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Protein Page:
Cdc16 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Cdc16 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C is composed of at least 12 subunits. Interacts with PPP5C and CDC20. Belongs to the APC6/CDC16 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Cellular Component: nucleoplasm; centrosome; anaphase-promoting complex; spindle microtubule; cytoplasm; spindle; cytosol
Molecular Function: protein binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; cell proliferation; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle spindle assembly checkpoint; regulation of mitosis; mitotic cell cycle
Reference #:  Q13042 (UniProtKB)
Alt. Names/Synonyms: ANAPC6; Anaphase-promoting complex subunit 6; anaphase-promoting complex, subunit 6; APC6; CDC16; CDC16 homolog; CDC16Hs; cell division cycle 16 homolog (S. cerevisiae); Cell division cycle protein 16 homolog; Cyclosome subunit 6
Gene Symbols: CDC16
Molecular weight: 71,656 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Cdc16

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T50-p LAQCLYLtAQyHRAA
0 1 Y53-p CLYLtAQyHRAAHAL
0 1 K106-ub INKRLFEkYLKDEsG
0 3 S112-p EkYLKDEsGFkDPSS
0 1 K115-ub LKDEsGFkDPSSDWE
0 1 K154-ub TLATYSYkEALKLDV
0 3 K192 LESLPLSKLCNEEQE
0 1 T254-p FKMCYKLtSVVMEKD
0 1 S324-p EHARRYLsKAttLEK
0 1 T327-p RRYLsKAttLEKTYG
0 1 T328-p RYLsKAttLEKTYGP
0 1 K423-ub GEWKTAEkWFLDALE
0 1 K431 WFLDALEKIKAIGNE
0 1 T440-p KAIGNEVtVDKWEPL
0 1 S490-p SAIGYIHsLMGNFEN
0 1 Y501 NFENAVDYFHTALGL
0 1 T504 NAVDYFHTALGLRRD
0 1 K543 ADIKDKLKCYDFDVH
0 1 K553 DFDVHTMKTLkNIIs
0 2 K556-ub VHTMKTLkNIIsPPW
1 28 S560-p KTLkNIIsPPWDFRE
0 1 K572-ub FREFEVEkQTAEETG
0 13 T581-p TAEETGLtPLETsRK
0 4 S586-p GLtPLETsRKtPDSR
0 1 T589-p PLETsRKtPDSRPsL
0 1 S595-p KtPDSRPsLEEtFEI
0 1 T599-p SRPsLEEtFEIEMNE
0 1 S607-p FEIEMNEsDMMLETs
0 1 S614-p sDMMLETsMSDHST_
  mouse

 
T50 LAQCLYLTAQYHRAA
Y53 CLYLTAQYHRAAHAL
K106 INRRLFEKYLKDDNG
N112 EKYLKDDNGSRDPSS
R115 LKDDNGSRDPSSDWE
K154 TLATYSYKEALKLDV
K192-ub LDSLPLNkLCAEEQE
T254 FKMCYKLTSTVMEKD
S324 EHARRYLSKATTLEK
T327 RRYLSKATTLEKTYG
T328 RYLSKATTLEKTYGP
K423 GEWKTAEKWFLDALE
K431-ub WFLDALEkIKAIGNE
T440 KAIGNEVTVDKWEPL
S490 SAIGYIHSLMGNFEN
Y501-p NFENAVDyFHtALGL
T504-p NAVDyFHtALGLRRD
K543-ub ADIKDKLkCYDFDVH
K553-ub DFDVHTMkTLKNIIs
K556 VHTMkTLKNIIsPPW
S560-p kTLKNIIsPPWDFRD
K572 FRDFEVEKQNTEEAG
A581 NTEEAGLAPLQNSTK
S586 GLAPLQNSTKAPESR
A589 PLQNSTKAPESRPNL
N595 KAPESRPNLEETFEI
T599 SRPNLEETFEIEMNE
S607 FEIEMNESDMMLETS
S614 SDMMLETSMSDHST_
  rat

 
T50 LAQCLYLTAQYHRAA
Y53 CLYLTAQYHRAAHAL
K106 INRRLFEKYLKDDSG
S112 EKYLKDDSGSKDPSS
K115 LKDDSGSKDPSSDWE
K154 TLATYSYKEALKLDV
K192 LDSLPLSKLCAEEQE
T254 FKMCYKLTSAVMEKD
S324 EHARRYLSKATTLEK
T327 RRYLSKATTLEKTYG
T328 RYLSKATTLEKTYGP
K423 GEWKTAEKWFLDALE
K431 WFLDALEKIKAIGNE
T440 KAIGNEVTVDKWEPL
S490 SAIGYIHSLMGNFEN
Y501 NFENAVDYFHTALGL
T504 NAVDYFHTALGLRRD
K543 ADIKDKLKCYDFDVH
K553 DFDVHTMKTLKNIIS
K556 VHTMKTLKNIISPPW
S560 KTLKNIISPPWDFRD
K572 FRDFEVEKQNTEEAG
A581 NTEEAGLAPLENATK
A586 GLAPLENATKTPESR
T589 PLENATKTPESRPSL
S595 KTPESRPSLEETFEI
T599 SRPSLEETFEIEMNE
S607 FEIEMNESDMMLETS
S614 SDMMLETSMSDHST_
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