a protein kinase of the STE20 family. Activated by apoptotic signals as well as other stress conditions. Full activation requires both phosphorylation and caspase-mediated cleavage. Following cleavage by caspase-3, undergoes irreversible autophosphorylation. Full-length is mainly unphosphorylated in the rat thymus and cultured cells, whereas caspase-3-cleaved MST2 in apoptotic cells is highly phosphorylated. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 220.127.116.11; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); Autophagy; STE group; STE20 family; MST subfamily
Chromosomal Location of Human Ortholog: 8q22.2
Cellular Component: cytoplasm; nucleus; cytosol
Molecular Function: protein dimerization activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding; protein kinase activity
Biological Process: positive regulation of apoptosis; apoptosis; signal transduction; protein amino acid phosphorylation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.