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Protein Page:
CDKL5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CDKL5 a protein kinase of the CDKL family. Mutations have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.22; Protein kinase, CMGC; CMGC group; CDKL family
Cellular Component: dendrite cytoplasm; cytoplasm; nucleolus; nucleus
Molecular Function: protein serine/threonine kinase activity; cyclin-dependent protein kinase activity; Rac GTPase binding; kinase activity; ATP binding; protein kinase activity
Biological Process: protein amino acid autophosphorylation; positive regulation of axon extension; regulation of dendrite development; neuron migration; positive regulation of Rac GTPase activity; positive regulation of dendrite morphogenesis; cell cycle; protein amino acid phosphorylation
Reference #:  O76039 (UniProtKB)
Alt. Names/Synonyms: CDKL5; Cyclin-dependent kinase-like 5; ISSX; serine/threonine kinase 9; Serine/threonine-protein kinase 9; STK9
Gene Symbols: CDKL5
Molecular weight: 115,538 Da
Basal Isoelectric point: 9.58  Predict pI for various phosphorylation states
Select Structure to View Below

CDKL5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K2-ac ______MkIPNIGNV
0 2 K12-ac NIGNVMNkFEILGVV
0 1 Y24 GVVGEGAYGVVLKCR
0 1 K33-ac VVLKCRHkETHEIVA
0 1 T35 LKCRHkETHEIVAIK
0 1 Y117 EKVKSYIYQLIKAIH
0 21 Y168-p SEGNNANytEyVATR
1 0 T169-p EGNNANytEyVATRW
1 521 Y171-p NNANytEyVATRWyR
0 2 T174 NytEyVATRWyRSPE
0 1 Y177-p EyVATRWyRSPELLL
0 1 Y188-p ELLLGAPyGKSVDMW
0 1 Y239 SEQMKLFYSNPRFHG
0 24 Y262-p PQSLERRyLGILNSV
0 1 Y286-p KLDPADRyLTEQCLN
0 5 S306-p TQRLLDRsPSRSAKR
0 1 S308 RLLDRsPSRSAKRKP
0 6 Y316 RSAKRKPYHVESSTL
0 1 S341-p ALQSHHRsNsKDIQN
0 1 S343-p QSHHRsNsKDIQNLS
0 2 S377-p NLAGASLsPLHTKTY
0 13 S407-p NNIPHLLsPKEAKSK
0 3 S446-p RSQQNRHsFMESSQS
0 3 Y469 EKQSRHSYIDTIPQS
0 2 S479-p TIPQSSRsPSyRTKA
0 1 Y482-p QSSRsPSyRTKAKsH
0 1 S488-p SyRTKAKsHGALSDS
0 1 S512-p RAQIAEPsTSRYFPS
0 2 S520-p TSRYFPSsCLDLNsP
0 2 S526-p SsCLDLNsPTsPTPt
0 1 S529-p LDLNsPTsPTPtRHS
0 1 T533-p sPTsPTPtRHSDTRT
0 2 S543-p SDTRTLLsPSGRNNR
0 1 S603-p LGYTSPFsSQQRPHR
0 2 Y614 RPHRHSMYVTRDKVR
0 1 T616 HRHSMYVTRDKVRAK
0 1 S646-p ANSLQLLsPQPGEQL
0 1 T658-p EQLPPEMtVARSSVK
0 1 S681-p SFHTRQKsEGGVyHD
0 6 Y686-p QKsEGGVyHDPHSDD
0 5 S691 GVyHDPHSDDGTAPK
0 14 Y704-p PKENRHLyNDPVPRR
0 4 S720-p GSFYRVPsPRPDNsF
0 2 S726-p PsPRPDNsFHENNVS
0 3 S761-p PAFDPWKsPENISHS
0 2 T813-p KSIHSAStPSSRPKE
0 1 T831-p EKISDLQtQsQPLKS
0 1 S833-p ISDLQtQsQPLKSLR
0 1 S855 ASNHPASSDPRFQPL
0 1 T983-p PTLQVRGtDAFsCPT
0 1 S987-p VRGtDAFsCPTQQSG
  mouse

