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PLA2G2D (human)

Overview PLA2G2D PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2- linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined. Belongs to the phospholipase A2 family. Note: This description may include information from UniProtKB. Protein type: Secreted; Lipid Metabolism - linoleic acid; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - ether lipid; Phospholipase; Lipid Metabolism - arachidonic acid; Lipid Metabolism - glycerophospholipid; Secreted, signal peptide; EC 3.1.1.4 Cellular Component: extracellular region Molecular Function: phospholipase A2 activity; calcium ion binding Biological Process: phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; inflammatory response; lipid catabolic process Reference #:  Q9UNK4 (UniProtKB) Alt. Names/Synonyms: GIID sPLA2; Group IID secretory phospholipase A2; PA2GD; Phosphatidylcholine 2-acylhydrolase 2D; phospholipase A2, group IID; PLA2G2D; PLA2IID; secretory phospholipase A2s; Secretory-type PLA, stroma-associated homolog; sPLA2-IID; sPLA2S; SPLASH Gene Symbols: PLA2G2D Molecular weight: 16,546 Da Basal Isoelectric point: 8.6  Predict pI for various phosphorylation states

Select Structure to View Below PLA2G2D

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y82-p	KTQGCSIyKDyyRYN
0	1		Y85-p	GCSIyKDyyRYNFSQ
0	1		Y86-p	CSIyKDyyRYNFSQG
0	1		Y126-p	LKRNLDTyQKRLRFY

	mouse
-	under review
-	under review
-	under review
Y125	LKQNLDSYNKRLRYY

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