Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
CdkL5 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CdkL5 a protein kinase of the CDKL family. Mutations have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; EC 2.7.11.22; Kinase, protein; CMGC group; CDKL family
Cellular Component: dendrite cytoplasm; nucleus
Molecular Function: protein serine/threonine kinase activity; cyclin-dependent protein kinase activity; Rac GTPase binding; kinase activity; ATP binding; protein kinase activity
Biological Process: protein amino acid autophosphorylation; positive regulation of axon extension; neuron migration; regulation of dendrite development; positive regulation of Rac GTPase activity; positive regulation of dendrite morphogenesis; protein amino acid phosphorylation
Reference #:  O76039 (UniProtKB)
Alt. Names/Synonyms: CDKL5; Cyclin-dependent kinase-like 5; ISSX; serine/threonine kinase 9; Serine/threonine-protein kinase 9; STK9
Gene Symbols: CDKL5
Molecular weight: 115,538 Da
Basal Isoelectric point: 9.58  Predict pI for various phosphorylation states
Select Structure to View Below

CdkL5

Protein Structure Not Found.


STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K2-a ______MkIPNIGNV
0 2 K12-a NIGNVMNkFEILGVV
0 1 Y24 GVVGEGAYGVVLKCR
0 2 Y168-p SEGNNANytEyVATR
1 0 T169-p EGNNANytEyVATRW
1 519 Y171-p NNANytEyVATRWyR
0 1 T174 NytEyVATRWyRSPE
0 1 Y177-p EyVATRWyRSPELLL
0 1 Y188-p ELLLGAPyGKSVDMW
0 24 Y262-p PQSLERRyLGILNSV
0 1 Y286-p KLDPADRyLTEQCLN
0 5 S306-p TQRLLDRsPSRSAKR
0 1 S308 RLLDRsPSRSAKRKP
0 1 S341-p ALQSHHRsNsKDIQN
0 1 S343-p QSHHRsNsKDIQNLS
0 1 S377-p NLAGASLsPLHTKTY
0 12 S407-p NNIPHLLsPKEAKSK
0 3 S446-p RSQQNRHsFMESSQS
0 1 S479-p TIPQSSRsPSYRTKA
0 1 S488-p SYRTKAKsHGALSDS
0 1 S512-p RAQIAEPsTSRYFPS
0 2 S520-p TSRYFPSsCLDLNsP
0 2 S526-p SsCLDLNsPTsPTPT
0 1 S529-p LDLNsPTsPTPTRHS
0 2 S543-p SDTRTLLsPSGRNNR
0 1 S646-p ANSLQLLsPQPGEQL
0 2 Y686-p QKSEGGVyHDPHSDD
0 1 S691 GVyHDPHSDDGTAPK
0 4 S720-p GSFYRVPsPRPDNsF
0 2 S726-p PsPRPDNsFHENNVS
0 3 S761-p PAFDPWKsPENISHS
0 2 T813-p KSIHSAStPSSRPKE
  mouse

 
K2 ______MKIPNIGNV
K12 NIGNVMNKFEILGVV
Y24-p GVVGEGAyGVVLKCR
Y168-p SEGNNANyTEyVAtR
T169 EGNNANyTEyVAtRW
Y171-p NNANyTEyVAtRWYR
T174-p NyTEyVAtRWYRSPE
Y177 EyVAtRWYRSPELLL
Y188 ELLLGAPYGKSVDMW
Y262-p PQSLERRyLGILNSV
Y286 KLDPADRYLTEQCLN
S306-p TQRLLDRsPsRSTKR
S308-p RLLDRsPsRSTKRKP
S341-p ALQTHHRsNsKDIQN
S343-p QTHHRsNsKDIQNLS
S377 NLAGATLSPMHTKTY
S407-p NNIPHLLsPKEAKSK
S446 RSQQNRHSFMESSQS
S479 TIPQSSRSPSYRTKA
S488 SYRTKAKSHGALSDS
N512 RAQITETNTSRYFPS
S520 TSRYFPSSCLDLNsP
S526-p SSCLDLNsPTSPTPT
S529 LDLNsPTSPTPTRHT
S543-p TDTRTLLsPSGRNNR
S646 ANSLQLLSPQPGEQL
Y686 QKSEGGVYHDPHsDD
S691-p GVYHDPHsDDGTAPK
S720-p GSFYRVPsPRPDNSF
S726 PsPRPDNSFHENNVS
S761-p PGFDPWKsPENISHA
T813 KAIHSSSTASSRPKE
  rat

 
K2 ______MKIPNIGNV
K12 NIGNVMNKFEILGVV
Y24 GVVGEGAYGVVLKCR
Y168 SEGNNANYTEYVATR
T169 EGNNANYTEYVATRW
Y171 NNANYTEYVATRWYR
T174 NYTEYVATRWYRSPE
Y177 EYVATRWYRSPELLL
Y188 ELLLGAPYGKSVDMW
Y262 PQSLERRYLGILNSV
Y286 KLDPADRYLTEQCLN
S306 TQRLLDRSPSRSTKR
S308 RLLDRSPSRSTKRKP
S341 ALQTHHRSNSKDIQN
S343 QTHHRSNSKDIQNLS
S377 NLAGATLSPMHTKTY
S407 NNIPHLLSPKEAKSK
S446 RSQQNRHSFMESSQS
S479 TIPQSSRSPSYRTKA
S488 SYRTKAKSHGALSDS
N512 RAQITETNTSRYFPS
S520 TSRYFPSSCLDLNSP
S526 SSCLDLNSPTSPTPT
S529 LDLNSPTSPTPTRHT
S543 TDTRTLLSPSGRNNR
S646 ANSLQLLSPQPGEQL
Y686 QKSEGGVYHDPHSDD
S691 GVYHDPHSDDGTAPK
S720 GSFYRVPSPRPDNSF
S726 PSPRPDNSFHENNVS
S761 PGFDPWKSPENISHS
T813 KAIHSSSTASSRPKE
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.