 
K2 ______MKIPNIGNV
K12 NIGNVMNKFEILGVV
Y24-p GVVGEGAyGVVLKCR
K33 VVLKCRHKEtHEIVA
T35-p LKCRHKEtHEIVAIK
Y117 EKVKSYIYQLIKAIH
Y168-p SEGNNANyTEyVAtR
T169 EGNNANyTEyVAtRW
Y171-p NNANyTEyVAtRWYR
T174-p NyTEyVAtRWYRSPE
Y177 EyVAtRWYRSPELLL
Y188 ELLLGAPYGKSVDMW
Y239 SEQMKLFYSNPRFHG
Y262-p PQSLERRyLGILNSV
Y286 KLDPADRYLTEQCLN
S306-p TQRLLDRsPsRSTKR
S308-p RLLDRsPsRSTKRKP
Y316 RSTKRKPYHVESSTL
S341-p ALQTHHRsNsKDIQN
S343-p QTHHRsNsKDIQNLS
S377 NLAGATLSPMHTKTY
S407-p NNIPHLLsPKEAKSK
S446 RSQQNRHSFMESSQS
Y469 EKQSRHSYIDTIPQS
S479 TIPQSSRSPSYRTKA
Y482 QSSRSPSYRTKAKSH
S488 SYRTKAKSHGALSDS
N512 RAQITETNTSRYFPS
S520 TSRYFPSSCLDLNsP
S526-p SSCLDLNsPTSPTPT
S529 LDLNsPTSPTPTRHT
T533 sPTSPTPTRHTDTRT
S543-p TDTRTLLsPSGRNNR
S603 LGYTSPFSSQQRPHR
Y614 RPHRHSMYVTRDKVR
T616 HRHSMYVTRDKVRAK
S646 ANSLQLLSPQPGEQL
T658 EQLPPEMTVARPSVK
S681 SFHTRQKSEGGVYHD
Y686 QKSEGGVYHDPHsDD
S691-p GVYHDPHsDDGTAPK
Y704 PKENRHLYNDPVPRR
S720-p GSFYRVPsPRPDNSF
S726 PsPRPDNSFHENNVS
S761-p PGFDPWKsPENISHA
T813 KAIHSSSTASSRPKE
T831 EKLSDLQTQSQPLKS
S833 LSDLQTQSQPLKSLR
S855-p STNHPASsDPRFQPL
- gap
- gap
  rat

 
K2 ______MKIPNIGNV
K12 NIGNVMNKFEILGVV
Y24 GVVGEGAYGVVLKCR
K33 VVLKCRHKETHEIVA
T35 LKCRHKETHEIVAIK
Y117-p EKVKSYIyQLIKAIH
Y168-p SEGNNANyTEyVAtR
T169 EGNNANyTEyVAtRW
Y171-p NNANyTEyVAtRWYR
T174-p NyTEyVAtRWYRSPE
Y177 EyVAtRWYRSPELLL
Y188 ELLLGAPYGKSVDMW
Y239-p SEQMKLFySNPRFHG
Y262 PQSLERRYLGILNSV
Y286 KLDPADRYLTEQCLN
S306 TQRLLDRSPSRSTKR
S308 RLLDRSPSRSTKRKP
Y316-p RSTKRKPyHVESSTL
S341 ALQTHHRSNSKDIQN
S343 QTHHRSNSKDIQNLS
S377 NLAGATLSPMHTKTY
S407 NNIPHLLSPKEAKSK
S446 RSQQNRHSFMESSQS
Y469-p EKQSRHSyIDTIPQS
S479 TIPQSSRSPSYRTKA
Y482 QSSRSPSYRTKAKSH
S488 SYRTKAKSHGALSDS
N512 RAQITETNTSRYFPS
S520 TSRYFPSSCLDLNSP
S526 SSCLDLNSPTSPTPT
S529 LDLNSPTSPTPTRHT
T533 SPTSPTPTRHTDTRT
S543 TDTRTLLSPSGRNNR
S603 LGYTSPFSSQQRPHR
Y614-p RPHRHSMyVtRDKVR
T616-p HRHSMyVtRDKVRAK
S646 ANSLQLLSPQPGEQL
T658 EQLPPEMTVARPSVK
S681 SFHTRQKSEGGVyHD
Y686-p QKSEGGVyHDPHsDD
S691-p GVyHDPHsDDGTAPK
Y704-p PKENRHLyNDPVPRR
S720 GSFYRVPSPRPDNSF
S726 PSPRPDNSFHENNVS
S761 PGFDPWKSPENISHS
T813 KAIHSSSTASSRPKE
T831 EKLSDLQTQSQPLKS
S833 LSDLQTQSQPLKSLR
S855 STNHPASSDPRFQPL
- gap
- gap
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