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NFH (human)

Overview NFH Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins. Belongs to the intermediate filament family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Cytoskeletal protein Cellular Component: mitochondrion; axon; neurofilament Biological Process: cell death; nervous system development; neurofilament cytoskeleton organization and biogenesis; microtubule cytoskeleton organization and biogenesis; intermediate filament bundle assembly Reference #:  P12036 (UniProtKB) Alt. Names/Synonyms: 200 kDa neurofilament protein; KIAA0845; NEFH; Neurofilament heavy polypeptide; Neurofilament triplet H protein; neurofilament, heavy polypeptide; neurofilament, heavy polypeptide 200kDa; NF-H; NFH Gene Symbols: NEFH Molecular weight: 112,479 Da Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NFH

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K31-u	LHYALARkGGAGGTR
0	1		S39	GGAGGTRSAAGSSSG
1	0		T53	GFHSWTRTSVSSVsA
1	0		S54	FHSWTRTSVSSVsAs
1	0		S56	SWTRTSVSSVsAsPs
0	2		S59-p	RTSVSSVsAsPsRFR
0	7		S61-p	SVSSVsAsPsRFRGA
0	1		S63-p	SSVsAsPsRFRGAGA
0	1		S72	FRGAGAASSTDSLDT
0	1		T74	GAGAASSTDSLDTLS
0	1		S76	GAASSTDSLDTLSNG
0	1		T79	SSTDSLDTLSNGPEG
0	1		K98	VATSRSEKEQLQALN
0	1		Y111-p	LNDRFAGyIDKVRQL
0	2		S124	QLEAHNRSLEGEAAA
0	36		Y229-p	ALQEECGyLRRHHQE
0	3		K264	AETRDALKCDVTSAL
0	1		K305	DRLSEAAKVNTDAMR
0	61		Y321-p	AQEEITEyRRQLQAR
0	1		S337-p	TELEALKsTKDSLER
0	4		Y385-p	MAAQLREyQDLLNVK
0	2		Y402	LDIEIAAYRKLLEGE
0	11		K404	IEIAAYRKLLEGEEC
0	14		I418	CRIGFGPIPFsLPEG
0	5		S421-p	GFGPIPFsLPEGLPK
0	1		P423	GPIPFsLPEGLPKIP
0	2		K428	sLPEGLPKIPsVSTH
0	2		S431-p	EGLPKIPsVSTHIKV
0	1		S433	LPKIPsVSTHIKVKS
0	1		S440	STHIKVKSEEKIKVV
0	1		K445	VKSEEKIKVVEKSEK
0	4		T501-p	AEGGEEEtKsPPAEE
2	8		S503-p	GGEEEtKsPPAEEAA
1	7		S511-p	PPAEEAAsPEKEAKs
0	1		A516	AAsPEKEAKsPVKEE
0	1		S518-p	sPEKEAKsPVKEEAK
0	9		S526-p	PVKEEAKsPAEAksP
0	1		K531-u	AKsPAEAksPEKEEA
0	18		S532-p	KsPAEAksPEKEEAK
0	13		S540-p	PEKEEAKsPAEVKsP
0	13		S546-p	KsPAEVKsPEKAKsP
0	4		S552-p	KsPEKAKsPAKEEAK
0	7		S560-p	PAKEEAKsPPEAksP
0	1		K565	AKsPPEAKsPEKEEA
0	1		K565-u	AKsPPEAksPEKEEA
0	10		S566-p	KsPPEAksPEKEEAK
0	8		-	gap
0	16		S574-p	PEKEEAKsPAEVKsP
