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Protein Page:
TAZ (human)

Overview
TAZ Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP. Interacts (via coiled-coil domain) with SMAD2 (via MH1 domain), SMAD3 and SMAD4. Interacts with MED15, PAX8 and NKX2-1. Interacts with TEAD1, TEAD2, TEAD3 and TEAD4. Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleolus; nucleus; cytosol
Molecular Function: protein binding; protein homodimerization activity; transcription coactivator activity; transcription corepressor activity
Biological Process: transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; stem cell division; negative regulation of transcription from RNA polymerase II promoter; negative regulation of fat cell differentiation; glomerulus development; osteoblast differentiation; regulation of transcription, DNA-dependent; negative regulation of protein amino acid phosphorylation; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; negative regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; gene expression
Reference #:  Q9GZV5 (UniProtKB)
Alt. Names/Synonyms: DKFZp586I1419; FLJ27004; FLJ45718; TAZ; transcriptional co-activator with PDZ-binding motif; Transcriptional coactivator with PDZ-binding motif; WW domain containing transcription regulator 1; WW domain-containing transcription regulator protein 1; WWTR1
Gene Symbols: WWTR1
Molecular weight: 44,101 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TAZ

Protein Structure Not Found.


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Sites Implicated In
carcinogenesis, inhibited: S89‑p
transcription, altered: S89‑p
transcription, inhibited: S89‑p
intracellular localization: S89‑p
protein degradation: S311‑p
ubiquitination: S311‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 22 S58-p SFFKEPDsGsHsRQs
0 20 S60-p FKEPDsGsHsRQsst
0 29 S62-p EPDsGsHsRQsstDs
0 48 S65-p sGsHsRQsstDssGG
0 61 S66-p GsHsRQsstDssGGH
0 28 T67-p sHsRQsstDssGGHP
0 35 S69-p sRQsstDssGGHPGP
0 27 S70-p RQsstDssGGHPGPR
0 6 S87-p GGAQHVRsHssPAsL
6 85 S89-p AQHVRsHssPAsLQL
0 18 S90-p QHVRsHssPAsLQLG
0 13 S93-p RsHssPAsLQLGtGA
0 1 T98-p PAsLQLGtGAGAAGs
0 16 S105-p tGAGAAGsPAQQHAH
0 3 S117-p HAHLRQQsYDVTDEL
0 1 S295-p MRSITNNsSDPFLNG
1 9 S311-p PYHSREQstDsGLGL
0 6 T312-p YHSREQstDsGLGLG
1 6 S314-p SREQstDsGLGLGCY
1 0 Y321 sGLGLGCYSVPTTPE
0 1 S393-p VESALNKsEPFLTWL
  mouse

 
S58 SFFKEPDSGsHsRQs
S60-p FKEPDSGsHsRQssT
S62-p EPDSGsHsRQssTDs
S65-p SGsHsRQssTDssGG
S66-p GsHsRQssTDssGGH
T67 sHsRQssTDssGGHP
S69-p sRQssTDssGGHPGP
S70-p RQssTDssGGHPGPR
S87 GGAQHVRSHssPAsL
S89-p AQHVRSHssPAsLQL
S90-p QHVRSHssPAsLQLG
S93-p RSHssPAsLQLGTGA
T98 PAsLQLGTGAGAAGG
G105 TGAGAAGGPAQQHAH
S117 HAHLRQQSYDVTDEL
S290 MRSVTNSSSDPFLNG
S306 PYHSREQSTDsGLGL
T307 YHSREQSTDsGLGLG
S309-p SREQSTDsGLGLGCy
Y316-p sGLGLGCySVPTTPE
S388 VESALNKSEPFLTWL
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