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Protein Page:
TRPC6 (human)

Overview
TRPC6 Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. Interacts with MX1 and RNF24. Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: integral to membrane; plasma membrane
Molecular Function: protein binding; store-operated calcium channel activity
Biological Process: positive regulation of ion transmembrane transporter activity; axon guidance; platelet activation; elevation of cytosolic calcium ion concentration; positive regulation of calcium ion transport; blood coagulation; transmembrane transport; cation transport; aging
Reference #:  Q9Y210 (UniProtKB)
Alt. Names/Synonyms: FLJ11098; FLJ14863; FSGS2; Short transient receptor potential channel 6; transient receptor potential cation channel, subfamily C, member 6; Transient receptor protein 6; TRP-6; TRP6; TRPC6
Gene Symbols: TRPC6
Molecular weight: 106,326 Da
Basal Isoelectric point: 6.24  Predict pI for various phosphorylation states
Select Structure to View Below

TRPC6

Protein Structure Not Found.


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Sites Implicated In
activity, inhibited: T70‑p, S322‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S13-p AFGPRRGssPRGAAG
1 3 S14-p FGPRRGssPRGAAGA
1 0 S28 AAARRNESQDyLLMD
1 2 Y31-p RRNESQDyLLMDSEL
10 8 T70-p RLAHRRQtVLREKGR
2 0 S282-p NAYKGLAsPAYLSLS
5 0 S322-p KNDYKKLsMQCKDFV
1 0 S449 KFVAHAASFTIFLGL
1 0 T488 KQLFRMKTSCFSWME
0 1 T759-p SYFEEGRtLPVPFNL
1 0 S769 VPFNLVPSPKSLFyL
0 1 Y775-p PSPKSLFyLLLKLKK
0 1 S785-p LKLKKWIsELFQGHK
0 1 L813 EEKKLGILGsHEDLS
1 5 S815-p KKLGILGsHEDLSKL
0 1 P835 QVGHNKQPSIRsSED
0 1 S836 VGHNKQPSIRsSEDF
0 1 S839-p NKQPSIRsSEDFHLN
  mouse

 
G13 RFVTRRGGsLKAAPG
S14-p FVTRRGGsLKAAPGA
S28-p AGTRRNEsQDYLLMD
Y31 RRNEsQDYLLMDELG
T69-p RLTHRRQtILREKGR
S281-p NAYKGLAsPAYLSLS
S321-p KNDYRKLsMQCKDFV
S448-p KFVAHAAsFTIFLGL
T487-p RQLFRMKtSCFSWME
T758 SYFEEGRTLPVPFNL
S768 VPFNLVPSPKSLLYL
Y774 PSPKSLLYLLLKFKK
C784 LKFKKWMCELIQGQK
S812-p EEKKFGIsGsHEDLS
S814-p KKFGIsGsHEDLSKF
S834-p QLAHNKQssTRSSED
S835-p LAHNKQssTRSSEDY
S838 NKQssTRSSEDYHLN
  rat

► Hide Isoforms
 
G13 GFVTRRGGSPKAAPG
S14 FVTRRGGSPKAAPGA
S28 AGARRNESQDYLLMD
Y31 RRNESQDYLLMDELG
T69-p RLTHRRQtVLREKGR
S281 NAYKGLASPAYLSLS
S321 KNDYRKLSMQCKDFV
S448 KFVAHAASFTIFLGL
T487 RQLFRMKTSCFSWME
T758 SYFEEGRTLPVPFNL
S768-p VPFNLVPsPKSLLYL
Y774 PsPKSLLYLLLKFKK
S784 LKFKKWMSELIQGHK
L812 EEKKFGILGSHEDLS
S814 KKFGILGSHEDLSKF
S834 QLAHNKQSSTRSSED
S835 LAHNKQSSTRSSEDF
S838 NKQSSTRSSEDFHLN
  TRPC6 iso2  
- gap
- gap
- gap
- gap
T15 RLTHRRQTVLREKGR
S227 NAYKGLASPAYLSLS
S267 KNDYRKLSMQCKDFV
S394 KFVAHAASFTIFLGL
T433 RQLFRMKTSCFSWME
T704 SYFEEGRTLPVPFNL
S714-p VPFNLVPsPKSLLYL
Y720 PsPKSLLYLLLKFKK
S730 LKFKKWMSELIQGHK
L758 EEKKFGILGSHEDLS
S760 KKFGILGSHEDLSKF
S780 QLAHNKQSSTRSSED
S781 LAHNKQSSTRSSEDF
S784 NKQSSTRSSEDFHLN
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