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Protein Page:
PIGV (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

PIGV Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly. Defects in PIGV are the cause of hyperphosphatasia with mental retardation type 1 (HPMRS1). It is a syndrome characterized by elevated serum alkaline phosphatase, severe mental retardation, seizures, hypotonia, facial dysmorphism, and hypoplastic terminal phalanges. Belongs to the PIGV family. Note: This description may include information from UniProtKB.
Protein type: EC 2.4.1.-; Endoplasmic reticulum; Membrane protein, integral; Transferase; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component: endoplasmic reticulum membrane; integral to membrane; mannosyltransferase complex
Molecular Function: mannosyltransferase activity; dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity
Biological Process: cellular protein metabolic process; preassembly of GPI anchor in ER membrane; GPI anchor biosynthetic process; C-terminal protein lipidation; post-translational protein modification
Disease: Hyperphosphatasia With Mental Retardation Syndrome 1
Reference #:  Q9NUD9 (UniProtKB)
Alt. Names/Synonyms: FLJ20477; GPI mannosyltransferase 2; GPI mannosyltransferase II; GPI-MT-II; phosphatidylinositol glycan anchor biosynthesis, class V; phosphatidylinositol glycan, class V; Phosphatidylinositol-glycan biosynthesis class V protein; PIG-V; PIGV
Gene Symbols: PIGV
Molecular weight: 55,713 Da
Basal Isoelectric point: 8.2  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.



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