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Protein Page:
MST2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MST2 a protein kinase of the STE20 family. Activated by apoptotic signals as well as other stress conditions. Full activation requires both phosphorylation and caspase-mediated cleavage. Following cleavage by caspase-3, undergoes irreversible autophosphorylation. Full-length is mainly unphosphorylated in the rat thymus and cultured cells, whereas caspase-3-cleaved MST2 in apoptotic cells is highly phosphorylated. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Protein kinase, STE; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; MST subfamily
Cellular Component: cytoplasm; nucleus; cytosol
Molecular Function: protein dimerization activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding; protein kinase activity
Biological Process: positive regulation of apoptosis; apoptosis; signal transduction; protein amino acid phosphorylation
Reference #:  Q13188 (UniProtKB)
Alt. Names/Synonyms: FLJ90748; KRS1; Mammalian STE20-like protein kinase 2; MST-2; MST2; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); Serine/threonine-protein kinase 3; Serine/threonine-protein kinase Krs-1; STE20-like kinase MST2; STK3
Gene Symbols: STK3
Molecular weight: 56,301 Da
Basal Isoelectric point: 5.12  Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MST2

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
apoptosis, altered: T117‑p, T180‑p, T384‑p
carcinogenesis, induced: T117‑p
cell growth, altered: T117‑p
signaling pathway regulation: T117‑p, T180‑p, T384‑p
enzymatic activity, induced: Y81‑p, T180‑p
enzymatic activity, inhibited: T117‑p, T384‑p
intracellular localization: T117‑p
molecular association, regulation: Y81‑p, T117‑p, T384‑p
phosphorylation: T117‑p
protein processing: T180‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 6 S15-p KSKLKKLsEDsLTKQ
1 0 S18-p LKKLsEDsLTKQPEE
0 1 K56-ub SGQVVAIkQVPVESD
1 0 Y81-p MQQCDSPyVVKYYGS
0 1 K116-ub DIIRLRNktLIEDEI
2 1 T117-p IIRLRNktLIEDEIA
0 1 K161-ub LNTEGHAkLADFGVA
0 6 T174-p VAGQLTDtMAkRNtV
0 2 K177-ub QLTDtMAkRNtVIGT
8 5 T180-p DtMAkRNtVIGTPFW
0 1 K243-ub NPPPTFRkPELWSDD
0 1 K298-ub ITEAMEIkAKRHEEQ
1 37 S316-p LEEEEENsDEDELDs
0 1 S323-p sDEDELDsHtMVKTS
0 1 T325-p EDELDsHtMVKTSVE
0 8 S333-p MVKTSVEsVGtMRAT
0 26 T336-p TSVEsVGtMRATSTM
1 40 T384-p GTMKRNAtsPQVQRP
0 19 S385-p TMKRNAtsPQVQRPs
0 10 S392-p sPQVQRPsFMDyFDK
0 10 Y396-p QRPsFMDyFDKQDFK
0 3 S444-p FDFLKNLsLEELQMR
3681 : Phospho-Mst1 (Thr183)/Mst2 (Thr180) Antibody
  mouse

 
S15-p KSKLKKLsEDSLTKQ
S18 LKKLsEDSLTKQPEE
K56 SGQVVAIKQVPVESD
Y81-p MQQCDSPyVVKYYGS
K116 DIIRLRNKTLTEDEI
T117 IIRLRNKTLTEDEIA
K161 LNTEGHAKLADFGVA
T174-p VAGQLTDtMAKRNtV
K177 QLTDtMAKRNtVIGT
T180-p DtMAKRNtVIGTPFW
K243 NPPPTFRKPELWSDD
K298 IAEAMEIKAKRHEEQ
S316-p LEEEEENsDEDELDs
S323-p sDEDELDsHTMVKTS
T325 EDELDsHTMVKTSSE
S333 MVKTSSESVGtMRAT
T336-p TSSESVGtMRATSTM
T390-p GTMKRNAtsPQVQRP
S391-p TMKRNAtsPQVQRPs
S398-p sPQVQRPsFMDYFDK
Y402 QRPsFMDYFDKQDFK
S450 FDFLKNLSLEELQMR
3681 : Phospho-Mst1 (Thr183)/Mst2 (Thr180) Antibody
  rat

 
S15 KSKLKKLSEDSLTKQ
S18 LKKLSEDSLTKQPEE
K56 SGQVVAIKQVPVESD
Y81 MQQCDSPYVVKYYGS
K116 DIIRLRNKTLTEDEI
T117 IIRLRNKTLTEDEIA
K161 LNTEGHAKLADFGVA
T174 VAGQLTDTMAKRNtV
K177 QLTDTMAKRNtVIGT
T180-p DTMAKRNtVIGTPFW
K243 NPPPTFRKPELWSDD
K298 ITEGMEIKAKRHEEQ
S316-p LEDEEENsDEDELDS
S323 sDEDELDSHTMVKTS
T325 EDELDSHTMVKTSSE
G333 MVKTSSEGVGTMRAT
T336 TSSEGVGTMRATSTM
T384 GTMKRNATSPQVQRP
S385 TMKRNATSPQVQRPS
S392 SPQVQRPSFMDYFDK
Y396 QRPSFMDYFDKQDFK
S444 FDFLKNLSLEELQMR
3681 : Phospho-Mst1 (Thr183)/Mst2 (Thr180) Antibody
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