a protein kinase of the CDKL family. Mutations have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; EC 126.96.36.199; Kinase, protein; CMGC group; CDKL family
Cellular Component: dendrite cytoplasm; nucleus
Molecular Function: protein serine/threonine kinase activity; cyclin-dependent protein kinase activity; Rac GTPase binding; kinase activity; ATP binding; protein kinase activity
Biological Process: protein amino acid autophosphorylation; positive regulation of axon extension; neuron migration; regulation of dendrite development; positive regulation of Rac GTPase activity; positive regulation of dendrite morphogenesis; protein amino acid phosphorylation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.