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Protein Page:
MAN1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MAN1 Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. Defects in LEMD3 are the cause of Buschke-Ollendorff syndrome (BOS); also known as dermatoosteopoikilosis or disseminated dermatofibrosis with osteopoikilosis or dermatofibrosis lenticularis disseminata with osteopoikilosis or osteopathia condensans disseminata. BOS refers to the association of osteopoikilosis with disseminated connective-tissue nevi. Osteopoikilosis is a skeletal dysplasia characterized by a symmetric but unequal distribution of multiple hyperostotic areas in different parts of the skeleton. Both elastic-type nevi (juvenile elastoma) and collagen-type nevi (dermatofibrosis lenticularis disseminata) have been described in BOS. Skin or bony lesions can be absent in some family members, whereas other relatives may have both. Defects in LEMD3 are a cause of melorheostosis (MEL). Melorheostosis is a rare mesenchymal dysplasia and one of the sclerosing bone disorders. It is caused by a developmental error, with a sclerotomal distribution, frequently involving one limb. It may be asymptomatic, but pain, stiffness with limitation of motion, leg-length discrepancy and limb deformity may occur. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Nuclear envelope; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 12q14
Cellular Component: membrane; integral to membrane; nuclear inner membrane; integral to nuclear inner membrane
Molecular Function: protein binding; DNA binding; nucleotide binding
Biological Process: negative regulation of activin receptor signaling pathway; regulation of cell cycle; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of BMP signaling pathway
Reference #:  Q9Y2U8 (UniProtKB)
Alt. Names/Synonyms: Inner nuclear membrane protein Man1; integral inner nuclear membrane protein; LEM domain containing 3; LEM domain-containing protein 3; LEMD3; MAN1
Gene Symbols: LEMD3
Molecular weight: 99,997 Da
Basal Isoelectric point: 7.32  Predict pI for various phosphorylation states
Select Structure to View Below

MAN1

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S402‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S7-p _MAAAAAsAPQQLsD
0 2 S13-p AsAPQQLsDEELFSQ
0 2 Y24-p LFSQLRRyGLsPGPV
0 8 S27-p QLRRyGLsPGPVtEs
0 1 T32-p GLsPGPVtEsTRPVY
0 1 S34-p sPGPVtEsTRPVYLK
0 2 S95-p GMGVRPVsGDLSYLR
0 1 T103-p GDLSYLRtPGGLCRI
0 1 - under review  
0 1 S133 SAAPAAGSKVLLGFs
0 13 S140-p SKVLLGFssDEsDVE
0 31 S141-p KVLLGFssDEsDVEA
0 106 S144-p LGFssDEsDVEAsPR
0 1 S149-p DEsDVEAsPRDQAGG
0 3 S164-p GGRKDRAsLQYRGLK
0 4 S185-p AASEVTNsNsAERRK
0 9 S187-p SEVTNsNsAERRKPH
0 7 T209-p PAGPELQtPPGKDGA
0 1 Y252-p NGSRLVPySCRENys
0 4 Y258-p PySCRENysDsEEED
0 12 S259-p ySCRENysDsEEEDD
0 18 S261-p CRENysDsEEEDDDD
0 3 S280-p RQVLKDDsLSRHRPR
0 1 T289-p SRHRPRRtHsKPLPP
0 3 S291-p HRPRRtHsKPLPPLT
0 2 S309-p AGGRLETsVQGGGGL
0 3 S327-p DRAAAAGsLDRsRNL
0 4 S331-p AAGsLDRsRNLEEAA
0 3 S351-p GGCDQVDssPVPRYR
0 3 S352-p GCDQVDssPVPRYRV
0 3 T365-p RVNAKKLtPLLPPPL
0 1 S381-p DMDSTLDssTGSLLK
0 1 S382-p MDSTLDssTGSLLKT
0 2 S399-p HIGGGAFsVDsPRIY
1 9 S402-p GGAFsVDsPRIYSNS
0 1 Y441-p HTYLKNTyNkPkLsE
0 1 K443-ac YLKNTyNkPkLsEPE
0 1 K445-ac KNTyNkPkLsEPEEE
0 2 S447-p TyNkPkLsEPEEELL
0 6 K458-ub EELLQQFkREEVsPT
0 1 S463-p QFkREEVsPTGSFSA
0 1 K524-ub GKIQESEkTLMMNTL
0 1 T530 EkTLMMNTLYKLHDR
0 1 Y532 TLMMNTLYKLHDRLA
0 1 T630-p RFRRAFVtVtHRLLL
0 1 T632-p RRAFVtVtHRLLLLC
0 3 Y651-p MVCVVLRyMKYRWTK
0 1 S679-p KIIDVLRsHNEACQE
0 3 S777-p FHLDRRNsPPNsLtP
0 1 S781-p RRNsPPNsLtPCLKI
0 2 T783-p NsPPNsLtPCLKIRN
0 2 K827-ub IVHIAVDkNSREGCV
0 1 S840-p CVYVKCLsPEyAGKA
0 1 Y843-p VKCLsPEyAGKAFKA
0 5 T883-p PQALTSNtPLKPsNK
0 2 S888-p SNtPLKPsNKHMNSM
0 1 S896-p NKHMNSMsHLRLRTG
0 11 S907-p LRTGLTNsQGSs___
0 1 S911-p LTNsQGSs_______
  mouse

