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Protein Page:
PIGV (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PIGV Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly. Defects in PIGV are the cause of hyperphosphatasia with mental retardation type 1 (HPMRS1). It is a syndrome characterized by elevated serum alkaline phosphatase, severe mental retardation, seizures, hypotonia, facial dysmorphism, and hypoplastic terminal phalanges. Belongs to the PIGV family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Transferase; Endoplasmic reticulum; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, integral; EC 2.4.1.-
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: mannosyltransferase activity
Biological Process: cellular protein metabolic process; preassembly of GPI anchor in ER membrane; GPI anchor biosynthetic process; C-terminal protein lipidation; post-translational protein modification
Reference #:  Q9NUD9 (UniProtKB)
Alt. Names/Synonyms: FLJ20477; GPI mannosyltransferase 2; GPI mannosyltransferase II; GPI-MT-II; phosphatidylinositol glycan anchor biosynthesis, class V; phosphatidylinositol glycan, class V; Phosphatidylinositol-glycan biosynthesis class V protein; PIG-V; PIGV
Gene Symbols: PIGV
Molecular weight: 55,713 Da
Basal Isoelectric point: 8.2  Predict pI for various phosphorylation states
Select Structure to View Below

PIGV

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K283-ub LVQLAVDkGYRIAEG
0 2 S443-p WKPLAEDsPPGQKVP
  mouse

 
K283 LLQLAADKGYRLAGE
S443 GKLPQEKSPPGQKAP
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