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Overview |
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NRIF3
Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF- kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A- associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Homodimer; mediated by the coiled coil domain. Isoform 3, but not other isoforms, interacts with the cytoplasmic tail of integrin ITGB3. The relevance of the interaction with ITGB3 is however uncertain, since isoform 3 is mainly nuclear. Interacts with CCNA2 and MTA1. Interacts with NFKB1 NF-kappa-B subunit. Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. By estrogen. Widely expressed. Expressed in spleen, thymus, prostate, ovary, small intestine and white blood cells. Highly expressed in testis and colon. Isoform 4 is expressed in platelets, lymphocytes and granulocytes. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Transcription, coactivator/corepressor; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator |
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Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; cytosol; nucleus
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Molecular Function: protein C-terminus binding; signal transducer activity
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Biological Process: nucleosome assembly; M phase of mitotic cell cycle; DNA replication-independent nucleosome assembly at centromere; regulation of transcription, DNA-dependent; transcription, DNA-dependent; nerve growth factor receptor signaling pathway; apoptosis; cell division; mitotic cell cycle; cell adhesion; signal transduction; mitotic prometaphase
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Reference #:
Q13352 (UniProtKB)
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| Alt. Names/Synonyms: beta 3 endonexin; Beta-3-endonexin; CENP-R; CENPR; Centromere protein R; HSU37139; integrin beta 3 binding protein; integrin beta 3 binding protein (beta3-endonexin); Integrin beta-3-binding protein; ITGB3BP; NRIF3; Nuclear receptor-interacting factor 3; TAP20 |
| Gene Symbols: ITGB3BP |
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Molecular weight: 20,194 Da
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Basal Isoelectric point: 9.13
Predict pI for various phosphorylation states
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Select Structure to View Below |
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NRIF3 |
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