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TESK1 (human)

Overview TESK1 a TKL kinase of the LISK fanily. Its testicular germ cell-specific expression and developmental pattern of expression in the mouse suggests that this kinase plays an important role at and after the meiotic phase of spermatogenesis. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; Protein kinase, TKL; EC 2.7.12.1; Protein kinase, Ser/Thr (non-receptor); TKL group; LISK family; TESK subfamily Cellular Component: cytosol Molecular Function: protein serine/threonine kinase activity; protein binding; metal ion binding; protein-tyrosine kinase activity; protein serine/threonine/tyrosine kinase activity; ATP binding Biological Process: spermatogenesis Reference #:  Q15569 (UniProtKB) Alt. Names/Synonyms: Dual specificity testis-specific protein kinase 1; TESK1; Testicular protein kinase 1; testis-specific kinase 1 Gene Symbols: TESK1 Molecular weight: 67,684 Da Basal Isoelectric point: 8.44  Predict pI for various phosphorylation states CST Pathways:  Regulation of Microtubule Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TESK1

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S69-p	KIGAGFFsEVYKVRH
1	0		S220	EPLAVVGSPYWMAPE
0	1		S342	SVARGGPSATLPRPD
0	2		S353	PRPDPRLSRSRSDLF
0	3		S364	SDLFLPPSPESPPNW
0	1		K391-a	REDLRGGkIkLLDTP
0	1		K393-a	DLRGGkIkLLDTPSk
0	1		K400-a	kLLDTPSkPVLPLVP
0	6		S437-p	TPARRCRsLPSsPEL
0	5		S441-p	RCRsLPSsPELPRRM
0	1		S553-p	ALERTEPsPPPSAPR

	mouse
S64	KIGAGFFSEVYKVRH
S215	EPLAVVGSPYWMAPE
S342-p	SVPRGGPsATLPRPD
S353-p	PRPDPRLsRSRSDLF
S364-p	SDLFLPPsPESPPSW
K391	REDLRGGKIKLLDTP
K393	DLRGGKIKLLDTPCK
K400	KLLDTPCKPATPLPL
S439-p	TPVRRCRsLPSsPEL
S443-p	RCRsLPSsPELPRRM
S554	ALERTEPSPPPSAPR

	rat
S64	KIGAGFFSEVYKVRH
S215-p	EPLAVVGsPYWMAPE
S342	SVPRGGPSATLPRSD
S353	PRSDPRLSRSRSDLF
S364-p	SDLFLPPsPESPPSW
K391	REDLRGGKIKLLDTP
K393	DLRGGKIKLLDTPCK
K400	KLLDTPCKPATPLPL
S439	TPVRRCRSLPSSPEL
S443	RCRSLPSSPELPRRM
S555	ALERTEPSPPPSAPR

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