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CTMP (human)

Overview CTMP According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. Interacts with AKT1. Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation. Note: This description may include information from UniProtKB. Cellular Component: intracellular membrane-bound organelle; mitochondrion; mitochondrial inner membrane; plasma membrane; mitochondrial intermembrane space; cytosol Molecular Function: palmitoyl-CoA hydrolase activity Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; apoptosis; protein kinase B signaling cascade; insulin receptor signaling pathway; fatty acid metabolic process Reference #:  Q5T1C6 (UniProtKB) Alt. Names/Synonyms: C-terminal modulator protein; Carboxyl-terminal modulator protein; CTMP; MGC29636; THEM4; Thioesterase superfamily member 4 Gene Symbols: THEM4 Molecular weight: 27,130 Da Basal Isoelectric point: 8.58  Predict pI for various phosphorylation states CST Pathways:  PI3K/Akt Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CTMP 4AE8 - A/D/C/B=37-240 (human) 4GAH - A/B=1-201 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 4AE8 4GAH  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
intracellular localization: S37‑p, S38‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	1		S37-p	RPELRSFssEEVILK
1	1		S38-p	PELRSFssEEVILKD
0	17		K74-a	KCEDGSWkRLPSYkR
0	1		K74-u	KCEDGSWkRLPSYkR
0	1		K80-u	WkRLPSYkRTPTEWI
0	1		S192-p	KRPIPLCsVVMINsQ
0	1		S198-p	CsVVMINsQLDKVEG

	mouse
S28	GAARRLFSSEKVIRK
S29	AARRLFSSEKVIRKD
K65-a	KCEDGSWkRMPSHRQ
K65	KCEDGSWKRMPSHRQ
R71	WkRMPSHRQNPTRAI
S182	KKPIPLLSVVVVNSQ
S188	LSVVVVNSQLQKIEG

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