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PLA2G2E (human)

Overview PLA2G2E PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids. Belongs to the phospholipase A2 family. Note: This description may include information from UniProtKB. Protein type: Lipid Metabolism - arachidonic acid; Secreted; Lipid Metabolism - ether lipid; EC 3.1.1.4; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase; Secreted, signal peptide Cellular Component: extracellular region Molecular Function: phospholipase A2 activity; calcium ion binding Biological Process: phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; inflammatory response; lipid catabolic process Reference #:  Q9NZK7 (UniProtKB) Alt. Names/Synonyms: GIIE sPLA2; Group IIE secretory phospholipase A2; PA2GE; Phosphatidylcholine 2-acylhydrolase 2E; phospholipase A2, group IIE; PLA2G2E; sPLA2-IIE Gene Symbols: PLA2G2E Molecular weight: 15,989 Da Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states

Select Structure to View Below PLA2G2E

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y127-p	LGTYNRKyAHyPNKL
0	1		Y130-p	YNRKyAHyPNKLCtG
0	1		T136-p	HyPNKLCtGPtPPC_
0	1		T139-p	NKLCtGPtPPC____

	mouse
Y127	LNTYNRKYAHYPNKL
Y130	YNRKYAHYPNKLCTG
T136	HYPNKLCTGPTPPC_
T139	NKLCTGPTPPC____

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