0	14		S580-p	KsPAEVKsPEKAKSP
0	11		S586	KsPEKAKSPAKEEAK
0	1		-	gap
0	9		-	gap
0	9		S594-p	PAKEEAKsPAEAKsP
0	18		S600-p	KsPAEAKsPEKAKsP
0	14		S606-p	KsPEKAKsPVKEEAK
0	10		-	gap
0	12		S614-p	PVKEEAKsPAEAKsP
0	15		S620-p	KsPAEAKsPVKEEAK
0	11		-	gap
0	14		S628-p	PVKEEAKsPAEVKsP
0	3		-	gap
0	11		S634-p	KsPAEVKsPEKAKsP
0	9		S640-p	KsPEKAKsPTKEEAK
0	10		T642	PEKAKsPTKEEAKsP
0	13		S648-p	PTKEEAKsPEKAKsP
0	11		S654-p	KsPEKAKsPEkAksP
0	1		K657-a	EKAKsPEkAksPEkE
0	1		K659-a	AKsPEkAksPEkEEA
0	1		K659-u	AKsPEkAksPEkEEA
0	10		S660-p	KsPEkAksPEkEEAK
0	1		K663-a	EkAksPEkEEAKsPE
0	6		-	gap
0	1		K667	sPEkEEAKsPEKAKs
0	13		S668-p	PEkEEAKsPEKAKsP
0	14		S674-p	KsPEKAKsPVKAEAK
0	9		-	gap
0	6		-	gap
0	8		-	gap
0	10		-	gap
0	11		-	gap
0	11		-	gap
0	14		S682-p	PVKAEAKsPEKAKsP
0	10		S688-p	KsPEKAKsPVKAEAK
0	10		-	gap
0	19		S696-p	PVKAEAKsPEKAKsP
0	17		S702-p	KsPEKAKsPVKEEAK
0	16		A708	KsPVKEEAKsPEKAK
0	12		S710-p	PVKEEAKsPEKAKsP
0	5		S716-p	KsPEKAKsPVKEEAK
0	4		-	gap
0	7		S724-p	PVKEEAKsPEKAKsP
0	6		S730-p	KsPEKAKsPVKEEAK
0	2		T738-p	PVKEEAKtPEKAKsP
0	5		S744-p	KtPEKAKsPVKEEAK
0	2		A750	KsPVKEEAKsPEKAK
0	3		S752-p	PVKEEAKsPEKAKsP
0	2		S758-p	KsPEKAKsPEKAKTL
0	9		S769-p	AKTLDVKsPEAKTPA
0	4		T774	VKsPEAKTPAKEEAR
0	1		S782-p	PAKEEARsPADKFPE
0	1		A784	KEEARsPADKFPEKA
0	6		S793-p	KFPEKAKsPVKEEVK
0	7		S801-p	PVKEEVKsPEKAKSP
0	11		S828-p	PKKEEVKsPVKEEEK
0	1		P886	KVEEKKEPAVEKPKE
0	1		V888	EEKKEPAVEKPKESK
0	1		K907-a	KEEAEDKkkVPtPEK
0	1		K908-a	EEAEDKkkVPtPEKE
0	2		T911-p	EDKkkVPtPEKEAPA
0	1		P912	DKkkVPtPEKEAPAK
0	1		A935	PKEKTEVAKKEPDDA
0	2		S948-p	DAKAKEPsKPAEKKE
0	1		K953	EPsKPAEKKEAAPEK

	mouse ► Hide Isoforms
K31	LHYSLSRKAGPGGTR
S39-g	AGPGGTRsAAGSSSG
T53	GFHSWARTSVSSVsA
S54	FHSWARTSVSSVsAs
S56	SWARTSVSSVsAsPS
S59-p	RTSVSSVsAsPSRFR
S61-p	SVSSVsAsPSRFRGA
S63	SSVsAsPSRFRGAAs
S70-p	SRFRGAAsStDsLDt
T72-p	FRGAAsStDsLDtLS
S74-p	GAAsStDsLDtLSNG
T77-p	sStDsLDtLSNGPEG
K96-u	AVAARSEkEQLQALN
Y109	LNDRFAGYIDKVRQL
S122-p	QLEAHNRsLEGEAAA
Y227	ALQEECGYLRRHHQE
K262-u	AEARDALkCDVTSAL
K303-u	DRLSEAAkVNTDAMR
Y319	AQEEITEYRRQLQAR
S335	TELEALKSTKESLER
Y383	MAAQLREYQDLLNVK
Y400	LDIEIAAYRkLLEGE
K402-u	IEIAAYRkLLEGEEC
S416-p	CRIGFGPsPFsLtEG
S419-p	GFGPsPFsLtEGLPk
T421-p	GPsPFsLtEGLPkIP
K426-u	sLtEGLPkIPsIsTH
S429-p	EGLPkIPsIsTHIKV
