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Protein Page:
APC2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
APC2 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the cullin family. The APC/C is composed of at least 12 subunits. Interacts through the cullin domain with ANAPC11 and with UBCH10. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Ubiquitin conjugating system
Cellular Component: nucleoplasm; anaphase-promoting complex; cytosol
Molecular Function: ubiquitin protein ligase binding; ubiquitin-protein ligase activity
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; ubiquitin-dependent protein catabolic process; cyclin catabolic process; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of axon extension; mitotic cell cycle spindle assembly checkpoint; positive regulation of synaptic plasticity; regulation of cyclin-dependent protein kinase activity; positive regulation of dendrite morphogenesis; mitotic cell cycle
Reference #:  Q9UJX6 (UniProtKB)
Alt. Names/Synonyms: ANAPC2; anaphase promoting complex subunit 2; Anaphase-promoting complex subunit 2; ANC2; APC2; Cyclosome subunit 2; KIAA1406; RP11-350O14.5
Gene Symbols: ANAPC2
Molecular weight: 93,828 Da
Basal Isoelectric point: 5.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

APC2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K134-ub RSLELLEkWTRLGLL
0 2 K190-ub VYMQSKRkGEGGTDP
0 10 S218-p RYYRLLQsPLCAGCS
0 14 S314-p DGPARPAsPEAGNTL
0 1 T320 AsPEAGNTLRRWRCH
0 1 S346-p LRIEELFsIVRDFPD
0 2 S354-p IVRDFPDsRPAIEDL
0 1 S377-p QRQQLLVsLKAALET
0 1 T393-p LLHPGVNtCDIITLY
0 3 T443-p RQIVAGLtGDSDGTG
0 2 T466-p TDPASLEtGQDsEDD
0 9 S470-p SLEtGQDsEDDsGEP
0 4 S474-p GQDsEDDsGEPEDWV
0 1 S492-p VDADPGKsSSKRRsS
0 1 S498-p KsSSKRRsSDIISLL
0 4 S507-p DIISLLVsIyGsKDL
0 1 Y509-p ISLLVsIyGsKDLFI
0 3 S511-p LLVsIyGsKDLFINE
0 2 S532-p DRLLHQFsFsPEREI
0 16 S534-p LLHQFsFsPEREIRN
0 1 K546 IRNVELLKLRFGEAP
0 1 S697 ALLRRRMSVWLQQGV
0 1 R720-m2 FSVIEEErPQDRDNM
0 4 S732-p DNMVLIDsDDEsDSG
0 4 S736-p LIDsDDEsDSGMASQ
0 17 Y810-p VRDQQLVysAGVYRL
0 1 S811-p RDQQLVysAGVYRLP
  APC2 iso2  
K134 RSLELLEKWTRLGLL
K190 VYMQSKRKGEGGTDP
S218 RYYRLLQSPLCAGCS
S314 DGPARPASPEAGNTL
T320 ASPEAGNTLRRWRCH
S346 LRIEELFSIVRDsRP
S351-p LFSIVRDsRPAIEDL
S374 QRQQLLVSLKAALET
T390 LLHPGVNTCDIITLY
T440 RQIVAGLTGDSDGTG
T463 TDPASLETGQDSEDD
S467 SLETGQDSEDDSGEP
S471 GQDSEDDSGEPEDWV
S489 VDADPGKSSSKRRSS
S495 KSSSKRRSSDIISLL
S504 DIISLLVSIYGSKDL
Y506 ISLLVSIYGSKDLFI
S508 LLVSIYGSKDLFINE
S529 DRLLHQFSFSPEREI
S531 LLHQFSFSPEREIRN
K543 IRNVELLKLRFGEAP
S694 ALLRRRMSVWLQQGV
R717 FSVIEEERPQDRDNM
S729 DNMVLIDSDDESDSG
S733 LIDSDDESDSGMASQ
Y807 VRDQQLVYSAGVYRL
S808 RDQQLVYSAGVYRLP
  mouse

 
K149 HSLELLEKWTRLGLL
K205-ub VYMQSKRkGEGGTDP
S233 RYYRLLQSPLCAGCG
S329-p DNPTRPTsPEAGNtL
T335-p TsPEAGNtLRRWRCH
S361 LRIEELFSIIRDFPD
S369 IIRDFPDSRPAIEDL
S392 QRQQLLVSLKVALET
T408 LLHPGVNTCDIITLY
T458 RQIVAGLTGDSDGTG
T481 TDPACLETGQDsEDD
S485-p CLETGQDsEDDsGEP
S489-p GQDsEDDsGEPEDWV
S507 VDADPVKSSSKRRSS
S513 KSSSKRRSSDIISLL
S522-p DIISLLVsIYGSKDL
Y524 ISLLVsIYGSKDLFI
S526 LLVsIYGSKDLFINE
S547 DRLLHQFSFsPEREI
S549-p LLHQFSFsPEREIRN
K561-ub IRNVELLkLRFGEAP
S712-p ALLRRRMsVWLQQGV
R735 FSVIEEERPQDRDNM
S747-p DNMVLIDsDDEsDSG
S751-p LIDsDDEsDSGMASQ
Y825-p VRDQQLIySAGVYRL
S826 RDQQLIySAGVYRLP
  rat

 
- gap
- gap
- gap
S31 DNPSRPTSPEAGNTL
T37 TSPEAGNTLRRWRCH
S63 LRIEELFSIIRDFPD
S71 IIRDFPDSRPAIEDL
S94 QRQQLLVSLKVALET
T110 LLHPGVNTCDIITLY
T160 RQIVAGLTGDSDGTG
T183 TDPACLETGQDSEDD
S187 CLETGQDSEDDSGEP
S191 GQDSEDDSGEPEDWV
S209 VDADPAKSSSKRRSS
S215 KSSSKRRSSDIISLL
S224 DIISLLVSIYGSKDL
Y226 ISLLVSIYGSKDLFI
S228 LLVSIYGSKDLFINE
S249 DRLLHQFSFSPEREI
S251 LLHQFSFSPEREIRN
K263 IRNVELLKLRFGEAP
S414 ALLRRRMSVWLQQGV
R437 FSVIEEERPQDRDNM
S449-p DNMVLIDsDDEsDSG
S453-p LIDsDDEsDSGMASQ
Y527-p VRDQQLIySAGVYRL
S528 RDQQLIySAGVYRLP
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