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Protein Page:
IRF5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IRF5 Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. Homodimer, when phosphorylated. Belongs to the IRF family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: protein binding; transcription factor activity
Biological Process: transcription, DNA-dependent; positive regulation of interleukin-12 production; response to muramyl dipeptide; positive regulation of apoptosis; cytokine and chemokine mediated signaling pathway; response to peptidoglycan; positive regulation of interferon-beta production; positive regulation of transcription from RNA polymerase II promoter; defense response to virus; positive regulation of interferon-alpha production
Reference #:  Q13568 (UniProtKB)
Alt. Names/Synonyms: Interferon regulatory factor 5; IRF-5; IRF5; SLEB10
Gene Symbols: IRF5
Molecular weight: 56,044 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IRF5

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: S158‑p, S435‑p, S446‑p
transcription, induced: S435‑p, S437‑p, S440‑p, S446‑p
activity, induced: S435‑p, S437‑p, S440‑p
intracellular localization: S158‑p, S435‑p, S446‑p
molecular association, regulation: S440‑p, S446‑p
protein stabilization: S446‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 2 T10-p QSIPVAPtPPRRVRL
0 1 Y136-p DSQPPEDySFGAGEE
1 1 S158-p QRMLPSLsLTEDVKW
1 1 S293-p VELFGPIsLEQVRFP
1 1 S301-p LEQVRFPsPEDIPSD
0 3 K309-ub PEDIPSDkQRFYTNQ
0 2 Y335 QLQGQDLYAIRLCQC
1 0 K411-ub PDRKPREkkLITVQV
1 0 K412-ub DRKPREkkLITVQVV
3 1 S435-p EMFSGELsWsADsIR
2 0 S437-p FSGELsWsADsIRLQ
2 0 S440-p ELsWsADsIRLQIsN
2 1 S446-p DsIRLQIsNPDLKDR
  IRF5 iso2  
T10 QSIPVAPTPPRRVRL
Y136 DSQPPEDYSFGAGEE
S158 QRMLPSLSLTDAVQS
S309 VELFGPISLEQVRFP
S317 LEQVRFPSPEDIPSD
K325 PEDIPSDKQRFYTNQ
Y351 QLQGQDLYAIRLCQC
K427 PDRKPREKKLITVQV
K428 DRKPREKKLITVQVV
S451 EMFSGELSWSADSIR
S453 FSGELSWSADSIRLQ
S456 ELSWSADSIRLQISN
S462 DSIRLQISNPDLKDR
  mouse

 
P10 HSAPGIPPPPRRVRL
Y136 ESQPTDDYVLGEEEE
S157 QRMLPGLSITEPALP
T292 VELFGPVTLEQVRFP
S300 LEQVRFPSPEDIPSD
K308 PEDIPSDKQRFYTNQ
Y334-p QLQGQDLyAIRLCQC
K410 PDVKPREKKLITVQV
K411 DVKPREKKLITVQVV
S434 EMFSGELSWSADSIR
S436 FSGELSWSADSIRLQ
S439 ELSWSADSIRLQISN
S445 DSIRLQISNPDLKDH
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