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Protein Page:
MST3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MST3 a protein kinase of the STE20 family. Activated by caspase-mediated cleavage Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; STE group; STE20 family; YSK subfamily
Chromosomal Location of Human Ortholog: 13q31.2-q32.3
Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; nucleus; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; metal ion binding; ATP binding; protein kinase activity
Biological Process: regulation of axon regeneration; apoptosis; protein amino acid autophosphorylation; signal transduction; induction of apoptosis by oxidative stress; negative regulation of cell migration; protein amino acid phosphorylation; cell structure disassembly during apoptosis
Reference #:  Q9Y6E0 (UniProtKB)
Alt. Names/Synonyms: Mammalian STE20-like protein kinase 3; MST-3; MST3; MST3B; serine/threonine kinase 24 (STE20 homolog, yeast); Serine/threonine-protein kinase 24; STE20; STE20-like kinase 3; STE20-like kinase MST3; sterile 20-like kinase 3; STK24; STK3
Gene Symbols: STK24
Molecular weight: 49,308 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MST3

Protein Structure Not Found.


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Sites Implicated In
cell motility, altered: T190‑p
activity, induced: T18‑p
enzymatic activity, induced: T190‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 18 - gap
0 3 - gap
1 1 T18-p ALNKRRAtLPHPGGS
0 2 K44-ub TKLEKIGkGSFGEVF
1 0 S91 TVLSQCDSPyVTKYY
0 3 Y93-p LSQCDSPyVTKYYGS
0 1 K142 TILREILKGLDYLHS
0 5 T182-p FGVAGQLtDtQIkRN
1 44 T184-p VAGQLtDtQIkRNtF
0 5 K187-ub QLtDtQIkRNtFVGt
3 154 T190-p DtQIkRNtFVGtPFW
1 17 T194-p kRNtFVGtPFWMAPE
0 2 K238-ub HSELHPMkVLFLIPK
0 1 K245 kVLFLIPKNNPPTLE
0 5 K292-ub FILRNAKkTsYLTEL
0 1 S294-p LRNAKkTsYLTELID
0 1 Y303-p LTELIDRyKRWKAEQ
0 1 S311 KRWKAEQSHDDsssE
0 2 S315-p AEQSHDDsssEDSDA
0 1 S316-p EQSHDDsssEDSDAE
0 1 S317-p QSHDDsssEDSDAET
0 1 A353 PKNLENGALQPSDLD
0 1 Y433-p LVQRLQRysLSGGGT
0 2 S434-p VQRLQRysLSGGGTS
  MST3 iso2  
S4-p ____MAHsPVQsGLP
S8-p MAHsPVQsGLPGMQN
- gap
K32 TKLEKIGKGSFGEVF
S79 TVLSQCDSPYVTKYY
Y81 LSQCDSPYVTKYYGS
K130 TILREILKGLDYLHS
T170 FGVAGQLTDtQIKRN
T172-p VAGQLTDtQIKRNtF
K175 QLTDtQIKRNtFVGt
T178-p DtQIKRNtFVGtPFW
T182-p KRNtFVGtPFWMAPE
K226 HSELHPMKVLFLIPK
K233 KVLFLIPKNNPPTLE
K280 FILRNAKKTSYLTEL
S282 LRNAKKTSYLTELID
Y291 LTELIDRYKRWKAEQ
S299 KRWKAEQSHDDSSSE
S303 AEQSHDDSSSEDSDA
S304 EQSHDDSSSEDSDAE
S305 QSHDDSSSEDSDAET
A341 PKNLENGALQPSDLD
Y421 LVQRLQRYSLSGGGT
S422 VQRLQRYSLSGGGTS
  mouse

 
S4-p ____MAHsPVQsGLP
S8-p MAHsPVQsGLPGMQN
- gap
K32 TKLEKIGKGSFGEVF
S79-p TVLSQCDsPyVTKYY
Y81-p LSQCDsPyVTKYYGS
K130-ac TILREILkGLDYLHS
T170-p FGVAGQLtDtQIKRN
T172-p VAGQLtDtQIKRNtF
K175 QLtDtQIKRNtFVGt
T178-p DtQIKRNtFVGtPFW
T182-p KRNtFVGtPFWMAPE
K226-ub HSELHPMkVLFLIPk
K233-ub kVLFLIPkNNPPTLE
K280-ub FIIRNAKkTsYLTEL
S282-p IRNAKkTsYLTELID
Y291 LTELIDRYKRWKAEQ
S299-p KRWKAEQsHEDsSSE
S303-p AEQsHEDsSSEDSDV
S304 EQsHEDsSSEDSDVE
S305 QsHEDsSSEDSDVET
T341-p PKNLENGtLQLSDLE
Y421 LVQRLQRYSLSGGGA
S422 VQRLQRYSLSGGGAS
  rat

 
- gap
- gap
- gap
K81 TKLEKIGKGSFGEVF
S128 TVLSQCDSPYVTKYY
Y130 LSQCDSPYVTKYYGS
K183-ac TILREILkGLDYLHS
T223 FGVAGQLTDtQIKRN
T225-p VAGQLTDtQIKRNtF
K228 QLTDtQIKRNtFVGT
T231-p DtQIKRNtFVGTPFW
T235 KRNtFVGTPFWMAPE
K279 HSELHPMKVLFLIPK
K286 KVLFLIPKNNPPTLE
K333 FIIRNAKKTSYLTEL
S335 IRNAKKTSYLTELID
Y344 LTELIDRYKRWKAEQ
S352 KRWKAEQSHEDSSSE
S356 AEQSHEDSSSEDSDV
S357 EQSHEDSSSEDSDVE
S358 QSHEDSSSEDSDVET
T394 PKNLENGTLQPSDLE
Y474 LVQRLQRYSLSGGGA
S475 VQRLQRYSLSGGGAS
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