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APC2 (human)

Overview APC2 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the cullin family. The APC/C is composed of at least 12 subunits. Interacts through the cullin domain with ANAPC11 and with UBCH10. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Ubiquitin conjugating system; Motility/polarity/chemotaxis Cellular Component: nucleoplasm; anaphase-promoting complex; cytosol Molecular Function: ubiquitin protein ligase binding; ubiquitin-protein ligase activity Biological Process: ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of axon extension; positive regulation of synaptic plasticity; positive regulation of dendrite morphogenesis; cyclin catabolic process; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle spindle assembly checkpoint; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; cell cycle checkpoint Reference #:  Q9UJX6 (UniProtKB) Alt. Names/Synonyms: ANAPC2; anaphase promoting complex subunit 2; Anaphase-promoting complex subunit 2; ANC2; APC2; Cyclosome subunit 2; KIAA1406; RP11-350O14.5 Gene Symbols: ANAPC2 Molecular weight: 93,828 Da Basal Isoelectric point: 5.12  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below APC2

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K134-u	RSLELLEkWTRLGLL
0	2		K190-u	VYMQSKRkGEGGTDP
0	8		S218-p	RYYRLLQsPLCAGCS
0	11		S314-p	DGPARPAsPEAGNTL
0	1		T320	AsPEAGNTLRRWRCH
0	1		S346-p	LRIEELFsIVRDFPD
0	1		S354-p	IVRDFPDsRPAIEDL
0	1		S377-p	QRQQLLVsLKAALET
0	1		T393-p	LLHPGVNtCDIITLY
0	3		T443-p	RQIVAGLtGDSDGTG
0	7		S470-p	SLETGQDsEDDsGEP
0	2		S474-p	GQDsEDDsGEPEDWV
0	1		S492-p	VDADPGKsSSKRRsS
0	1		S498-p	KsSSKRRsSDIISLL
0	4		S507-p	DIISLLVsIyGsKDL
0	1		Y509-p	ISLLVsIyGsKDLFI
0	3		S511-p	LLVsIyGsKDLFINE
0	2		S532-p	DRLLHQFsFsPEREI
0	12		S534-p	LLHQFsFsPEREIRN
0	1		K546	IRNVELLKLRFGEAP
0	1		S697	ALLRRRMSVWLQQGV
0	1		R720-m2	FSVIEEErPQDRDNM
0	3		S732-p	DNMVLIDsDDEsDSG
0	3		S736-p	LIDsDDEsDSGMASQ
0	17		Y810-p	VRDQQLVysAGVYRL
0	1		S811-p	RDQQLVysAGVYRLP

	mouse
K149	HSLELLEKWTRLGLL
K205-u	VYMQSKRkGEGGTDP
S233	RYYRLLQSPLCAGCG
S329-p	DNPTRPTsPEAGNtL
T335-p	TsPEAGNtLRRWRCH
S361	LRIEELFSIIRDFPD
S369	IIRDFPDSRPAIEDL
S392	QRQQLLVSLKVALET
T408	LLHPGVNTCDIITLY
T458	RQIVAGLTGDSDGTG
S485-p	CLETGQDsEDDsGEP
S489-p	GQDsEDDsGEPEDWV
S507	VDADPVKSSSKRRSS
S513	KSSSKRRSSDIISLL
S522-p	DIISLLVsIYGSKDL
Y524	ISLLVsIYGSKDLFI
S526	LLVsIYGSKDLFINE
S547	DRLLHQFSFsPEREI
S549-p	LLHQFSFsPEREIRN
K561-u	IRNVELLkLRFGEAP
S712-p	ALLRRRMsVWLQQGV
R735	FSVIEEERPQDRDNM
S747-p	DNMVLIDsDDEsDSG
S751-p	LIDsDDEsDSGMASQ
Y825-p	VRDQQLIySAGVYRL
S826	RDQQLIySAGVYRLP

	rat
-	under review
-	under review
-	gap
S31	DNPSRPTSPEAGNTL
T37	TSPEAGNTLRRWRCH
S63	LRIEELFSIIRDFPD
S71	IIRDFPDSRPAIEDL
S94	QRQQLLVSLKVALET
T110	LLHPGVNTCDIITLY
T160	RQIVAGLTGDSDGTG
S187	CLETGQDSEDDSGEP
S191	GQDSEDDSGEPEDWV
S209	VDADPAKSSSKRRSS
S215	KSSSKRRSSDIISLL
S224	DIISLLVSIYGSKDL
Y226	ISLLVSIYGSKDLFI
S228	LLVSIYGSKDLFINE
S249	DRLLHQFSFSPEREI
S251	LLHQFSFSPEREIRN
K263	IRNVELLKLRFGEAP
S414	ALLRRRMSVWLQQGV
R437	FSVIEEERPQDRDNM
S449	DNMVLIDSDDESDSG
S453	LIDSDDESDSGMASQ
Y527-p	VRDQQLIySAGVYRL
S528	RDQQLIySAGVYRLP

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