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MST1 (human)

Overview MST1 a protein kinase of the STE20 family. Proteolytically activated by caspase during apoptosis. Activated by apoptotic signals as well as other stress conditions. Full activation requires both phosphorylation and caspase-mediated cleavage. Phosphorylation at serine 327 of Mst1, which is close to the caspase-3 recognition site, inhibits caspase-mediated cleavage. Note: This description may include information from UniProtKB. Protein type: Autophagy; Kinase, protein; EC 2.7.11.1; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; MST subfamily Cellular Component: cytoplasm; nucleus; cytosol Molecular Function: protein dimerization activity; protein serine/threonine kinase activity; identical protein binding; protein serine/threonine kinase activator activity; protein binding; protein homodimerization activity; magnesium ion binding; transcription factor binding; ATP binding Biological Process: central nervous system development; positive regulation of apoptosis; apoptosis; protein amino acid autophosphorylation; cell morphogenesis; protein kinase cascade; signal transduction; negative regulation of organ growth; protein amino acid phosphorylation; patterning of blood vessels; keratinocyte differentiation; negative regulation of cell proliferation; peptidyl-serine phosphorylation; induction of apoptosis; neural tube formation Reference #:  Q13043 (UniProtKB) Alt. Names/Synonyms: dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2)); DKFZp686A2068; kinase responsive to stress 2; KRS2; Mammalian STE20-like protein kinase 1; mammalian sterile 20-like 1; MST-1; MST1; serine/threonine kinase 4; Serine/threonine-protein kinase 4; Serine/threonine-protein kinase Krs-2; STE20-like kinase MST1; STK4; yeast Ste20-like; YSK3 Gene Symbols: STK4 Molecular weight: 55,630 Da Basal Isoelectric point: 4.97  Predict pI for various phosphorylation states CST Pathways:  Hippo Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MST1 2JO8 - A/B=432-480 (human) 3COM - A/B=2-311 (human) Substrate Sequence Logo

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	Sites Implicated In
apoptosis, altered: S82‑p, T120‑p, T387‑p enzymatic activity, induced: S82‑p, T183‑p, T387‑p enzymatic activity, inhibited: T120‑p intracellular localization: S82‑p, T120‑p, T183‑p molecular association, regulation: S82‑p phosphorylation: T120‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T3-p	_____MEtVQLRNPP
0	1		K35-a	EVFDVLEkLGEGsyG
0	22		S40-p	LEkLGEGsyGsVyKA
0	13		Y41-p	EkLGEGsyGsVyKAI
0	4		S43-p	LGEGsyGsVyKAIHK
0	3		Y45-p	EGsyGsVyKAIHKET
1	0		S82-p	SIMQQCDsPHVVKYY
0	2		K119-u	DIIRLRNktLTEDEI
2	0		T120-p	IIRLRNktLTEDEIA
0	1		S132-p	EIATILQsTLKGLEY
0	1		K164-u	LNTEGHAkLADFGVA
1	3		T177-p	VAGQLTDtMAkRNtV
0	2		K180-u	QLTDtMAkRNtVIGT
8	5		T183-p	DtMAkRNtVIGTPFW
0	1		S265-p	VKQCLVKsPEQRATA
0	11		S307-p	VKLKRQEsQQREVDQ
0	35		S320-p	DQDDEENsEEDEMDs
2	1		S327-p	sEEDEMDsGtMVRAV
0	5		T329-p	EDEMDsGtMVRAVGD
0	18		T340-p	AVGDEMGtVRVAStM
0	1		T346-p	GtVRVAStMTDGANT
0	1		T360-p	TMIEHDDtLPSQLGt
0	1		T367-p	tLPSQLGtMVINAED
0	6		T380-p	EDEEEEGtMKRRDEt
3	8		T387-p	tMKRRDEtMQPAKPS
0	17		Y398-p	AKPSFLEyFEQKEKE
0	2		S410-p	EKENQINsFGKsVPG
0	1		S414-p	QINsFGKsVPGPLKN
0	2		P418	FGKsVPGPLKNssDW
0	2		S422-p	VPGPLKNssDWKIPQ
0	1		S423-p	PGPLKNssDWKIPQD
1	127		Y433-p	KIPQDGDyEFLKsWt
0	5		S438-p	GDyEFLKsWtVEDLQ
0	1		T440-p	yEFLKsWtVEDLQKR

	mouse
T3	_____METVQLRNPP
K35	EVFDVLEKLGEGSYG
S40	LEKLGEGSYGSVYKA
Y41	EKLGEGSYGSVYKAI
S43	LGEGSYGSVYKAIHK
Y45	EGSYGSVYKAIHKET
S82	SIMQQCDSPHVVKYY
K119	DIIRLRNKTLTEDEI
T120	IIRLRNKTLTEDEIA
S132	EIATILQSTLKGLEY
K164	LNTEGHAKLADFGVA
T177-p	VAGQLTDtMAKRNtV
K180	QLTDtMAKRNtVIGT
T183-p	DtMAKRNtVIGTPFW
S265	VKQCLVKSPEQRATA
A307	VKLKRQEAQQREVDQ
S320-p	DQDDEENsEEDEMDs
S327-p	sEEDEMDsGTMVRAA
T329	EDEMDsGTMVRAAGD
T340	AAGDEMGTVRVAStM
T346-p	GTVRVAStMSGGANT
T360	TMIEHGDTLPSQLGT
T367	TLPSQLGTMVINTED
T380-p	EDEEEEGtMKRRDEt
T387-p	tMKRRDEtMQPAKPS
Y398	AKPSFLEYFEQKEKE
S410	EKENQINSFGKNVSG
N414	QINSFGKNVSGsLKN
S418-p	FGKNVSGsLKNSSDW
S422	VSGsLKNSSDWKIPQ
S423	SGsLKNSSDWKIPQD
Y433-p	KIPQDGDyEFLKsWT
S438-p	GDyEFLKsWTVEDLQ
T440	yEFLKsWTVEDLQKR

	rat
T3	_____METVQLRNPP
K35	EVFDVLEKLGEGsYG
S40-p	LEKLGEGsYGSVYKA
Y41	EKLGEGsYGSVYKAI
S43	LGEGsYGSVYKAIHK
Y45	EGsYGSVYKAIHKET
S82	SIMQQCDSPHVVKYY
K119	DIIRLRNKTLTEDEI
T120	IIRLRNKTLTEDEIA
S132	EIATILQSTLKGLEY
K164	LNTEGHAKLADFGVA
T177	VAGQLTDTMAKRNTV
K180	QLTDTMAKRNTVIGT
T183	DTMAKRNTVIGTPFW
S265	VKQCLVKSPEQRATA
A307	VKLKRQEAQQRAVDQ
S320	DQDDDENSEEDEMDS
S327	SEEDEMDSGTMVRAA
T329	EDEMDSGTMVRAAGD
T340	AAGDDMGTVRVASTM
T346	GTVRVASTMSGGANT
T360	TMIEHGDTLPSQLGT
T367	TLPSQLGTMVINTED
T380	EDEEEEGTMKRRDET
T387	TMKRRDETMQPAKPS
Y398	AKPSFLEYFEQKEKE
S410	EKENQINSFGKNVSG
N414	QINSFGKNVSGSLKN
S418	FGKNVSGSLKNSSDW
S422	VSGSLKNSSDWKIPQ
S423	SGSLKNSSDWKIPQD
Y433	KIPQDGDYEFLKSWT
S438	GDYEFLKSWTVEDLQ
T440	YEFLKSWTVEDLQKR

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