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Protein Page:
MST1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MST1 a protein kinase of the STE20 family. Proteolytically activated by caspase during apoptosis. Activated by apoptotic signals as well as other stress conditions. Full activation requires both phosphorylation and caspase-mediated cleavage. Phosphorylation at serine 327 of Mst1, which is close to the caspase-3 recognition site, inhibits caspase-mediated cleavage. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Autophagy; EC 2.7.11.1; Protein kinase, STE; Kinase, protein; STE group; STE20 family; MST subfamily
Chromosomal Location of Human Ortholog: 20q11.2-q13.2
Cellular Component: cytoplasm; nucleus; cytosol
Molecular Function: protein dimerization activity; protein serine/threonine kinase activity; identical protein binding; protein serine/threonine kinase activator activity; protein binding; protein homodimerization activity; magnesium ion binding; transcription factor binding; ATP binding
Biological Process: central nervous system development; positive regulation of apoptosis; apoptosis; protein amino acid autophosphorylation; cell morphogenesis; signal transduction; negative regulation of organ growth; protein amino acid phosphorylation; keratinocyte differentiation; patterning of blood vessels; negative regulation of cell proliferation; peptidyl-serine phosphorylation; neural tube formation
Reference #:  Q13043 (UniProtKB)
Alt. Names/Synonyms: dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2)); DKFZp686A2068; kinase responsive to stress 2; KRS2; Mammalian STE20-like protein kinase 1; mammalian sterile 20-like 1; MST-1; MST1; serine/threonine kinase 4; Serine/threonine-protein kinase 4; Serine/threonine-protein kinase Krs-2; STE20-like kinase MST1; STK4; yeast Ste20-like; YSK3
Gene Symbols: STK4
Molecular weight: 55,630 Da
Basal Isoelectric point: 4.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MST1

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
apoptosis, altered: S82‑p, T120‑p, T387‑p
enzymatic activity, induced: S82‑p, T183‑p, T387‑p
enzymatic activity, inhibited: T120‑p
intracellular localization: S82‑p, T120‑p, T183‑p
molecular association, regulation: S82‑p
phosphorylation: T120‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T3-p _____MEtVQLRNPP
0 1 K35-ac EVFDVLEkLGEGsyG
0 25 S40-p LEkLGEGsyGsVyKA
0 16 Y41-p EkLGEGsyGsVyKAI
0 5 S43-p LGEGsyGsVyKAIHK
0 3 Y45-p EGsyGsVyKAIHKET
1 0 S82-p SIMQQCDsPHVVKYY
0 2 K119-ub DIIRLRNktLTEDEI
3 0 T120-p IIRLRNktLTEDEIA
0 1 S132-p EIATILQsTLKGLEY
0 1 K164-ub LNTEGHAkLADFGVA
1 7 T177-p VAGQLTDtMAkRNtV
0 2 K180-ub QLTDtMAkRNtVIGT
11 5 T183-p DtMAkRNtVIGTPFW
0 1 S265-p VKQCLVKsPEQRATA
0 11 S307-p VKLKRQEsQQREVDQ
0 47 S320-p DQDDEENsEEDEMDs
2 1 S327-p sEEDEMDsGtMVRAV
0 6 T329-p EDEMDsGtMVRAVGD
1 26 T340-p AVGDEMGtVRVASTM
0 1 T346 GtVRVASTMTDGANT
0 1 T360-p TMIEHDDtLPSQLGt
0 1 T367-p tLPSQLGtMVINAED
0 6 T380-p EDEEEEGtMKRRDEt
3 9 T387-p tMKRRDEtMQPAKPs
0 1 S394-p tMQPAKPsFLEyFEQ
0 17 Y398-p AKPsFLEyFEQKEKE
0 4 S410-p EKENQINsFGKsVPG
0 2 S414-p QINsFGKsVPGPLKN
0 4 P418 FGKsVPGPLKNssDW
0 2 S422-p VPGPLKNssDWKIPQ
0 1 S423-p PGPLKNssDWKIPQD
1 119 Y433-p KIPQDGDyEFLKsWt
0 6 S438-p GDyEFLKsWtVEDLQ
0 1 T440-p yEFLKsWtVEDLQKR
3681 : Phospho-Mst1 (Thr183)/Mst2 (Thr180) Antibody
  mouse