 
A8 MAAATAAAAPQQLSD
S14 AAAPQQLSDEELFSQ
Y25 LFSQLRRYGLSPGPV
S28 QLRRYGLSPGPVTES
T33 GLSPGPVTESTRPVY
S35 SPGPVTESTRPVYLK
S90 AMGGRPGSGDLAYLR
S98 GDLAYLRSPAGLGRL
S118-p ESPVAGGsGGAAAVP
S129-p AAVPAAGsKVLLGFs
S136-p sKVLLGFssDEsDVE
S137-p KVLLGFssDEsDVEA
S140-p LGFssDEsDVEASPR
S145 DEsDVEASPREQAGG
A164 GARRDRAALQYRGLR
G185 AAGEVTGGHPGERRK
P187 GEVTGGHPGERRKPH
P209 PAGPEPQPPAAGSDG
Y253 NGSRLLPYSSCREHy
Y260-p YSSCREHysDsEEEE
S261-p SSCREHysDsEEEEE
S263-p CREHysDsEEEEEEG
S287 RQVLKDDSLARHRPR
S296 ARHRPRRSHSKPFSA
S298 HRPRRSHSKPFSALT
S316 GGSRQETSVQGGGAL
S334 DRAAAAGSLDRSRNL
S338 AAGSLDRSRNLEEAA
S363 CGCDPVDSIPRYRAG
- gap
A375 RAGAKKLAPLLSPPS
S391 DGDSTLESPTGPLLK
P392 GDSTLESPTGPLLKT
G409 HIGGGAFGVDSPGLY
S412 GGAFGVDSPGLYANS
Y452 HTYLKTAYGKPKLCE
K454 YLKTAYGKPKLCEPE
K456 KTAYGKPKLCEPEEE
C458 AYGKPKLCEPEEELL
K469 EELLQQFKREEVSPT
S474 QFKREEVSPTGSFSA
K534 GKIQESEKNLLMStL
T540-p EKNLLMStLyKLHDR
Y542-p NLLMStLyKLHDRLA
T640 RFRRAFITVTHRLLL
T642 RRAFITVTHRLLLLC
Y661 LVCVALRYMRYRWTK
S689 KIIDVLRSHNEACQE
S787 FHLDRRNSPPNSLTP
S791 RRNSPPNSLTPCLKI
T793 NSPPNSLTPCLKIRN
R837 IVHIAVDRNSREGCV
S850 CVYVKCLSPEYAGKA
Y853 VKCLSPEYAGKAFKA
T893 PQALTCNTPLKPANK
A898 CNTPLKPANKHMNSL
S906 NKHMNSLSHLRLRTG
S917 LRTGLANSQGSS___
S921 LANSQGSS_______
  rat

 
S10 AAAATAASAPQQLSD
S16 ASAPQQLSDEELFSQ
Y27 LFSQLRRYGLSPGPV
S30 QLRRYGLSPGPVTES
T35 GLSPGPVTESTRPVY
S37 SPGPVTESTRPVYLK
S95 GMGVRPGSGDFAYLR
T103 GDFAYLRTPAGLGRL
S122 PESPAGGSGVAAAVP
S133 AAVPAAGSKVLLGFs
S140-p SKVLLGFssDEsDVE
S141-p KVLLGFssDEsDVEA
S144-p LGFssDEsDVEASPR
S149 DEsDVEASPREQAGG
A165 GARRDRAALQYRGLK
G186 VAGEATSGNSAERRK
S188 GEATSGNSAERRKPH
L210 PVGPEPQLPSGSDGA
Y253 NGSRLLPYSCREHYs
Y259 PYSCREHYsDsEEED
S260-p YSCREHYsDsEEEDD
S262-p CREHYsDsEEEDDGG
S282 RQVLKDDSLSRHRPR
S291 SRHRPRRSHSKPFSA
S293 HRPRRSHSKPFSALT
S311 GGSRQETSVQGGGGL
S329 DRAAAAGSLDRSRNL
S333 AAGSLDRSRNLEEAA
S357 GGCDQVDSIPRYRAG
- gap
A369 RAGAKKLAPLLSPPS
S385 DVDSTLESPTGPLKT
P386 VDSTLESPTGPLKTN
G403 IGGGGAFGVDSPSLY
S406 GGAFGVDSPSLYANS
Y445 HTYLKNAYSKPKLCE
K447 YLKNAYSKPKLCEPE
K449 KNAYSKPKLCEPEEE
C451 AYSKPKLCEPEEELL
K462 EELLQQFKREEVSPT
S467 QFKREEVSPTGSFSA
K527 GKIQASEKNLMMSTL
T533 EKNLMMSTLYKLHDR
Y535 NLMMSTLYKLHDRLA
T633 RFRRAFITVTHRLLL
T635 RRAFITVTHRLLLLC
Y654 LVCAVLRYMRYRWTK
S682 KIIDVLRSHNEACQE
S780 FHLDRRNSPPNSLTP
S784 RRNSPPNSLTPCLKI
T786 NSPPNSLTPCLKIRN
R830 IVHIAVDRNSREGCV
S843 CVYVKCLSPGHAGKA
H846 VKCLSPGHAGKAFKA
T886 PQALTCSTPLKPSDK
S891 CSTPLKPSDKHMNSM
S899 DKHMNSMSHLRLRTG
S910 LRTGLANSQGSS___
S914 LANSQGSS_______
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