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Protein Page:
CYP4F22 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CYP4F22 Defects in CYP4F22 are the cause of ichthyosis lamellar type 3 (LI3). LI is a non-bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. It is one the most severe forms of ichthyoses apparent at birth and persisting throughout life. LI patients are born encased in a tight, shiny, translucent covering called collodion membrane. Over the first weeks of life, the collodion membrane is gradually replaced by generalized large, dark brown, plate-like scales with minimal to no erythroderma. Tautness of facial skin commonly results in ectropion, eclabium and scarring alopecia of the scalp. Common complications are severe heat intolerance and recurrent ear infections. Belongs to the cytochrome P450 family. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; EC 1.14.14.-
Chromosomal Location of Human Ortholog: 19p13.12
Cellular Component: endoplasmic reticulum membrane
Molecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; iron ion binding; heme binding; monooxygenase activity
Reference #:  Q6NT55 (UniProtKB)
Alt. Names/Synonyms: CP4FN; CYP4F22; Cytochrome P450 4F22; cytochrome P450, family 2, subfamily E, polypeptide 2 homolog; cytochrome P450, family 4, subfamily F, polypeptide 22; FLJ39501; LI3
Gene Symbols: CYP4F22
Molecular weight: 61,958 Da
Basal Isoelectric point: 8.95  Predict pI for various phosphorylation states
Select Structure to View Below

CYP4F22

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K296-ub QGAEAWLkAKQGKTL
0 1 Y465-p QQRSPLAyVPFsAGP
0 1 S469-p PLAyVPFsAGPRNCI
  mouse

 
K297 QGAEAWLKAKQGKTL
F466 QQRSPLAFVPFSAGP
S470 PLAFVPFSAGPRNCI
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