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CCNH (human)

Overview CCNH Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor. Belongs to the cyclin family. Cyclin C subfamily. Note: This description may include information from UniProtKB. Protein type: Cell cycle regulation Cellular Component: nucleoplasm; holo TFIIH complex; nucleus; cyclin-dependent protein kinase activating kinase holoenzyme complex Molecular Function: RNA polymerase subunit kinase activity; DNA-dependent ATPase activity; protein binding; protein kinase binding; protein kinase activity Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; viral reproduction; positive regulation of viral transcription; RNA elongation from RNA polymerase I promoter; transcription from RNA polymerase I promoter; DNA repair; termination of RNA polymerase I transcription; protein amino acid phosphorylation; mRNA capping; nucleotide-excision repair; transcription-coupled nucleotide-excision repair; RNA elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; gene expression; nucleotide-excision repair, DNA damage removal; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; G2/M transition of mitotic cell cycle; S phase of mitotic cell cycle; G1 phase of mitotic cell cycle; transcription initiation from RNA polymerase I promoter; G1/S transition of mitotic cell cycle Reference #:  P51946 (UniProtKB) Alt. Names/Synonyms: CAK; CCNH; CDK-activating kinase; cyclin H; cyclin-dependent kinase-activating kinase; Cyclin-H; MO15-associated protein; p34; p37 Gene Symbols: CCNH Molecular weight: 37,643 Da Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states CST Pathways:  Protein Acetylation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CCNH 1JKW - A=1-323 (human) 1KXU - A=1-323 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1JKW 1KXU  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell growth, altered: S5‑p, S304‑p transcription, altered: S5‑p, S304‑p inhibition: S5‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	1		S5-p	___MYHNsSQKRHWT
0	1		S132-p	FVGNLREsPLGQEKA
0	1		K189	ENPEILRKTADDFLN
0	1		K261	SMRNLVKKyEPPRSE
0	2		Y262-p	MRNLVKKyEPPRSEE
0	1		Y297-p	ITKKRKGyEDDDyVs
0	10		Y302-p	KGyEDDDyVsKKsKH
1	1		S304-p	yEDDDyVsKKsKHEE
0	4		S307-p	DDyVsKKsKHEEEEW
1	69		T315-p	KHEEEEWtDDDLVEs
0	21		S322-p	tDDDLVEsL______

	mouse
S5-p	___MYHSsSQKRHWT
S132	FVGNLRESPLGQERA
K189-u	ENPEILRkTADDFLS
K261-a	SMRNLVKkYEPPRSD
Y262	MRNLVKkYEPPRSDE
Y297	VTKKRKGYEDDDYVS
Y302	KGYEDDDYVSKKPKQ
S304	YEDDDYVSKKPKQEE
P307	DDYVSKKPKQEEEEW
T315-p	KQEEEEWtDDDLVDS
S322	tDDDLVDSL______

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