 
T3 _____METVQLRNPP
K35 EVFDVLEKLGEGSYG
S40 LEKLGEGSYGSVYKA
Y41 EKLGEGSYGSVYKAI
S43 LGEGSYGSVYKAIHK
Y45 EGSYGSVYKAIHKET
S82 SIMQQCDSPHVVKYY
K119 DIIRLRNKTLTEDEI
T120 IIRLRNKTLTEDEIA
S132 EIATILQSTLKGLEY
K164 LNTEGHAKLADFGVA
T177-p VAGQLTDtMAKRNtV
K180 QLTDtMAKRNtVIGT
T183-p DtMAKRNtVIGTPFW
S265 VKQCLVKSPEQRATA
A307 VKLKRQEAQQREVDQ
S320-p DQDDEENsEEDEMDs
S327-p sEEDEMDsGtMVRAA
T329-p EDEMDsGtMVRAAGD
T340-p AAGDEMGtVRVAStM
T346-p GtVRVAStMSGGANT
T360 TMIEHGDTLPSQLGT
T367 TLPSQLGTMVINTED
T380-p EDEEEEGtMKRRDEt
T387-p tMKRRDEtMQPAKPS
S394 tMQPAKPSFLEYFEQ
Y398 AKPSFLEYFEQKEKE
S410 EKENQINSFGKNVSG
N414 QINSFGKNVSGsLKN
S418-p FGKNVSGsLKNSSDW
S422 VSGsLKNSSDWKIPQ
S423 SGsLKNSSDWKIPQD
Y433-p KIPQDGDyEFLKsWT
S438-p GDyEFLKsWTVEDLQ
T440 yEFLKsWTVEDLQKR
3681 : Phospho-Mst1 (Thr183)/Mst2 (Thr180) Antibody
  rat

 
T3 _____METVQLRNPP
K35 EVFDVLEKLGEGsYG
S40-p LEKLGEGsYGSVYKA
Y41 EKLGEGsYGSVYKAI
S43 LGEGsYGSVYKAIHK
Y45 EGsYGSVYKAIHKET
S82 SIMQQCDSPHVVKYY
K119 DIIRLRNKTLTEDEI
T120 IIRLRNKTLTEDEIA
S132 EIATILQSTLKGLEY
K164 LNTEGHAKLADFGVA
T177 VAGQLTDTMAKRNTV
K180 QLTDTMAKRNTVIGT
T183 DTMAKRNTVIGTPFW
S265 VKQCLVKSPEQRATA
A307 VKLKRQEAQQRAVDQ
S320-p DQDDDENsEEDEMDS
S327 sEEDEMDSGTMVRAA
T329 EDEMDSGTMVRAAGD
T340 AAGDDMGTVRVASTM
T346 GTVRVASTMSGGANT
T360 TMIEHGDTLPSQLGT
T367 TLPSQLGTMVINTED
T380 EDEEEEGTMKRRDET
T387 TMKRRDETMQPAKPS
S394 TMQPAKPSFLEYFEQ
Y398 AKPSFLEYFEQKEKE
S410-p EKENQINsFGKNVSG
N414 QINsFGKNVSGsLKN
S418-p FGKNVSGsLKNSSDW
S422 VSGsLKNSSDWKIPQ
S423 SGsLKNSSDWKIPQD
Y433 KIPQDGDYEFLKSWT
S438 GDYEFLKSWTVEDLQ
T440 YEFLKSWTVEDLQKR
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