S431-g	LPkIPsIsTHIKVKs
S438-p	sTHIKVKsEEMIkVV
K443-u	VKsEEMIkVVEKSEK
T499-p	EEEGAAAtsPPAEEA
S500-p	EEGAAAtsPPAEEAA
S508-p	PPAEEAAsPEKEtKS
T513-p	AAsPEKEtKSRVKEE
S515	sPEKEtKSRVKEEAK
S523-p	RVKEEAKsPGEAKsP
K528	AKsPGEAKsPGEAKs
S529-p	KsPGEAKsPGEAKsP
S535-p	KsPGEAKsPAEAKsP
S541-p	KsPAEAKsPGEAKsP
S547-p	KsPGEAKsPGEAKsP
S553-p	KsPGEAKsPGEAksP
K558-a	AKsPGEAksPAEPKs
K558	AKsPGEAKsPAEPKs
S559-p	KsPGEAksPAEPKsP
S565-p	ksPAEPKsPAEPKsP
S571-p	KsPAEPKsPAEAKsP
S577-p	KsPAEAKsPAEPKsP
S583-p	KsPAEPKsPAtVKsP
T586-p	AEPKsPAtVKsPGEA
S589-p	KsPAtVKsPGEAKsP
S595-p	KsPGEAKsPSEAKsP
S601-p	KsPSEAKsPAEAKsP
S607-p	KsPAEAKsPAEAKsP
S613-p	KsPAEAKsPAEAKsP
S619-p	KsPAEAKsPAEAKsP
S625-p	KsPAEAKsPAEAKsP
S631-p	KsPAEAKsPAEAKsP
S637-p	KsPAEAKsPAtVKsP
T640-p	AEAKsPAtVKsPGEA
S643-p	KsPAtVKsPGEAKsP
S649-p	KsPGEAKsPSEAKsP
S655-p	KsPSEAKsPAEAKsP
S661-p	KsPAEAKsPAEAKsP
S667-p	KsPAEAKsPAEAKsP
E670	AEAKsPAEAKsPAEV
K672	AKsPAEAKsPAEVKs
K672	AKsPAEAKsPAEVKs
S673-p	KsPAEAKsPAEVKsP
E676	AEAKsPAEVKsPGEA
S679-p	KsPAEVKsPGEAksP
K684-a	VKsPGEAksPAEPKs
S685-p	KsPGEAksPAEPKsP
S691-p	ksPAEPKsPAEAKsP
S697-p	KsPAEAKsPAEVKsP
S703-p	KsPAEVKsPAEAKsP
S709-p	KsPAEAKsPAEVKsP
S715-p	KsPAEVKsPGEAKsP
S721-p	KsPGEAKsPAAVKsP
S727-p	KsPAAVKsPAEAKsP
S733-p	KsPAEAKsPAAVKsP
S739-p	KsPAAVKsPGEAKsP
S745-p	KsPGEAKsPGEAKsP
S751-p	KsPGEAKsPAEAKsP
S757-p	KsPAEAKsPAEAKsP
S763-p	KsPAEAKsPIEVKsP
S769-p	KsPIEVKsPEKAKtP
T775-p	KsPEKAKtPVKEGAK
S783-p	PVKEGAKsPAEAKsP
S789-p	KsPAEAKsPEKAKsP
S795-p	KsPEKAKsPVKEDIK
P803	PVKEDIKPPAEAKsP
S809-p	KPPAEAKsPEKAKsP
S815-p	KsPEKAKsPVKEGAK
V817	PEKAKsPVKEGAKPP
P823	PVKEGAKPPEKAKPL
S834-p	AKPLDVKsPEAQtPV
T839-p	VKsPEAQtPVQEEAK
H847	PVQEEAKHPtDIRPP
T849-p	QEEAKHPtDIRPPEQ
S859-p	RPPEQVKsPAKEKAK
S867-p	PAKEKAKsPEKEEAK
S888-p	PKKEEVKsPVKEEVK
T939-p	KVEEKKEtPtEKPKD
T941-p	EEKKEtPtEKPKDST
K960	KEEAGEKKKAVAsEE
K961	EEAGEKKKAVAsEEE
A964	GEKKKAVAsEEETPA
S965-p	EKKKAVAsEEETPAK
T988-p	PKEKTETtKTEAEDT
S1001-p	DTKAKEPsKPTETEK
-	gap

	NFH iso3
K31	LHYSLSRKAGPGGTR
S39	AGPGGTRSAAGSSSG
T53	GFHSWARTSVSSVSA
S54	FHSWARTSVSSVSAS
S56	SWARTSVSSVSASPS
S59	RTSVSSVSASPSRFR
S61	SVSSVSASPSRFRGA
S63	SSVSASPSRFRGAAS
S70	SRFRGAASSTDSLDT
T72	FRGAASSTDSLDTLS
S74	GAASSTDSLDTLSNG
T77	SSTDSLDTLSNGPEG
K96	AVAARSEKEQLQALN
