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Protein Page:
DRAK2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DRAK2 a calmodulin-dependent kinase of the DAPK family. Interacts with and is regulated by calcineurin homologous protein (CHP), an EF-hand Ca(2+)-binding protein. In vitro, CHP inhibits the apoptosis-inducing protein kinase DRAK2 in the presence of elevated Ca(2+) levels. Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, CAMK; CAMK group; DAPK family
Cellular Component: plasma membrane; ER-Golgi intermediate compartment; nucleus; actin cytoskeleton
Molecular Function: protein serine/threonine kinase activity; ATP binding; protein kinase activity
Biological Process: apoptosis; protein amino acid autophosphorylation; protein amino acid phosphorylation
Reference #:  O94768 (UniProtKB)
Alt. Names/Synonyms: DAP kinase-related apoptosis-inducing protein kinase 2; death-associated protein kinase-related 2; DRAK2; serine/threonine kinase 17b; Serine/threonine-protein kinase 17B; ST17B; STK17B
Gene Symbols: STK17B
Molecular weight: 42,344 Da
Basal Isoelectric point: 5.13  Predict pI for various phosphorylation states
Select Structure to View Below

DRAK2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 3 S10-p RRRFDCRsIsGLLTT
1 2 S12-p RFDCRsIsGLLTTTP
0 3 K37-ub NFYILTSkELGRGKF
0 3 K53-ub VVRQCISkSTGQEYA
0 1 K65-ub EYAAKFLkKRRRGQD
0 1 K88-ub IAVLELAkSCPRVIN
0 3 K185-ub VDFGMSRkIGHACEL
1 0 S328 SEDKTSKSSCNGtCG
1 1 T333-p SKSSCNGtCGDREDK
1 1 S348 ENIPEDSSMVSKRFR
2 1 S351 PEDSSMVSKRFRFDD
1 2 N362 RFDDSLPNPHELVSD
  mouse

 
S10-p RRRFDCRsVsGLLTT
S12-p RFDCRsVsGLLTTTP
K37 NFYTLTPKELGRGKF
K53 VVRQCISKSTGQEYA
K65 EYAAKSLKKRRRGQD
R88 IAVLELARSCPHVIN
K185 VDFGMSRKIGNASEL
S328-p SEEKTSKsSCNGsCG
S333-p SKsSCNGsCGAREDK
S348-p ENIPEDGsLVsKRFR
S351-p PEDGsLVsKRFRFDD
S362-p RFDDSLPsPHELVPD
  rat

 
S10 RRRFDCRSISGLLTT
S12 RFDCRSISGLLTTTP
K37 NFYTLTPKELGRGKF
K53 VVRQCISKSTGQEYA
K65 EYAAKFLKKRRRGQD
R88 IAVLELARSCPHVIN
K185 VDFGMSRKIGNASEL
S328 SEDKTPKSCNGSCGD
S332 TPKSCNGSCGDREDK
S347 ENIPEDDSLLsKRFR
S350-p PEDDSLLsKRFRFDD
S361 RFDDSLPSPHELVPD
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