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MST3 (human)

Overview MST3 a protein kinase of the STE20 family. Activated by caspase-mediated cleavage Note: This description may include information from UniProtKB. Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Protein kinase, STE; STE group; STE20 family; YSK subfamily Cellular Component: nucleoplasm; membrane; cytoplasm; cytosol; nucleus Molecular Function: protein serine/threonine kinase activity; protein binding; metal ion binding; ATP binding; protein kinase activity Biological Process: regulation of axon regeneration; apoptosis; protein amino acid autophosphorylation; induction of apoptosis; signal transduction; negative regulation of cell migration; induction of apoptosis by oxidative stress; protein amino acid phosphorylation; cell structure disassembly during apoptosis Reference #:  Q9Y6E0 (UniProtKB) Alt. Names/Synonyms: Mammalian STE20-like protein kinase 3; MST-3; MST3; MST3B; serine/threonine kinase 24 (STE20 homolog, yeast); Serine/threonine-protein kinase 24; STE20; STE20-like kinase 3; STE20-like kinase MST3; sterile 20-like kinase 3; STK24; STK3 Gene Symbols: STK24 Molecular weight: 49,308 Da Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MST3 3CKW - A=31-323 (human) 3CKX - A=31-323 (human) 3ZHP - D/C=19-289 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3CKW 3CKX 3ZHP  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell motility, altered: T190‑p activation: T18‑p enzymatic activity, induced: T190‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	13		-	gap
0	3		-	gap
1	1		T18-p	ALNKRRAtLPHPGGS
0	2		K44-u	TKLEKIGkGSFGEVF
0	3		Y93-p	LSQCDSPyVTKYYGS
0	3		T182-p	FGVAGQLtDtQIkRN
1	32		T184-p	VAGQLtDtQIkRNtF
0	5		K187-u	QLtDtQIkRNtFVGt
2	113		T190-p	DtQIkRNtFVGtPFW
1	13		T194-p	kRNtFVGtPFWMAPE
0	2		K238-u	HSELHPMkVLFLIPK
0	1		K245	kVLFLIPKNNPPTLE
0	5		K292-u	FILRNAKkTsYLTEL
0	1		S294-p	LRNAKkTsYLTELID
0	1		Y303-p	LTELIDRyKRWKAEQ
0	1		S311	KRWKAEQSHDDsssE
0	2		S315-p	AEQSHDDsssEDSDA
0	1		S316-p	EQSHDDsssEDSDAE
0	1		S317-p	QSHDDsssEDSDAET
0	1		A353	PKNLENGALQPSDLD
0	2		S434-p	VQRLQRYsLSGGGTS

	MST3 iso2
S4-p	____MAHsPVQsGLP
S8-p	MAHsPVQsGLPGMQN
-	gap
K32	TKLEKIGKGSFGEVF
Y81	LSQCDSPYVTKYYGS
T170	FGVAGQLTDtQIKRN
T172-p	VAGQLTDtQIKRNtF
K175	QLTDtQIKRNtFVGt
T178-p	DtQIKRNtFVGtPFW
T182-p	KRNtFVGtPFWMAPE
K226	HSELHPMKVLFLIPK
K233	KVLFLIPKNNPPTLE
K280	FILRNAKKTSYLTEL
S282	LRNAKKTSYLTELID
Y291	LTELIDRYKRWKAEQ
S299	KRWKAEQSHDDSSSE
S303	AEQSHDDSSSEDSDA
S304	EQSHDDSSSEDSDAE
S305	QSHDDSSSEDSDAET
A341	PKNLENGALQPSDLD
S422	VQRLQRYSLSGGGTS

	mouse
S4-p	____MAHsPVQsGLP
S8-p	MAHsPVQsGLPGMQN
-	gap
K32	TKLEKIGKGSFGEVF
Y81-p	LSQCDSPyVTKYYGS
T170-p	FGVAGQLtDtQIKRN
T172-p	VAGQLtDtQIKRNtF
K175	QLtDtQIKRNtFVGt
T178-p	DtQIKRNtFVGtPFW
T182-p	KRNtFVGtPFWMAPE
K226-u	HSELHPMkVLFLIPk
K233-u	kVLFLIPkNNPPTLE
K280-u	FIIRNAKkTsYLTEL
S282-p	IRNAKkTsYLTELID
Y291	LTELIDRYKRWKAEQ
S299-p	KRWKAEQsHEDsSSE
S303-p	AEQsHEDsSSEDSDV
S304	EQsHEDsSSEDSDVE
S305	QsHEDsSSEDSDVET
T341-p	PKNLENGtLQLSDLE
S422	VQRLQRYSLSGGGAS

	rat
-	gap
-	gap
-	gap
K81	TKLEKIGKGSFGEVF
Y130	LSQCDSPYVTKYYGS
T223	FGVAGQLTDTQIKRN
T225	VAGQLTDTQIKRNtF
K228	QLTDTQIKRNtFVGT
T231-p	DTQIKRNtFVGTPFW
T235	KRNtFVGTPFWMAPE
K279	HSELHPMKVLFLIPK
K286	KVLFLIPKNNPPTLE
K333	FIIRNAKKTSYLTEL
S335	IRNAKKTSYLTELID
Y344	LTELIDRYKRWKAEQ
S352	KRWKAEQSHEDSSSE
S356	AEQSHEDSSSEDSDV
S357	EQSHEDSSSEDSDVE
S358	QSHEDSSSEDSDVET
T394	PKNLENGTLQPSDLE
S475	VQRLQRYSLSGGGAS

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