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Cdc16 (human)

Overview Cdc16 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C is composed of at least 12 subunits. Interacts with PPP5C and CDC20. Belongs to the APC6/CDC16 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Cellular Component: nucleoplasm; centrosome; anaphase-promoting complex; spindle microtubule; cytoplasm; spindle; cytosol Molecular Function: protein binding Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell proliferation; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle spindle assembly checkpoint; regulation of mitosis; mitotic cell cycle; cell cycle checkpoint Reference #:  Q13042 (UniProtKB) Alt. Names/Synonyms: ANAPC6; Anaphase-promoting complex subunit 6; anaphase-promoting complex, subunit 6; APC6; CDC16; CDC16 homolog; CDC16Hs; cell division cycle 16 homolog (S. cerevisiae); Cell division cycle protein 16 homolog; Cyclosome subunit 6 Gene Symbols: CDC16 Molecular weight: 71,656 Da Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Cdc16 3HYM - H/F/J/D/L/B=212-539 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K106-u	INKRLFEkYLKDEsG
0	2		S112-p	EkYLKDEsGFkDPSS
0	1		K115-u	LKDEsGFkDPSSDWE
0	1		K154-u	TLATYSYkEALKLDV
0	3		K192	LESLPLSKLCNEEQE
0	1		T254-p	FKMCYKLtSVVMEKD
0	1		K423-u	GEWKTAEkWFLDALE
0	1		K431	WFLDALEKIKAIGNE
0	1		S490-p	SAIGYIHsLMGNFEN
0	1		Y501	NFENAVDYFHTALGL
0	1		T504	NAVDYFHTALGLRRD
0	1		K543	ADIKDKLKCYDFDVH
0	1		K553	DFDVHTMKTLkNIIs
0	2		K556-u	VHTMKTLkNIIsPPW
1	24		S560-p	KTLkNIIsPPWDFRE
0	1		K572-u	FREFEVEkQTAEETG
0	11		T581-p	TAEETGLtPLETsRK
0	2		S586-p	GLtPLETsRKtPDSR
0	1		T589-p	PLETsRKtPDSRPsL
0	1		S595-p	KtPDSRPsLEEtFEI
0	1		T599-p	SRPsLEEtFEIEMNE
0	1		S607-p	FEIEMNEsDMMLETs
0	1		S614-p	sDMMLETsMSDHST_

	mouse
K106	INRRLFEKYLKDDNG
N112	EKYLKDDNGSRDPSS
R115	LKDDNGSRDPSSDWE
K154	TLATYSYKEALKLDV
K192-u	LDSLPLNkLCAEEQE
T254	FKMCYKLTSTVMEKD
K423	GEWKTAEKWFLDALE
K431-u	WFLDALEkIKAIGNE
S490	SAIGYIHSLMGNFEN
Y501-p	NFENAVDyFHtALGL
T504-p	NAVDyFHtALGLRRD
K543-u	ADIKDKLkCYDFDVH
K553-u	DFDVHTMkTLKNIIs
K556	VHTMkTLKNIIsPPW
S560-p	kTLKNIIsPPWDFRD
K572	FRDFEVEKQNTEEAG
A581	NTEEAGLAPLQNSTK
S586	GLAPLQNSTKAPESR
A589	PLQNSTKAPESRPNL
N595	KAPESRPNLEETFEI
T599	SRPNLEETFEIEMNE
S607	FEIEMNESDMMLETS
S614	SDMMLETSMSDHST_

	rat
K106	INRRLFEKYLKDDSG
S112	EKYLKDDSGSKDPSS
K115	LKDDSGSKDPSSDWE
K154	TLATYSYKEALKLDV
K192	LDSLPLSKLCAEEQE
T254	FKMCYKLTSAVMEKD
K423	GEWKTAEKWFLDALE
K431	WFLDALEKIKAIGNE
S490	SAIGYIHSLMGNFEN
Y501	NFENAVDYFHTALGL
T504	NAVDYFHTALGLRRD
K543	ADIKDKLKCYDFDVH
K553	DFDVHTMKTLKNIIS
K556	VHTMKTLKNIISPPW
S560	KTLKNIISPPWDFRD
K572	FRDFEVEKQNTEEAG
A581	NTEEAGLAPLENATK
A586	GLAPLENATKTPESR
T589	PLENATKTPESRPSL
S595	KTPESRPSLEETFEI
T599	SRPSLEETFEIEMNE
S607	FEIEMNESDMMLETS
S614	SDMMLETSMSDHST_

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