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ACER3 (human)

Overview ACER3 Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity. Belongs to the alkaline ceramidase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Lipid Metabolism - sphingolipid; Membrane protein, integral; Hydrolase; EC 3.5.1.- Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; integral to Golgi membrane Biological Process: sphingolipid metabolic process; sphingolipid biosynthetic process; phospholipid metabolic process; positive regulation of cell proliferation; sphingosine biosynthetic process; ceramide metabolic process Reference #:  Q9NUN7 (UniProtKB) Alt. Names/Synonyms: ACER3; Alkaline CDase 3; Alkaline ceramidase 3; Alkaline dihydroceramidase SB89; Alkaline phytoceramidase; AlkCDase 3; APHC; FLJ11238; PHCA; phytoceramidase, alkaline Gene Symbols: ACER3 Molecular weight: 31,552 Da Basal Isoelectric point: 8.87  Predict pI for various phosphorylation states

Select Structure to View Below ACER3

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T124-p	VNYHLLFtLVLFSLI
0	1		T133-p	VLFSLIVtTVYLKVK

	mouse
T124	INYHLLFTLFLYSLT
T133	FLYSLTVTTIYLKVK

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