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CAB39 (human)

Overview CAB39 a adaptor protein that, together with STRAD-alpha, forms a regulatory complex capable of stimulating the activity of LKB1. Interacts with Mst4, which plays an essential role in brush border formation in intestinal epithelial cells. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold Cellular Component: protein complex; cytosol Molecular Function: protein serine/threonine kinase activity; protein binding; protein kinase activator activity; kinase binding Biological Process: protein heterooligomerization; positive regulation of protein kinase activity; insulin receptor signaling pathway; regulation of fatty acid oxidation; cell cycle arrest Reference #:  Q9Y376 (UniProtKB) Alt. Names/Synonyms: CAB39; calcium binding protein 39; Calcium-binding protein 39; CGI-66; FLJ22682; MO25; Protein Mo25 Gene Symbols: CAB39 Molecular weight: 39,869 Da Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states CST Pathways:  AMPK Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CAB39 1UPK - A=1-341 (human) 1UPL - A/B=1-341 (human) 2WTK - A/D=1-341 (human) 3GNI - A=1-341 (human) 4FZA - A=11-334 (human) 4FZD - A=11-334 (human) 4FZF - A=11-334 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1UPK 1UPL 2WTK 3GNI 4FZA 4FZD 4FZF  |  Phospho3D  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K17	KSPADIVKNLKESMA
0	1		K45-u	KATEEVSkNLVAMKE
0	1		Y207-p	AEFLEQHyDRFFSEY
0	1		K216	RFFSEYEKLLHSENY
0	1		T288	FVANPNKTQPILDIL
0	1		K297-a	PILDILLkNQAkLIE
0	1		K297	PILDILLKNQAkLIE
0	2		K301-u	ILLkNQAkLIEFLsK
0	1		S307-p	AkLIEFLsKFQNDRT
0	2		T324	EQFNDEKTyLVKQIR
0	10		Y325-p	QFNDEKTyLVKQIRD

	mouse
K17-u	KSPADIVkNLKESMA
K45	KATEEVSKNLVAMKE
Y207	AEFLEQHYDRFFSEY
K216-u	RFFSEYEkLLHSENY
T288-p	FVANPNKtQPILDIL
K297	PILDILLKNQTKLIE
K297-u	PILDILLkNQTKLIE
K301	ILLkNQTKLIEFLSK
S307	TKLIEFLSKFQNDRT
T324-p	EQFNDEKtyLVKQIR
Y325-p	QFNDEKtyLVKQIRD

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