|
GPX4
Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. Belongs to the glutathione peroxidase family. 2 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
|
| Protein type: Mitochondrial; Lipid Metabolism - arachidonic acid; Oxidoreductase; Other Amino Acids Metabolism - glutathione; EC 1.11.1.12; Nuclear envelope |
|
Cellular Component: mitochondrion
|
|
Molecular Function: phospholipid-hydroperoxide glutathione peroxidase activity; glutathione peroxidase activity
|
|
Biological Process: multicellular organismal development; phospholipid metabolic process; response to oxidative stress
|
|
Reference #:
P36969 (UniProtKB)
|
| Alt. Names/Synonyms: Glutathione peroxidase 4; glutathione peroxidase 4 (phospholipid hydroperoxidase); GPx-4; GPX4; GSHPx-4; MCSP; PHGPx; phospholipid hydroperoxidase; Phospholipid hydroperoxide glutathione peroxidase, mitochondrial; snGPx; snPHGPx; sperm nucleus glutathione peroxidase |
| Gene Symbols: GPX4 |
|
Molecular weight: 22,175 Da
|
|
Basal Isoelectric point: 8.69
Predict pI for various phosphorylation states
|