Y109	LNDRFAGYIDKVRQL
S122	QLEAHNRSLEGEAAA
Y227	ALQEECGYLRRHHQE
K262	AEARDALKCDVTSAL
K303	DRLSEAAKVNTDAMR
Y319	AQEEITEYRRQLQAR
S335	TELEALKSTKESLER
Y383	MAAQLREYQDLLNVK
Y400	LDIEIAAYRKLLEGE
K402	IEIAAYRKLLEGEEC
S416	CRIGFGPSPFSLTEG
S419	GFGPSPFSLTEGLPK
T421	GPSPFSLTEGLPKIP
K426	SLTEGLPKIPSISTH
S429	EGLPKIPSISTHIKV
S431	LPKIPSISTHIKVKS
S438	STHIKVKSEEMIKVV
K443	VKSEEMIKVVEKSEK
T499	EEEGAAATSPPAEEA
S500	EEGAAATSPPAEEAA
S508	PPAEEAASPEKETKS
T513	AASPEKETKSRVKEE
S515	SPEKETKSRVKEEAK
S523	RVKEEAKSPGEAKSP
K528	AKSPGEAKSPGEAKS
S529	KSPGEAKSPGEAKSP
S541	KSPGEAKSPAEAKSP
S547	KSPAEAKSPGEAKSP
S553	KSPGEAKSPREAKSP
S559	KSPREAKSPGEAKSP
K564	AKSPGEAKSPAEPKS
K564	AKSPGEAKSPAEPKS
S565	KSPGEAKSPAEPKSP
S571	KSPAEPKSPAEPKSP
S577	KSPAEPKSPAEAKSP
S583	KSPAEAKSPAEPKSP
S589	KSPAEPKSPATVKSP
T592	AEPKSPATVKSPGEA
S595	KSPATVKSPGEAKSP
S601	KSPGEAKSPSEAKSP
S607	KSPSEAKSPAEAKSP
S613	KSPAEAKSPAEAKSP
S619	KSPAEAKSPAEAKSP
S625	KSPAEAKSPAEAKSP
S631	KSPAEAKSPAEAKSP
S637	KSPAEAKSPAEAKSP
S643	KSPAEAKSPATVKSP
T646	AEAKSPATVKSPGEA
S649	KSPATVKSPGEAKSP
S655	KSPGEAKSPSEAKSP
S661	KSPSEAKSPAEAKSP
S667	KSPAEAKSPAEAKSP
S673	KSPAEAKSPAEAKSP
E676	AEAKSPAEAKSPAEV
K678	AKSPAEAKSPAEVKS
K678	AKSPAEAKSPAEVKS
S679	KSPAEAKSPAEVKSP
E682	AEAKSPAEVKSPGEA
S685	KSPAEVKSPGEAKSP
K690	VKSPGEAKSPAEPKs
S691	KSPGEAKSPAEPKsP
S697-p	KSPAEPKsPAEAKsP
S703-p	KsPAEAKsPAAVKsP
-	gap
-	gap
-	gap
-	gap
S709-p	KsPAAVKsPAEAKSP
S715	KsPAEAKSPAAVKSP
S721	KSPAAVKSPGEAKSP
S727	KSPGEAKSPGEAKSP
S733	KSPGEAKSPAEAKSP
S739	KSPAEAKSPAEAKSP
S745	KSPAEAKSPIEVKSP
S751	KSPIEVKSPEKAKTP
T757	KSPEKAKTPVKEGAK
S765	PVKEGAKSPAEAKSP
S771	KSPAEAKSPEKAKSP
S777	KSPEKAKSPVKEDIK
P785	PVKEDIKPPAEAKSP
S791	KPPAEAKSPEKAKsP
S797-p	KSPEKAKsPMKEGAK
M799	PEKAKsPMKEGAKPP
P805	PMKEGAKPPEKAKPL
S816	AKPLDVKSPEAQTPV
T821	VKSPEAQTPVQEEAN
D829	PVQEEANDPTDIRPP
T831	QEEANDPTDIRPPEQ
S841	RPPEQVKSPAKEKAK
S849	PAKEKAKSPEKEEAK
S870	PKKEEVKSPVKEEVK
T921	KVEEKKETPTEKPKD
T923	EEKKETPTEKPKDST
K942	KEEAGEKKKAVASEE
K943	EEAGEKKKAVASEEE
A946	GEKKKAVASEEETPA
S947	EKKKAVASEEETPAK
T970	PKEKTETTKTEAEDT
S983	DTKAKEPSKPTETEK
-	gap

	rat
K31	LHYALSRKAGAGGTR
S39	AGAGGTRSAAGSSSG
T53-g	GFHSWARtsVsSVSA
S54-g	FHSWARtsVsSVSAS
S56-g	SWARtsVsSVSASPS
S59	RtsVsSVSASPSRFR
S61	sVsSVSASPSRFRGA
S63	sSVSASPSRFRGAAS
