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Protein Page:
APC2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
APC2 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the cullin family. The APC/C is composed of at least 12 subunits. Interacts through the cullin domain with ANAPC11 and with UBCH10. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Ubiquitin conjugating system
Cellular Component: nucleoplasm; anaphase-promoting complex; cytosol
Molecular Function: ubiquitin protein ligase binding; ubiquitin-protein ligase activity
Biological Process: ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of axon extension; positive regulation of synaptic plasticity; positive regulation of dendrite morphogenesis; cyclin catabolic process; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle; regulation of cyclin-dependent protein kinase activity
Reference #:  Q9UJX6 (UniProtKB)
Alt. Names/Synonyms: ANAPC2; anaphase promoting complex subunit 2; Anaphase-promoting complex subunit 2; ANC2; APC2; Cyclosome subunit 2; KIAA1406; RP11-350O14.5
Gene Symbols: ANAPC2
Molecular weight: 93,828 Da
Basal Isoelectric point: 5.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

APC2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K134-u RSLELLEkWTRLGLL
0 2 K190-u VYMQSKRkGEGGTDP
0 9 S218-p RYYRLLQsPLCAGCS
0 12 S314-p DGPARPAsPEAGNTL
0 1 S346-p LRIEELFsIVRDFPD
0 1 S354-p IVRDFPDsRPAIEDL
0 1 T393-p LLHPGVNtCDIITLY
0 3 T443-p RQIVAGLtGDSDGTG
0 7 S470-p SLETGQDsEDDsGEP
0 2 S474-p GQDsEDDsGEPEDWV
0 4 S507-p DIISLLVsIyGsKDL
0 1 Y509-p ISLLVsIyGsKDLFI
0 3 S511-p LLVsIyGsKDLFINE
0 3 S532-p DRLLHQFsFsPEREI
0 14 S534-p LLHQFsFsPEREIRN
0 1 K546 IRNVELLKLRFGEAP
0 1 S697 ALLRRRMSVWLQQGV
0 4 S732-p DNMVLIDsDDEsDSG
0 4 S736-p LIDsDDEsDSGMASQ
0 17 Y810-p VRDQQLVySAGVYRL
  mouse

 
K149 HSLELLEKWTRLGLL
K205-u VYMQSKRkGEGGTDP
S233 RYYRLLQSPLCAGCG
S329-p DNPTRPTsPEAGNTL
S361 LRIEELFSIIRDFPD
S369 IIRDFPDSRPAIEDL
T408 LLHPGVNTCDIITLY
T458 RQIVAGLTGDSDGTG
S485-p CLETGQDsEDDsGEP
S489-p GQDsEDDsGEPEDWV
S522-p DIISLLVsIYGSKDL
Y524 ISLLVsIYGSKDLFI
S526 LLVsIYGSKDLFINE
S547 DRLLHQFSFsPEREI
S549-p LLHQFSFsPEREIRN
K561-u IRNVELLkLRFGEAP
S712-p ALLRRRMsVWLQQGV
S747-p DNMVLIDsDDEsDSG
S751-p LIDsDDEsDSGMASQ
Y825-p VRDQQLIySAGVYRL
  rat

 
- under review  
- under review  
- gap
S31 DNPSRPTSPEAGNTL
S63 LRIEELFSIIRDFPD
S71 IIRDFPDSRPAIEDL
T110 LLHPGVNTCDIITLY
T160 RQIVAGLTGDSDGTG
S187 CLETGQDSEDDSGEP
S191 GQDSEDDSGEPEDWV
S224 DIISLLVSIYGSKDL
Y226 ISLLVSIYGSKDLFI
S228 LLVSIYGSKDLFINE
S249 DRLLHQFSFSPEREI
S251 LLHQFSFSPEREIRN
K263 IRNVELLKLRFGEAP
S414 ALLRRRMSVWLQQGV
S449-p DNMVLIDsDDEsDSG
S453-p LIDsDDEsDSGMASQ
Y527-p VRDQQLIySAGVYRL
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