Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine- specific kinase. Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A. Belongs to the S-100 family. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding protein
Cellular Component: extrinsic to plasma membrane; endoplasmic reticulum; lipid raft
Molecular Function: protein binding; protein homodimerization activity; calcium ion binding
Biological Process: positive regulation of focal adhesion formation; positive regulation of stress fiber formation; protein heterotetramerization; positive regulation of Rac GTPase activity; positive regulation of binding; lipid raft formation; membrane budding
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.