S70	SRFRGAASSTDSLDT
T72	FRGAASSTDSLDTLS
S74	GAASSTDSLDTLSNG
T77	SSTDSLDTLSNGPEG
K95	AVAARSEKEQLQALN
Y108	LNDRFAGYIDKVRQL
T121	QLEAHNRTLEGEAAA
Y225-p	ALQEECGyLRRHHQE
K260	AEARDALKCDVTSAL
K301	DRLSEAAKVNTDAMR
Y317-p	AQEEITEyRRQLQAR
S333	TELEALKSTKESLER
Y381-p	MAAQLREyQDLLNVK
Y398-p	LDIEIAAyRKLLEGE
K400	IEIAAyRKLLEGEEC
S414	CRIGFGPSPFSLTEG
S417	GFGPSPFSLTEGLPK
T419	GPSPFSLTEGLPKIP
K424	SLTEGLPKIPSMSTH
S427	EGLPKIPSMSTHIKV
S429	LPKIPSMSTHIKVKS
S436	STHIKVKSEEKIKVV
K441	VKSEEKIKVVEKSEK
T491	EGGEEAATTsPPAEE
S493-p	GEEAATTsPPAEEAA
S501-p	PPAEEAAsPEKETKS
T506	AAsPEKETKSPVKEE
S508	sPEKETKSPVKEEAK
S516	PVKEEAKSPAEAKSP
K521	AKSPAEAKSPAEAKS
S522	KSPAEAKSPAEAKSP
S534	KSPAEAKSPAEVKSP
S540	KSPAEVKSPAEVKSP
S546	KSPAEVKSPAEAKSP
S552	KSPAEAKSPAEAKSP
K557	AKSPAEAKSPAEVKS
K557	AKSPAEAKSPAEVKS
S558	KSPAEAKSPAEVKSP
S564	KSPAEVKSPAEVKSP
S570	KSPAEVKSPAEAKSP
S576	KSPAEAKSPAEAKSP
S582	KSPAEAKSPAEVKSP
T591	AEVKSPATVKSPGEA
S594	KSPATVKSPGEAKSP
S600	KSPGEAKSPAEAKSP
S606	KSPAEAKSPAEVKSP
S612	KSPAEVKSPVEAKSP
S618	KSPVEAKSPAEAKSP
S624	KSPAEAKSPASVKSP
S630	KSPASVKSPGEAKSP
S636	KSPGEAKSPAEAKSP
S642	KSPAEAKSPAEVKSP
-	gap
S648	KSPAEVKSPATVKSP
S654	KSPATVKSPVEAKSP
S660	KSPVEAKSPAEVKSP
S666	KSPAEVKSPVTVKSP
S672	KSPVTVKSPAEAKSP
E675	VTVKSPAEAKSPVEV
K677	VKSPAEAKSPVEVKS
K677	VKSPAEAKSPVEVKS
S678	KSPAEAKSPVEVKSP
E681	AEAKSPVEVKSPASV
S684	KSPVEVKSPASVKSP
K689	VKSPASVKSPSEAKS
S690	KSPASVKSPSEAKSP
S696	KSPSEAKSPAGAKSP
S702	KSPAGAKSPAEAKSP
S708	KSPAEAKSPVVAKSP
S714	KSPVVAKSPAEAKSP
-	gap
-	gap
S720	KSPAEAKSPAEAKPP
P726	KSPAEAKPPAEAKSP
S732	KPPAEAKSPAEAKSP
S738	KSPAEAKSPAEAKSP
S744	KSPAEAKSPAEAKSP
S750	KSPAEAKSPAEAKSP
S756	KSPAEAKSPVEVKsP
S762-p	KSPVEVKsPEKAKSP
S768	KsPEKAKSPVKEGAK
S776	PVKEGAKSLAEAKSP
S782	KSLAEAKSPEKAKSP
S788	KSPEKAKSPVKEEIK
P796	PVKEEIKPPAEVKSP
S802	KPPAEVKSPEKAKSP
S808	KSPEKAKSPMKEEAK
M810	PEKAKSPMKEEAKSP
S816	PMKEEAKSPEKAKTL
S827	AKTLDVKSPEAKTPA
T832	VKSPEAKTPAKEEAK
R840	PAKEEAKRPADIRSP
A842	KEEAKRPADIRSPEQ
S852	RSPEQVKSPAKEEAK
S860	PAKEEAKSPEKEETR
S880-p	PKKEEVKsPVEEVKA
P929	PKAEEKEPLTEKPKD
T931	AEEKEPLTEKPKDSP
K949	KKEEAKEKKAAAPEE
K950	KEEAKEKKAAAPEEE
A953	AKEKKAAAPEEETPA
P954	KEKKAAAPEEETPAK
-	gap
S983	DAKAKEPSKPSEkEK
K988-u	EPSKPSEkEKPKKEE

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