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Protein Page:
NRIF3 (human)

Overview
NRIF3 Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF- kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A- associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Homodimer; mediated by the coiled coil domain. Isoform 3, but not other isoforms, interacts with the cytoplasmic tail of integrin ITGB3. The relevance of the interaction with ITGB3 is however uncertain, since isoform 3 is mainly nuclear. Interacts with CCNA2 and MTA1. Interacts with NFKB1 NF-kappa-B subunit. Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. By estrogen. Widely expressed. Expressed in spleen, thymus, prostate, ovary, small intestine and white blood cells. Highly expressed in testis and colon. Isoform 4 is expressed in platelets, lymphocytes and granulocytes. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; Cell adhesion; Nuclear receptor co-regulator; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1p31.3
Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; cytosol; nucleus
Molecular Function: protein C-terminus binding; signal transducer activity
Biological Process: nucleosome assembly; mitosis; DNA replication-independent nucleosome assembly at centromere; nerve growth factor receptor signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of apoptosis; mitotic cell cycle; cell adhesion; signal transduction
Reference #:  Q13352 (UniProtKB)
Alt. Names/Synonyms: beta 3 endonexin; Beta-3-endonexin; CENP-R; CENPR; Centromere protein R; HSU37139; integrin beta 3 binding protein; integrin beta 3 binding protein (beta3-endonexin); Integrin beta-3-binding protein; ITGB3BP; NRIF3; Nuclear receptor-interacting factor 3; TAP20
Gene Symbols: ITGB3BP
Molecular weight: 20,194 Da
Basal Isoelectric point: 9.13  Predict pI for various phosphorylation states
Select Structure to View Below

NRIF3

Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: S28‑p
transcription, induced: S28‑p
activity, induced: S28‑p
molecular association, regulation: S28‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S6-p __MPVKRsLKLDGLL
0 7 S17-p DGLLEENsFDPSKIT
2 1 S28-p SKITRKKsVITysPT
0 1 I30 ITRKKsVITysPTTG
0 1 Y32-p RKKsVITysPTTGTC
1 1 S33-p KKsVITysPTTGTCQ
0 1 T35 sVITysPTTGTCQMS
0 1 T36 VITysPTTGTCQMSL
0 1 T38 TysPTTGTCQMSLFA
1 0 S46-p CQMSLFAsPTSSEEQ
0 7 S71-p RKKLNHPsLtESKES
0 1 L72 KKLNHPsLtESKEST
0 2 T73-p KLNHPsLtESKESTT
0 1 S168-p KASRHLDsYEFLKAI
  mouse

 
S6 __MPVKRSLKLDDQF
S17 DDQFEKNSFSPSKIV
S28 SKIVRKKSItAYsPt
T30-p IVRKKSItAYsPttG
Y32 RKKSItAYsPttGtY
S33-p KKSItAYsPttGtYQ
T35-p SItAYsPttGtYQLS
T36-p ItAYsPttGtYQLSP
T38-p AYsPttGtYQLSPFS
S46 YQLSPFSSPATPKEQ
S71-p RKRSNLSsPVRQEST
- under review  
- gap
S167 PKDHHLDSFEFLKAI
  rat

 
S6 __MPVKRSLKLDDQF
S17 DDQFEENSFGPSKIM
S28-p SKIMRKKsITAFSPT
T30 IMRKKsITAFSPTTG
F32 RKKsITAFSPTTGTY
S33 KKsITAFSPTTGTYQ
T35 sITAFSPTTGTYQLS
- under review  
T38 AFSPTTGTYQLSPFS
S46 YQLSPFSSPRTPKEQ
S70 TRKWSVLSsPARQDS
S71-p RKWSVLSsPARQDST
- under review  
S167 PKEHHPNSFEFLKAI
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