a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. Causes the formation of thin, actin-rich surface projections called filopodia. The oncoprotein Dbl specifically catalyzes the dissociation of GDP from this protein. Regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Interacts with DOCK9 which activates it by exchanging GDP for GTP. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a complex with PARD3, PARD6A or PARD6B and PRKCI or PRKCZ. Interacts with CDC42EP4.Alternative splicing of this gene results in at least two transcript variants. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric (Rho); Motility/polarity/chemotaxis
Molecular Function: GTPase activity; identical protein binding; protein binding; GTP binding; GTP-dependent protein binding; thioesterase binding; nucleotide binding; mitogen-activated protein kinase kinase kinase binding; apolipoprotein A-I receptor binding; protein kinase binding
Biological Process: regulation of protein heterodimerization activity; filopodium formation; regulation of protein metabolic process; establishment and/or maintenance of cell polarity; positive regulation of JNK cascade; regulation of protein stability; regulation of filopodium formation; Wnt receptor signaling pathway through beta-catenin; endosome transport; Rho protein signal transduction; cell-cell adhesion; positive regulation of MAPKKK cascade; establishment of Golgi localization; GTP catabolic process; small GTPase mediated signal transduction; positive regulation of neuron apoptosis; epidermis morphogenesis; keratinization; regulation of mitosis; cell differentiation; Golgi organization and biogenesis; neuron fate determination; nervous system development; actin filament bundle formation; regulation of attachment of spindle microtubules to kinetochore; hair follicle morphogenesis; multicellular organism growth; positive regulation of phosphoinositide 3-kinase activity; actin filament organization; establishment and/or maintenance of apical/basal cell polarity; positive regulation of metalloenzyme activity; nucleus localization; positive regulation of peptidyl-serine phosphorylation; positive regulation of synapse structural plasticity; positive regulation of pseudopodium formation; heart contraction; regulation of protein catabolic process; positive regulation of protein amino acid phosphorylation; sprouting angiogenesis; actin cytoskeleton organization and biogenesis; regulation of protein kinase activity; negative regulation of protein complex assembly; nuclear migration; positive regulation of DNA replication
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.