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Protein Page:
CTMP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CTMP According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. Interacts with AKT1. Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation. Note: This description may include information from UniProtKB.
Cellular Component: mitochondrion; mitochondrial inner membrane; plasma membrane; mitochondrial intermembrane space; cytosol
Molecular Function: palmitoyl-CoA hydrolase activity
Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; protein kinase B signaling cascade; insulin receptor signaling pathway; innate immune response; fatty acid metabolic process
Reference #:  Q5T1C6 (UniProtKB)
Alt. Names/Synonyms: C-terminal modulator protein; Carboxyl-terminal modulator protein; CTMP; MGC29636; THEM4; Thioesterase superfamily member 4
Gene Symbols: THEM4
Molecular weight: 27,130 Da
Basal Isoelectric point: 8.58  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CTMP

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S37‑p, S38‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 1 S37-p RPELRSFssEEVILK
1 1 S38-p PELRSFssEEVILKD
0 1 K55 VPNPSWNKDLRLLFD
0 17 K74 KCEDGSWKRLPSYkR
0 1 K74-ub KCEDGSWkRLPSYkR
0 1 K80-ub WkRLPSYkRTPTEWI
0 1 Q107 MKEEQMSQAQLFTRS
0 1 S192-p KRPIPLCsVVMINsQ
0 1 S198-p CsVVMINsQLDKVEG
  mouse

 
S28 GAARRLFSSEKVIRK
S29 AARRLFSSEKVIRKD
K46-ac LPNPSWTkDLRLLFD
K65-ac KCEDGSWkRMPSHRQ
K65 KCEDGSWKRMPSHRQ
R71 WkRMPSHRQNPTRAI
K98-ac KKEEQMSkAQQFTRS
S182 KKPIPLLSVVVVNSQ
S188 LSVVVVNSQLQKIEG
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