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TAZ (human)

Overview TAZ Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP. Interacts (via coiled-coil domain) with SMAD2 (via MH1 domain), SMAD3 and SMAD4. Interacts with MED15, PAX8 and NKX2-1. Interacts with TEAD1, TEAD2, TEAD3 and TEAD4. Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue. Note: This description may include information from UniProtKB. Protein type: Transcription, coactivator/corepressor Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleolus; cytosol; nucleus Molecular Function: protein binding; protein homodimerization activity; transcription coactivator activity; transcription corepressor activity Biological Process: transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; stem cell division; negative regulation of transcription from RNA polymerase II promoter; negative regulation of fat cell differentiation; glomerulus development; osteoblast differentiation; regulation of transcription, DNA-dependent; negative regulation of protein amino acid phosphorylation; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; negative regulation of protein kinase activity; gene expression; positive regulation of transcription from RNA polymerase II promoter Reference #:  Q9GZV5 (UniProtKB) Alt. Names/Synonyms: DKFZp586I1419; FLJ27004; FLJ45718; TAZ; transcriptional co-activator with PDZ-binding motif; Transcriptional coactivator with PDZ-binding motif; WW domain containing transcription regulator 1; WW domain-containing transcription regulator protein 1; WWTR1 Gene Symbols: WWTR1 Molecular weight: 44,101 Da Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TAZ

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	Sites Implicated In
carcinogenesis, inhibited: S89‑p transcription, altered: S89‑p transcription, inhibited: S89‑p intracellular localization: S89‑p protein degradation: S311‑p ubiquitination: S311‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	22		S58-p	SFFKEPDsGsHsRQs
0	20		S60-p	FKEPDsGsHsRQsst
0	28		S62-p	EPDsGsHsRQsstDs
0	48		S65-p	sGsHsRQsstDssGG
0	61		S66-p	GsHsRQsstDssGGH
0	28		T67-p	sHsRQsstDssGGHP
0	35		S69-p	sRQsstDssGGHPGP
0	27		S70-p	RQsstDssGGHPGPR
0	5		S87-p	GGAQHVRsHssPAsL
5	77		S89-p	AQHVRsHssPAsLQL
0	15		S90-p	QHVRsHssPAsLQLG
0	10		S93-p	RsHssPAsLQLGTGA
0	15		S105-p	TGAGAAGsPAQQHAH
0	3		S117-p	HAHLRQQsYDVTDEL
0	1		S307-p	LNGGPYHsREQstDs
1	10		S311-p	PYHsREQstDsGLGL
0	7		T312-p	YHsREQstDsGLGLG
1	7		S314-p	sREQstDsGLGLGCY
1	0		Y321	sGLGLGCYSVPTTPE
0	1		S393-p	VESALNKsEPFLTWL

	mouse
S58	SFFKEPDSGsHsRQs
S60-p	FKEPDSGsHsRQssT
S62-p	EPDSGsHsRQssTDs
S65-p	SGsHsRQssTDssGG
S66-p	GsHsRQssTDssGGH
T67	sHsRQssTDssGGHP
S69-p	sRQssTDssGGHPGP
S70-p	RQssTDssGGHPGPR
S87	GGAQHVRSHssPAsL
S89-p	AQHVRSHssPAsLQL
S90-p	QHVRSHssPAsLQLG
S93-p	RSHssPAsLQLGTGA
G105	TGAGAAGGPAQQHAH
S117	HAHLRQQSYDVTDEL
S302	LNGGPYHSREQSTDs
S306	PYHSREQSTDsGLGL
T307	YHSREQSTDsGLGLG
S309-p	SREQSTDsGLGLGCy
Y316-p	sGLGLGCySVPTTPE
S388	VESALNKSEPFLTWL

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