  rat

 
S34 FPAREPSSPLSPISS
S37 REPSSPLSPISSSSS
Y188 AAASSPVYVPTTRVG
S264 ASARFPYSPSPPMAN
S266 ARFPYSPSPPMANGA
Y280 AARDPGGYVAAGGAG
S371 LPVPRGPSADLLEDL
S430 KPQKRVPSSRRLGLS
S431 PQKRVPSSRRLGLSC
T507 GNSSVPMTPTSSSSN
S515 PTSSSSNSDDCTKNT
T522 SDDCTKNTSPPTQST
S523 DDCTKNTSPPTQSTA
T526 TKNTSPPTQSTASGV
S550 ESANPENSDLKYSGQ
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