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Protein Page:
CXCL1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CXCL1 Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. Belongs to the intercrine alpha (chemokine CxC) family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis
Cellular Component: extracellular space; extracellular region
Molecular Function: growth factor activity; chemokine activity; enzyme activator activity; receptor binding
Biological Process: positive regulation of catalytic activity; nervous system development; G-protein coupled receptor protein signaling pathway; cell proliferation; negative regulation of cell proliferation; immune response; inflammatory response; actin cytoskeleton organization and biogenesis; chemotaxis; signal transduction
Reference #:  P09341 (UniProtKB)
Alt. Names/Synonyms: C-X-C motif chemokine 1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); CXCL1; fibroblast secretory protein; FSP; GRO; GRO-alpha(1-73); GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73); GRO1; GRO1 oncogene (melanoma growth stimulating activity, alpha); GRO1 oncogene (melanoma growth-stimulating activity); GROA; Growth-regulated alpha protein; Melanoma growth stimulatory activity; melanoma growth stimulatory activity alpha; MGSA; MGSA alpha; MGSA-a; NAP-3; Neutrophil-activating protein 3; SCYB1
Gene Symbols: CXCL1
Molecular weight: 11,301 Da
Basal Isoelectric point: 10.46  Predict pI for various phosphorylation states
Select Structure to View Below

CXCL1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 N102 KIIEKMLNSDKSN__
0 1 K105 EKMLNSDKSN_____
  mouse

 
K95-ac IIIKKILkSGkSS__
K98-ac KKILkSGkSS_____
  rat

 
K96 KIIQKLLKSDKSS__
K99 QKLLKSDKSS_____
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