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Protein Page:
GZMA (human)

Overview
GZMA This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Involved in apoptosis. Homodimer; disulfide-linked. Interacts with APEX1. Dexamethasone (DEX) induces expression of isoform beta and represses expression of isoform alpha. The alteration in expression is mediated by binding of glucocorticoid receptor to independent promoters adjacent to the alternative first exons of isoform alpha and isoform beta. Belongs to the peptidase S1 family. Granzyme subfamily. 2 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Protease; EC 3.4.21.78; Secreted, signal peptide; Secreted
Cellular Component: extracellular region; immunological synapse; nucleus
Molecular Function: protein binding; protein homodimerization activity; serine-type endopeptidase activity
Biological Process: proteolysis involved in cellular protein catabolic process; apoptosis; positive regulation of apoptosis; cytolysis; negative regulation of oxidoreductase activity; negative regulation of endodeoxyribonuclease activity; immune response; negative regulation of DNA binding
Reference #:  P12544 (UniProtKB)
Alt. Names/Synonyms: CTL tryptase; CTLA3; Cytotoxic T-lymphocyte proteinase 1; Fragmentin-1; GRAA; Granzyme A; Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3); Granzyme-1; GZMA; H factor; Hanukah factor serine protease); Hanukkah factor; HF; HFSP
Gene Symbols: GZMA
Molecular weight: 28,999 Da
Basal Isoelectric point: 9.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GZMA

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T257-p HLNWIIMtIKGAV__
  mouse

 
I255 HLNWIKKIMKGSV__
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