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Protein Page:
PLK4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PLK4 a kinase of the PLK family. Localizes to centrosomes and the cleavage furrow during cytokinesis. Interacts with the protein kinase Tec. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Other; Nucleolus; Kinase, protein; EC 2.7.11.21; Protein kinase, Ser/Thr (non-receptor); Other group; PLK family
Chromosomal Location of Human Ortholog: 4q28
Cellular Component: centriole; centrosome; nucleolus; cytosol; cleavage furrow
Molecular Function: protein serine/threonine kinase activity; identical protein binding; protein binding; protein-tyrosine kinase activity; ATP binding
Biological Process: peptidyl-tyrosine phosphorylation; positive regulation of centriole replication; centriole replication; mitotic cell cycle; G2/M transition of mitotic cell cycle; protein amino acid phosphorylation
Reference #:  O00444 (UniProtKB)
Alt. Names/Synonyms: PLK-4; PLK4; Polo-like kinase 4; polo-like kinase 4 (Drosophila); SAK; serine/threonine kinase 18; serine/threonine protein kinase SAK; Serine/threonine-protein kinase 18; Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase Sak; Snk akin kinase; STK18
Gene Symbols: PLK4
Molecular weight: 108,972 Da
Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PLK4

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
cell cycle regulation: S305‑p
intracellular localization: S305‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 1 S22-p GNLLGKGsFAGVYRA
1 2 T170-p MPHEKHYtLCGtPNy
0 1 T174-p KHYtLCGtPNyISPE
1 0 Y177-p tLCGtPNyISPEIAT
0 1 S255-p RNPADRLsLssVLDH
0 1 S257-p PADRLsLssVLDHPF
0 1 S258-p ADRLsLssVLDHPFM
0 1 S266-p VLDHPFMsRNSSTKS
1 0 S282 DLGTVEDSIDSGHAT
1 0 S285 TVEDSIDSGHATIST
1 0 T289 SIDSGHATISTAITA
1 0 S291 DSGHATISTAITASS
1 0 T292 SGHATISTAITASSS
1 0 A293 GHATISTAITASSST
1 0 T295 ATISTAITASSSTSI
1 0 S297 ISTAITASSSTSISG
1 0 S298 STAITASSSTSISGs
1 0 T300 AITASSSTSISGsLF
1 0 S301 ITASSSTSISGsLFD
1 0 S303 ASSSTSISGsLFDKR
2 0 S305-p SSTSISGsLFDKRRL
0 2 T323-p QPLPNKMtVFPKNKs
0 1 S330-p tVFPKNKsSTDFSSS
0 1 T345-p GDGNSFYtQWGNQET
0 1 Y377-p SRYLRRAysSDRSGT
0 1 S378-p RYLRRAysSDRSGTS
0 1 Y394-p SQSQAKTyTMERCHs
0 4 S401-p yTMERCHsAEMLsVS
0 1 S406-p CHsAEMLsVSKRSGG
0 1 Y420-p GGENEERysPTDNNA
0 4 S421-p GENEERysPTDNNAN
0 2 Y495-p HLRKTTEyDSIsPNR
0 1 S499-p TTEyDSIsPNRDFQG
0 1 K538-ac SDNAHSVkQQNTMKY
0 1 T547-p QNTMKYMtALHsKPE
0 1 S551-p KYMtALHsKPEIIQQ
0 2 G575 SEQSKTRGMEPPWGy
0 1 Y582-p GMEPPWGyQNRTLRS
0 1 T591-p NRTLRSItsPLVAHR
0 3 S592-p RTLRSItsPLVAHRL
0 2 S665-p PLADRPPsPTDNIsR
0 1 S671-p PsPTDNIsRYSFDNL
0 1 S749-p VIEKTGKsYtLKSES
0 3 T751-p EKTGKsYtLKSESEV
0 3 S817-p TSSPKALsPPPsVDS
0 1 S821-p KALsPPPsVDSNYPT
0 1 S833 YPTRERASFNRMVMH
  mouse

 
S22 GNLLGKGSFAGVYRA
T170 MPHEKHYTLCGTPNY
T174 KHYTLCGTPNYISPE
Y177 TLCGTPNYISPEIAT
S255 RNPADRLSLSSVLDH
S257 PADRLSLSSVLDHPF
S258 ADRLSLSSVLDHPFM
S266 VLDHPFMSRNPSPKS
S282-p DVGTVEDsMDsGHAt
S285-p TVEDsMDsGHAtLst
T289-p sMDsGHAtLsttItA
S291-p DsGHAtLsttItAss
T292-p sGHAtLsttItAssG
T293-p GHAtLsttItAssGt
T295-p AtLsttItAssGtsL
S297-p LsttItAssGtsLsG
S298-p sttItAssGtsLsGs
T300-p tItAssGtsLsGsLL
S301-p ItAssGtsLsGsLLD
S303-p AssGtsLsGsLLDRR
S305-p sGtsLsGsLLDRRLL
T322 QPLPNKITVFQKNKN
N329 TVFQKNKNSSDFSSG
T343 GDGSNFCTQWGNPEQ
H377 SRYLRRAHSSDRASP
S378 RYLRRAHSSDRASPS
Y393 NQSRAKTYSVERCHS
S400 YSVERCHSVEMLSKP
S405 CHSVEMLSKPRRSLD
- gap
- gap
H459 HLGETNEHHTVSPNR
S463 TNEHHTVSPNRDFQD
K501 SANVHAVKQLSAMKY
S510 LSAMKYMSAHHHKPE
H514 KYMSAHHHKPEVMPQ
S536-p SEQSKNRsMESTLGY
Y543 sMESTLGYQKPTLRS
T552 KPTLRSITSPLIAHR
S553 PTLRSITSPLIAHRL
L626 PLADRPPLPTDNISR
S632 PLPTDNISRYSFDNL
S710 IIEKTGISYNLKNEN
N712 EKTGISYNLKNENEV
S778 TSSPKALSAPPVDPS
- gap
S793-p CCKGEQAsASRLSVN
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