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ARNT (human)

Overview ARNT a bHLH transcription factor that requires dimerization with another bHLH protein for efficient DNA binding. A binding partner for the Ah (dioxin) nuclear receptor. Required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. A binding partner for HIF1A or HIF2A, transcription factors that regulates transcription from RNA polymerase II promoter in the adaptive response to hypoxia and oxidative stress. This complex activates target genes that limit oxygen consumption. HIF-1alpha may have nontranscriptional activities that inhibit DNA replication and cell proliferation when oxygen becomes scarce. Forms heterodimers with other bHLH proteins. Interacts with TACC3. Three isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor; Transcription factor Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; aryl hydrocarbon receptor binding; sequence-specific DNA binding; protein heterodimerization activity; transcription coactivator activity; aryl hydrocarbon receptor activity; transcription factor binding; transcription factor activity Biological Process: embryonic placenta development; transcription, DNA-dependent; positive regulation of erythrocyte differentiation; positive regulation of transcription, DNA-dependent; cellular response to stress; mRNA transcription from RNA polymerase II promoter; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of protein sumoylation; positive regulation of hormone biosynthetic process; positive regulation of glycolysis; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; cell differentiation; regulation of transcription from RNA polymerase II promoter in response to oxidative stress Reference #:  P27540 (UniProtKB) Alt. Names/Synonyms: ARNT; ARNT protein; Aryl hydrocarbon receptor nuclear translocator; BHLHE2; Class E basic helix-loop-helix protein 2; Dioxin receptor, nuclear translocator; HIF-1-beta; HIF-1beta; HIF1-beta; HIF1B; HIF1BETA; hypoxia-inducible factor 1, beta subunit; Hypoxia-inducible factor 1-beta; TANGO Gene Symbols: ARNT Molecular weight: 86,636 Da Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states CST Pathways:  Angiogenesis  |  mTOR Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ARNT 1D7G - C=87-145 (human) 1X0O - A=354-470 (human) 2A24 - B=358-465 (human) 2ARN - A=335-462 (human) 2B02 - A=354-470 (human) 2HV1 - A/B=354-470 (human) 2K7S - A=356-470 (human) 3F1N - B=356-470 (human) 3F1O - B=356-470 (human) 3F1P - B=356-470 (human) 3H7W - B=356-470 (human) 3H82 - B=356-470 (human) 4EQ1 - A/B=357-464 (human) 4GHI - A=239-350 (human) 4GS9 - A=239-350 (human) 4H6J - B=357-470 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1D7G 1X0O 2A24 2ARN 2B02 2HV1 2K7S 3F1N 3F1O 3F1P 3H7W 3H82 4EQ1 4GHI 4GS9 4H6J  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
transcription, altered: S77‑p inhibition: S77‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T11-p	TTANPEMtSDVPSLG
0	2		K58-a	DDGEGNSkFLRCDDD
0	1		S68-p	RCDDDQMsNDKERFA
1	11		S77-p	DKERFARsDDEQSSA
1	0		K245	DLKTGTVKKEGQQSS
1	0		S348-p	GRLQVTSsPNCTDMS
0	9		S558-p	QDRDPRFsEIyHNIN
0	125		Y561-p	DPRFsEIyHNINADQ
0	1		T593-p	QGNTFPPtPRPAENF
0	13		T636-p	SNPTQGAtPtWtPTT
0	4		T638-p	PTQGAtPtWtPTTRS
0	5		T640-p	QGAtPtWtPTTRSGF
0	1		K659	VATQATAKTRTSQFG
0	1		S669-p	TSQFGVGsFQTPSSF
0	1		S788-p	LTMFPPFsE______

	mouse
T11	TTANPEMTSDVPSLG
K58	DEVEVNTKFLRCDDD
C68	RCDDDQMCNDKERFA
S77-p	DKERFARsDDEQSSA
K245-s	DLKTGTVkKEGQQSS
S348	GRLQVTSSPNCTDMS
P560	QDRDPRFPEIYPSIT
Y563	DPRFPEIYPSITADQ
N595	QGSSFPPNPRPAENF
A638	SNPAQGSAPTWTSSS
T640	PAQGSAPTWTSSSRP
T642	QGSAPTWTSSSRPGF
K661-u	VPTQATAkTRSSQFG
N671	SSQFGVNNFQTSSSF
S790	LTMFPPFSE______

	rat
T11	TTANPEMTSDVPSLG
K58	DEGEVNSKFLRCDDE
C68	RCDDEQMCNDKERFA
S77-p	DKERFARsDDEQSSA
K245	DLKTGTVKKEGQQSS
S348	GRLQVTSSPNCTDMS
S570	QDRDPRFSEIYPNIS
Y573	DPRFSEIYPNISADQ
N605	QGSSFPPNPRPAENF
A648	SNLTQGSAPTWTSST
T650	LTQGSAPTWTSSTRP
T652	QGSAPTWTSSTRPGF
K670	LPTQATAKTRSSQFG
N680	SSQFGVNNFQTSSSF
S799	LTMFPPFSE______

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