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TAB2
Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development. Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with NCOR1 and HDAC3 to form a ternary complex. Interacts (via C-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with WDR34 (via WD domains). Interacts with RBCK1. Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
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Cellular Component: plasma membrane; endosome membrane; cytosol
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Molecular Function: protein binding; zinc ion binding
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Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; activation of MAPK activity; heart development; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; Toll signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 2 signaling pathway; activation of NF-kappaB transcription factor; MyD88-dependent toll-like receptor signaling pathway; positive regulation of protein kinase activity; toll-like receptor signaling pathway; innate immune response; JNK cascade; toll-like receptor 4 signaling pathway
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Reference #:
Q9NYJ8 (UniProtKB)
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| Alt. Names/Synonyms: FLJ21885; KIAA0733; MAP3K7IP2; mitogen-activated protein kinase kinase kinase 7 interacting protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TAB-2; TAB2; TAK1-binding protein 2; TGF-beta activated kinase 1/MAP3K7 binding protein 2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; TGF-beta-activated kinase 1-binding protein 2 |
| Gene Symbols: TAB2 |
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Molecular weight: 76,494 Da
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Basal Isoelectric point: 8.8
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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Inhibition of Apoptosis
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NF-kB Signaling
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Toll-like Receptors Pathway
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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