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Cdc42
a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. Causes the formation of thin, actin-rich surface projections called filopodia. The oncoprotein Dbl specifically catalyzes the dissociation of GDP from this protein. Regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Interacts with DOCK9 which activates it by exchanging GDP for GTP. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a complex with PARD3, PARD6A or PARD6B and PRKCI or PRKCZ. Interacts with CDC42EP4.Alternative splicing of this gene results in at least two transcript variants. Note: This description may include information from UniProtKB.
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| Protein type: G protein; G protein, monomeric (Rho); Motility/polarity/chemotaxis |
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Cellular Component: neuron projection; secretory granule; Golgi membrane; cell projection; cytoskeleton; membrane; cell soma; apical part of cell; cytoplasm; plasma membrane; spindle midzone; midbody; intracellular; filopodium
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Molecular Function: GTPase activity; identical protein binding; protein binding; GTP binding; GTP-dependent protein binding; thioesterase binding; nucleotide binding; mitogen-activated protein kinase kinase kinase binding; apolipoprotein A-I receptor binding; protein kinase binding
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Biological Process: regulation of protein heterodimerization activity; filopodium formation; regulation of protein metabolic process; establishment and/or maintenance of cell polarity; positive regulation of JNK cascade; regulation of protein stability; regulation of filopodium formation; Wnt receptor signaling pathway through beta-catenin; endosome transport; Rho protein signal transduction; cell-cell adhesion; positive regulation of MAPKKK cascade; establishment of Golgi localization; GTP catabolic process; small GTPase mediated signal transduction; positive regulation of neuron apoptosis; epidermis morphogenesis; keratinization; regulation of mitosis; cell differentiation; Golgi organization and biogenesis; neuron fate determination; nervous system development; actin filament bundle formation; regulation of attachment of spindle microtubules to kinetochore; hair follicle morphogenesis; multicellular organism growth; positive regulation of phosphoinositide 3-kinase activity; actin filament organization; establishment and/or maintenance of apical/basal cell polarity; positive regulation of metalloenzyme activity; nucleus localization; positive regulation of peptidyl-serine phosphorylation; positive regulation of synapse structural plasticity; positive regulation of pseudopodium formation; heart contraction; regulation of protein catabolic process; positive regulation of protein amino acid phosphorylation; sprouting angiogenesis; actin cytoskeleton organization and biogenesis; regulation of protein kinase activity; negative regulation of protein complex assembly; nuclear migration; positive regulation of DNA replication
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Reference #:
P60766 (UniProtKB)
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| Alt. Names/Synonyms: AI747189; AU018915; Cdc42; Cell division control protein 42 homolog; cell division cycle 42 homolog (S. cerevisiae); G25K GTP-binding protein; OTTMUSP00000010388 |
| Gene Symbols: Cdc42 |
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Molecular weight: 21,259 Da
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Basal Isoelectric point: 6.16
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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B Cell Receptor Signaling
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ErbB/HER Signaling
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Regulation of Actin Dynamics
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Regulation of Microtubule Dynamics
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SAPK/JNK Signaling Cascades
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T Cell Receptor Signaling
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TGF-ß Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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