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Protein Page:
CCNH (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CCNH Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor. Belongs to the cyclin family. Cyclin C subfamily. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Cellular Component: nucleoplasm; holo TFIIH complex; nucleolus; nucleus; cyclin-dependent protein kinase activating kinase holoenzyme complex
Molecular Function: RNA polymerase subunit kinase activity; DNA-dependent ATPase activity; protein binding; cyclin-dependent protein kinase regulator activity; protein kinase binding
Biological Process: ATP catabolic process; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; viral reproduction; positive regulation of viral transcription; transcription from RNA polymerase I promoter; RNA elongation from RNA polymerase I promoter; DNA repair; termination of RNA polymerase I transcription; protein amino acid phosphorylation; mRNA capping; nucleotide-excision repair; transcription-coupled nucleotide-excision repair; RNA elongation from RNA polymerase II promoter; gene expression; nucleotide-excision repair, DNA damage removal; positive regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; transcription initiation from RNA polymerase I promoter; G2/M transition of mitotic cell cycle; G1/S transition of mitotic cell cycle
Reference #:  P51946 (UniProtKB)
Alt. Names/Synonyms: CAK; CCNH; CDK-activating kinase; cyclin H; cyclin-dependent kinase-activating kinase; Cyclin-H; MO15-associated protein; p34; p37
Gene Symbols: CCNH
Molecular weight: 37,643 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CCNH

Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: S5‑p, S304‑p
transcription, altered: S5‑p, S304‑p
activity, inhibited: S5‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 1 S5-p ___MYHNsSQKRHWT
0 2 S132-p FVGNLREsPLGQEKA
0 1 K189 ENPEILRKTADDFLN
0 1 K261 SMRNLVKKyEPPRSE
0 1 Y262-p MRNLVKKyEPPRSEE
0 1 S282-p QKLERCHsAELALNV
0 1 Y297-p ITKKRKGyEDDDyVs
0 14 Y302-p KGyEDDDyVsKKsKH
1 1 S304-p yEDDDyVsKKsKHEE
0 5 S307-p DDyVsKKsKHEEEEW
1 67 T315-p KHEEEEWtDDDLVEs
0 17 S322-p tDDDLVEsL______
  mouse

 
S5-p ___MYHSsSQKRHWT
S132 FVGNLRESPLGQERA
K189-ub ENPEILRkTADDFLS
K261-ac SMRNLVKkYEPPRSD
Y262 MRNLVKkYEPPRSDE
S282 QKLERCHSSDLALNA
Y297 VTKKRKGYEDDDYVS
Y302 KGYEDDDYVSKKPKQ
S304 YEDDDYVSKKPKQEE
P307 DDYVSKKPKQEEEEW
T315-p KQEEEEWtDDDLVDS
S322 tDDDLVDSL______
  rat

 
S5 ___MYHNSSQKRHWT
S132 FVGNLRESPLGQEKA
K189 ENPEILRKTADDFLS
K261 SMRNLVKKYEPPRSE
Y262 MRNLVKKYEPPRSEE
S282 QKLERCHSSDLALNM
Y297 VTKKRKGYEDDDYVS
Y302 KGYEDDDYVSKKPKQ
S304 YEDDDYVSKKPKQEE
P307 DDYVSKKPKQEEEEW
T315-p KQEEEEWtDDDLVDA
A322 tDDDLVDAL______
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